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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzyl alcohol

RTECS #

DN3150000

CAS #

100-51-6

Updated

July 2012

Molecular Weight

108.15

Molecular Formula

C7H8O

Synonyms

alpha-Hydroxytoluene
alpha-Toluenol
Benzal alcohol
Benzenecarbinol
Benzenemethanol
Benzoyl alcohol
Hydroxytoluene
Methanol, phenyl-
NCI-C06111
Phenolcarbinol
Phenylcarbinol
Phenylmethanol
Phenylmethyl alcohol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 1%/2DCODEDG 61,217,2009
skin /man 16 mg/48H mildCTOIDG 94(8),41,1979
skin /pig 100% moderateFCTXAV 11,1011,1973
skin /rabbit 100 mg/24H moderateCTOIDG 94(8),41,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster4 µg/LNTPTR* NTP-TR-343,1989
DNA Damageliver/rat10 mmol/LEMMUEG 24,181,1994
DNA Damageliver/human0.1 mmol/l/48HMUREAV 696,21,2010
DNA Damagelymphocyte/human25 mmol/LFCTOD7 48,1239,2010
DNA repair/Bacillus subtilis21 mg/discOIGZDE 34,267,1985
mutation in microorganismslymphocyte/mouse250 mg/L (+enzymatic activation step)NTPTR* NTP-TR-343,1989
other mutation test systemsoral/Drosophila melanogaster50 mmol/LFCTOD7 46,1034,2008

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 6 gm/kg (6-13D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TCMUD8 7,29,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): >500 mg/m3Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,132,1984
inhalation/rat lethal concentration (50 percent kill): >500 mg/m3Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,132,1984
inhalation/rat lowest published toxic concentration: 46 mg/m3Brain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning
VCVGK* -,132,1984
inhalation/rat Lowest published lethal concentration: 1000 ppm/8HAMIHBC 4,119,1951
intraarterial/rat lethal dose (50 percent kill): 441 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Dyspnea
TXAPA9 18,60,1971
intraperitoneal/mouse lethal dose (50 percent kill): 650 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
JPMSAE 75,702,1986
intraperitoneal/rat lethal dose (50 percent kill): 400 mg/kgNPIRI* 1,6,1974
intraperitoneal/rat lowest published toxic dose: 514 mg/kgBehavioral: AtaxiaVCVGK* -,132,1984
intraperitoneal/rat lowest published lethal dose: 650 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,132,1984
intravenous/cat lowest published lethal dose: 625 mg/kgJPETAB 16,1,1920
intravenous/Dog lowest published lethal dose: 50 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 18,60,1971
intravenous/mouse lethal dose (50 percent kill): 324 mg/kgAIPTAK 135,330,1962
intravenous/rat lethal dose (50 percent kill): 53 mg/kgLung, Thorax, or Respiration: DyspneaTXAPA9 18,60,1971
oral/guinea pig lethal dose (50 percent kill): 2500 mg/kgGISAAA 50(7),81,1985
oral/guinea pig lethal dose (50 percent kill): 2500 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,132,1984
oral/mouse lethal dose (50 percent kill): 1360 mg/kgGISAAA 50(7),81,1985
oral/mouse lethal dose (50 percent kill): 1360 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,132,1984
oral/rabbit lethal dose (50 percent kill): 1040 mg/kgBehavioral: Somnolence (general depressed activity)JPETAB 84,358,1945
oral/rabbit lethal dose (50 percent kill): 1040 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,132,1984
oral/rat lethal dose (50 percent kill): 1660 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,132,1984
oral/rat lethal dose (50 percent kill): 1230 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Coma
FCTXAV 2,327,1964
oral/rat lethal dose (50 percent kill): 1.5 mL/kgTPKVAL 11,135,1969
oral/wild bird lethal dose (50 percent kill): 100 mg/kgTXAPA9 21,315,1972
parenteral/Dog lowest published lethal dose: 9 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Other changes
TXAPA9 25,153,1973
skin/cat lowest published lethal dose: 10 gm/kgBehavioral: Tremor

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands
JPETAB 84,358,1945
skin/rabbit lethal dose (50 percent kill): 2000 mg/kgVCVGK* -,132,1984
subcutaneous/rat lowest published lethal dose: 1700 mg/kgEye: Miosis (pupilliary constriction)

Behavioral: Coma

Kidney, Ureter, and Bladder: Other changes
RMSRA6 15,561,1895

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 10 pph/45D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Headache

Gastrointestinal: Nausea or vomiting
VCVGK* -,132,1994
inhalation/mammal (species unspecified) lowest published toxic concentration: 42 mg/m3/122D- intermittentCardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,132,1994
oral/mouse lowest published toxic dose: 10000 mg/kg/16D- intermittentBehavioral: Somnolence (general depressed activity)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/mouse lowest published toxic dose: 52000 mg/kg/13W- intermittentBehavioral: Change in motor activity (specific assay)HPV141 -,-,2001
oral/mouse lowest published toxic dose: 6000 mg/kg/8D- intermittentBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/mouse lowest published toxic dose: 12 gm/kg/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-343,1989
oral/rat lowest published toxic dose: 2100 mg/kg/21D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 50(7),81,1985
oral/rat lowest published toxic dose: 13 gm/kg/13W- intermittentBrain and Coverings: Other degenerative changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-343,1989
oral/rat lowest published toxic dose: 24 mL/kg/12D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
CBPCEE 99,445,1991
oral/rat lowest published toxic dose: 103000 mg/kg/103W- continuousEndocrine: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB90-110206
oral/rat lowest published toxic dose: 25200 mg/kg/6W- intermittentNutritional and Gross Metabolic: Changes in: Metabolic acidosisTOXID9 44,55,2005
oral/rat lowest published toxic dose: 52000 mg/kg/13W- intermittentBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/rat lowest published toxic dose: 206000 mg/kg/103W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV141 -,-,2001
oral/rat lowest published toxic dose: 10000 mg/kg/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV141 -,-,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWENTOX* -,262,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWHUTOX* -,259,1996
TOXICOLOGY REVIEWHUTOX* -,623,1996
TOXICOLOGY REVIEWDERCL* 27,289,2009
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWREPTED 32,142,2011
TOXICOLOGY REVIEWMUREAV 653,99,2008
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,297,1998
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (45 mg/m3), NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 11360; Number of Industries 128; Total Number of Facilities 19005; Number of Occupations 127; Total Number of Employees Exposed 404916; Total Number of Female Employees Exposed 236470
National Occupational Hazard Survey 1974Hazard Code 11360; Number of Industries 85; Total Number of Facilities 7284; Number of Occupations 68; Total Number of Employees Exposed 138757

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);no evidence:mouse;rat
NTP Carcinogenesis Studies (gavage);no evidence:mouse,rat NTPTR* NTP-TR-343,1989
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