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Registry of Toxic Effects of Chemical Substances (RTECS)

1H-Benzotriazole

RTECS #

DM1225000

CAS #

95-14-7; 25377-81-5; 27556-51-0

Updated

November 2009

Molecular Weight

119.14

Molecular Formula

C6H5N3

Synonyms

1,2,3-Benzotriazole
1,2,3-Triazaindene
1,2,-Aminozophenylene
2,3-Diazaindole
Azimidobenzene
Aziminobenzene
Benzene azimide
Benzisotriazole
Benztriazole
Cobratec #99
NCI-C03521
NSC-3058
U-6233

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeHPV139 -,-,2001

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformembryo/rat94 µg/plateJJATDK 1,190,1981
mutation in microorganisms/Salmonella typhimurium100 µg/plate (-enzymatic activation step)IAPUDO 27,283,1980
mutation in microorganisms/Escherichia coli33300 ng/plate (+enzymatic activation step)ENMUDM 7(Suppl 5),1,1985

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 770 gm/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma
NCITR* NCI-TR-88,1978
oral/rat lowest published toxic dose: 220 gm/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Brain and Coverings: Tumors
NCITR* NCI-TR-88,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 1910 mg/m3/3HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0520637
inhalation/rat lethal concentration (50 percent kill): >1500 mg/m3/4HLung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV139 -,-,2001
inhalation/rat lethal concentration (50 percent kill): 1910 mg/m3/3HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Hemorrhage
HPV139 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 400 mg/kgFATOAO 41,708,1978
intravenous/mouse lethal dose (50 percent kill): 238 mg/kgHPV139 -,-,2001
oral/guinea pig lethal dose (50 percent kill): 500 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis
GISAAA 46(11),70,1981
oral/mouse lethal dose (50 percent kill): 615 mg/kgNTIS** AD-A067-313
oral/rat lethal dose (50 percent kill): 560 mg/kgHPV139 -,-,2001
skin/rabbit lowest published lethal dose: 450 mg/kgNTIS** OTS0520182
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgHPV139 -,-,2001
skin/rat lethal dose (50 percent kill): >1 gm/kgNTIS** OTS0516745
skin/rat lethal dose (50 percent kill): >2000 mg/kgLung, Thorax, or Respiration: DyspneaHPV139 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 109 mg/kg/26W- intermittentEndocrine: Other changes

Blood: Normocytic anemia

Blood: Luekopenia
GISAAA 46(11),70,1981

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 589,208,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82113; Number of Industries 144; Total Number of Facilities 17143; Number of Occupations 107; Total Number of Employees Exposed 279549; Total Number of Female Employees Exposed 40869
National Occupational Hazard Survey 1974Hazard Code 82113; Number of Industries 23; Total Number of Facilities 1661; Number of Occupations 33; Total Number of Employees Exposed 5550

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse,ratNCITR* NCI-TR-88,1978
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