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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzoyl chloride

RTECS #

DM6600000

CAS #

98-88-4

Updated

September 201

Molecular Weight

140.57

Molecular Formula

C7H5ClO

Synonyms

alpha-Chlorobenzaldehyde
Benzaldehyde, alpha-chloro-
Benzenecarbonyl chloride
Benzoic acid, chloride
Benzoyl chloride (ACGIH)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 0.1 mL severeHPV140 -,-,2003
skin /rabbit 0.5 mLHPV140 -,-,2003

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium1 µmol/plate (+enzymatic activation step)MUREAV 58,11,1978
mutation in microorganisms/Salmonella typhimurium5 mg/plate (-enzymatic activation step)TSCAT* FYI-OTS-1180-0107
mutation in microorganisms/Saccharomyes cerevisiae304 mg/L/16HMUTAEX 20,105,2004

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 9200 mg/kg/50W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
GANNA2 72,655,1981
skin/mouse toxic dose: 17600 mg/kg/42W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
GANNA2 72,655,1981
skin/mouse toxic dose: 35200 mg/kg/42W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GANNA2 72,655,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 2 ppm/1MOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes
TGNCDL 2,31,1961
inhalation/rat lethal concentration (50 percent kill): 1870 mg/m3/2H85GMAT -,25,1982
inhalation/rat lethal concentration (50 percent kill): 1450 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Dyspnea
HPV140 -,-,2003
inhalation/rat Lowest published lethal concentration: 1453 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Dyspnea
HPV140 -,-,2003
oral/rat lethal dose (50 percent kill): 2528 mg/kgBehavioral: Somnolence (general depressed activity)HPV140 -,-,2003
oral/rat lethal dose (50 percent kill): 1900 mg/kgHPV140 -,-,2003
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgSkin: After topical application: Primary irritationHPV140 -,-,2003
skin/rabbit lethal dose (50 percent kill): 790 mg/kgHPV140 -,-,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.5 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 71,453,1999
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 29,83,1982
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 71,453,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 29,83,1982
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 ppm (2.8 mg/m3);KZW 0.5 ppm (2.8 mg/m3), 2007
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.5 ppm (2.8 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 0.5 ppm (2.8 mg/m3), MAY2011
Occupational Exposure Limit-HUNGARYtime-weighted average 2.8 mg/m3, SEP2000
Occupational Exposure Limit-PERUshort term exposure limit 0.5 ppm (2.9 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81724; Number of Industries 5; Total Number of Facilities 148; Number of Occupations 30; Total Number of Employees Exposed 6871; Total Number of Female Employees Exposed 2826
National Occupational Hazard Survey 1974Hazard Code 81724; Number of Industries 5; Total Number of Facilities 117; Number of Occupations 6; Total Number of Employees Exposed 1008

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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