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Benzoyl peroxide

RTECS #: DM8575000

CAS #: 94-36-0


UPDATE: May 2009 MW: 242.24 MF: C14H10O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Acnegel
  2. Aztec BPO
  3. BZF - 60
  4. Benzoperoxide
  5. Benzoylperoxid (German)
  6. Benzoyl peroxide (ACGIH:OSHA)
  7. Benzoylperoxyde (Dutch)
  8. Benzoyl superoxide
  9. Cadat BPO
  10. Cadox B - CH 50
  11. Cadox BS
  12. Debroxide
  13. Dibenzoylperoxid (German)
  14. Dibenzoyl peroxide
  15. Dibenzoylperoxyde (Dutch)
  16. Diphenylglyoxal peroxide
  17. Fostex
  18. Garox
  19. Incidol
  20. Loroxide
  1. Lucidol
  2. Luperco AA
  3. Luperco AST
  4. Luperox FL
  5. Nayper B and BO
  6. Norox bzp - 250
  7. Norox bzp - C - 35
  8. Novadelox
  9. Oxylite
  10. Panoxyl
  11. Perossido di benzoile (Italian)
  12. Peroxide, dibenzoyl
  13. Peroxyde de benzoyle (French)
  14. Persadox
  15. Quinolor compound
  16. Superox 744
  17. Theraderm
  18. Topex
  19. Vanoxide
  20. Xerac


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 85JCAE -,324,1986
skin
human
5%/48 hour ADVEA4 34,68,1996
skin
human
5% VCVGK* -,543,1994
skin
human
5%/8 week- intermittent severe ADVEA4 62,458,1982


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human other cell types 100 µmol/L CNREA8 45,2522,1985
DNA damage mouse other cell types 1 µmol/L PAACA3 24,108,1983
DNA damage skin
mouse
242 mg/kg/4 week- intermittent CRNGDP 25,431,2004
DNA inhibition human other cell types 56 µmol/L CNREA8 45,2522,1985
DNA repair Escherichia coli 250 µg/well MUREAV 133,161,1984
unscheduled DNA synthesis rat liver 100 pmol/L CRNGDP 5,1547,1984
mutation in mammalian somatic cells human kidney 300 µmol/L CRNGDP 13,1783,1992
morphological transform mouse fibroblast 0.1 µmol/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
other mutation test systems human other cell types 56 µmol/L CNREA8 45,2522,1985
specific locus test mouse fibroblast 25 µmol/L/5 week MUREAV 577S,1,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 24 gm/kg/30 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
SCIEAS 213,1023,1981
skin
mouse
lowest published toxic dose: 64,000 mg/kg/40 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens
CRNGDP 21,811,2000
skin
mouse
lowest published toxic dose: 28,800 mg/kg/18 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens
ARTODN 78,139,2004


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 147 mg/kg N/R VCVGK* -,542,1994
intraperitoneal
rat
lethal dose (50 percent kill): 372.8 mg/kg N/R VCVGK* -,543,1994
oral
mouse
lethal dose (50 percent kill): 1,200 mg/kg N/R VCVGK* -,542,1994
oral
rat
lethal dose (50 percent kill): 7,710 mg/kg Lung, Thorax, or Respiration: Cyanosis

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition
ARCOC* JUN1982
oral
rat
lethal dose (50 percent kill): 6,400 mg/kg N/R VCVGK* -,542,1994
skin
mammal (species unspecified)
lethal dose (50 percent kill): >1 gm/kg N/R KODAK* #900713


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 121,120 µg/kg/4 week- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation CRNGDP 25,431,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,345,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 36,267,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 36,267,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,345,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,345,1999
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
BPCEM* 17,237,2003
TOXICOLOGY REVIEW
MUREAV 533,153,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 DTLVS* 3,23,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 5 mg/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg/m3, short term exposure limit 5 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3,KZG- week 5 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BENZOYL PEROXIDE-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 11280;
Number of Industries 47;
Total Number of Facilities 5,255;
Number of Occupations 42;
Total Number of Employees Exposed 32,909
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 11280;
Number of Industries 62;
Total Number of Facilities 7,331;
Number of Occupations 75;
Total Number of Employees Exposed 87,420;
Total Number of Female Employees Exposed 11,192


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as polymerization initiator, curing agent and cross-linking agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Benzoyl peroxide, 5009


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ADVEA4 Acta Dermato-Venereologica. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.1- 1920-
ARCOC* ARCO Chemical Company Report. (3801 West Chester Pike, Newton Square, PA 19073)
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BPCEM* Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as polymerization initiator, curing agent and cross-linking agent

NIOSH PROFILE (PEROXIDES, ORGANIC), SRC, 12/79

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), SRI, 2/77

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), FIRL, 4/78

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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