CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Benzylamine, N,N - dimethyl -

RTECS #: DP4500000

CAS #: 103-83-3

UPDATE: February 2008 MW: 135.23 MF: C9H13N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Araldite accelerator 062
  2. BDMA
  3. Benzenemethanamine, N,N - dimethyl - (9CI)
  4. Benzyl - N,N - dimethylamine
  5. Dimethylbenzylamine
  1. N,N - Dimethylbenzenemethanamine
  2. N,N - Dimethylbenzylamine
  3. N - (Phenylmethyl) dimethylamine
  4. N - Benzyldimethylamine
  5. Sumine 2015


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 mg severe DCTODJ 8,43,1985
skin
rabbit 		500 mg/4 hour severe DCTODJ 8,43,1985


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 1,200 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		TPKVAL 5,6,1963
inhalation
mouse 		lethal concentration : 1.8 gm/m3/2 hour N/R TPKVAL 5,6,1963
inhalation
rat 		lowest published lethal concentration: 1,200 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		TPKVAL 5,6,1963
inhalation
rat 		lethal concentration : 1.8 gm/m3/2 hour Gastrointestinal: Necrotic changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes 		TPKVAL 5,6,1963
ocular
rabbit 		lowest published toxic dose: 100 pph Eye: Lacrimation

Eye: Conjunctiva irritation 		TPKVAL 5,6,1963
oral
rat 		lethal dose (50 percent kill): 265 mg/kg N/R KorCJ# 22AUG1974
skin
mouse 		lowest published toxic dose: 100 pph Skin: After topical application: Corrosive TPKVAL 5,6,1963
skin
rabbit 		lethal dose (50 percent kill): 1,660 mg/kg Behavioral: Tremor

Behavioral: Excitement 		DCTODJ 8,43,1985
skin
rabbit 		lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 5,6,1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 0.15 gm/m3/91 day- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen 		TPKVAL 5,6,1963
inhalation
rat 		lowest published toxic concentration: 0.35 gm/m3/90 day- intermittent Lung, Thorax, or Respiration: Respiratory depression TPKVAL 5,6,1963
inhalation
rat 		lowest published toxic concentration: 0.35 gm/m3/120 day- intermittent Lung, Thorax, or Respiration: Dyspnea TPKVAL 5,6,1963
inhalation
rat 		lowest published toxic concentration: 0.35 gm/m3/0.5 year- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		TPKVAL 5,6,1963
inhalation
rat 		lowest published toxic concentration: 0.35 gm/m3/122 day- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Other changes in urine composition 		TPKVAL 5,6,1963


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83034;
Number of Industries 5;
Total Number of Facilities 142;
Number of Occupations 34;
Total Number of Employees Exposed 23,940
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83034;
Number of Industries 8;
Total Number of Facilities 110;
Number of Occupations 8;
Total Number of Employees Exposed 2,150;
Total Number of Female Employees Exposed 249


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as catalyst for EPOXY and POLYURETHANE resin systems
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
KorCJ# Personal Communication from C.J. Korpics, Sherwin-Williams Chemicals, 1310 Expressway Drive, Toledo, OH 43608, Aug. 22, 1974
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as catalyst for EPOXY and POLYURETHANE resin systems

RTECS Compound Description:
   Primary Irritant

 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us