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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Benzothiazolethiol

RTECS #

DL6475000

CAS #

149-30-4

Updated

April 2013

Molecular Weight

167.25

Molecular Formula

C7H5NS2

Synonyms

2(3H)-Benzothiazolethione
2-Benzothiazolyl mercaptan
2-Mercaptobenzothiazole
2-Merkaptobenzotiazol (Polish)
2-Merkaptobenzthiazol (Czech)
Benzothiazole-2-thione
Captax
Dermacid
Kaptax (Czech)
MBT
Mercaptobenzothiazole
Mertax
NCI-C56519
Pennac MBT powder
Rokon
Rotax
Sulfadene
Thiotax
USAF GY-3
USAF XR-29
Vulkacit mercapto

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /mouse 7.5%/12DNTPTR* NTP-IMM-90003

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster373500 µg/L (+enzymatic activation step)HPV138 -,-,2001
morphological transformfibroblast/mouse0.001 mg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001
sister chromatid exchangeovary/hamster351 mg/LNTPTR* NTP-TR-332,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 20227 mg/kg (multigeneration)Reproductive: Other effects on male

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HPV138 -,-,2001
oral/rabbit 7800 mg/kg (6-18D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
HPV138 -,-,2001
parenteral/rat 800 mg/kg (2D male/2D prior to copulation)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
BEXBAN 93,107,1982
parenteral/rat 400 mg/kg (4-11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
BEXBAN 93,107,1982
subcutaneous/mouse 4176 mg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Gastrointestinal system
NTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse toxic dose: 195 gm/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-332,1988
oral/mouse lowest published toxic dose: 35 gm/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Tumors
NTIS** PB223-159
oral/mouse lowest published toxic dose: 193125 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NTIS** PB88-245154/AS
oral/mouse lowest published toxic dose: 273750 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV138 -,-,2001
oral/rat lowest published toxic dose: 195 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Gastrointestinal: Tumors
NTPTR* NTP-TR-332,1988
oral/rat lowest published toxic dose: 386250 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Adrenal cortex tumors

Reproductive: Other reproductive system tumors
NTIS** PB88-245154/AS
oral/rat lowest published toxic dose: 273750 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV138 -,-,2001
oral/rat lowest published toxic dose: 193125 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB88-245154/AS
oral/rat lowest published toxic dose: 193125 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB88-245154/AS
oral/rat lowest published toxic dose: 193125 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Brain and Coverings: Tumors

Endocrine: Adrenal cortex tumors
NTIS** PB88-245154/AS
subcutaneous/mouse lowest published toxic dose: 215 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >1270 mg/m3EPASR* 8EHQ-1190-0987S
inhalation/rat lethal concentration (50 percent kill): >1270 mg/m3/4HHPV138 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 100 mg/kgNTIS** AD277-689
intraperitoneal/rat lethal dose (50 percent kill): 300 mg/kgMEPAAX 16,35,1965
oral/mouse lethal dose (50 percent kill): 1158 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
SRTCAC 36(1-4),10,1989
oral/mouse lethal dose (50 percent kill): 2000 mg/kgHPV138 -,-,2001
oral/quail lethal dose (50 percent kill): >2150 mg/kgNTIS** OTS0535428
oral/rabbit lowest published lethal dose: 7500 mg/kgHPV138 -,-,2001
oral/rat lethal dose (50 percent kill): 100 mg/kgIPSTB3 3,93,1976
skin/rabbit lethal dose (50 percent kill): >7940 mg/kgBehavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay)
ATDAEI 1,62,1990
skin/rabbit lethal dose (50 percent kill): >7940 mg/kgHPV138 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 770 mg/kg/7D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Liver function tests impaired
TXAPA9 14,221,1969
intraperitoneal/mouse lowest published toxic dose: 770 mg/kg/7D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
HPV138 -,-,2001
oral/mouse lowest published toxic dose: 18 gm/kg/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-332,1988
oral/mouse lowest published toxic dose: 97500 mg/kg/13W- intermittentLiver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-332,1988
oral/mouse lowest published toxic dose: 174 gm/kg/86W- continuousKidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ESKHA5 (107),44,1989
oral/mouse lowest published toxic dose: 48750 mg/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV138 -,-,2001
oral/mouse lowest published toxic dose: 32424 mg/kg/80W- intermittentKidney, Ureter, and Bladder: Other changesHPV138 -,-,2001
oral/rat lowest published toxic dose: 12220 mg/kg/13W- intermittentLiver: Changes in liver weightNTPTR* NTP-TR-332,1988
oral/rat lowest published toxic dose: 29988 mg/kg/4W- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV138 -,-,2001
oral/rat lowest published toxic dose: 68250 mg/kg/13W- intermittentLiver: Changes in liver weight

Endocrine: Differential effect of sex or castration on observed toxicity

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV138 -,-,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJJOMDZ 15,808,1973
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,189,1998
Occupational Exposure Limit-GERMANYMAK 4 mg/m3, inhal, 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 4 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84030; Number of Industries 74; Total Number of Facilities 4825; Number of Occupations 62; Total Number of Employees Exposed 86509; Total Number of Female Employees Exposed 16409
National Occupational Hazard Survey 1974Hazard Code 84030; Number of Industries 45; Total Number of Facilities 2428; Number of Occupations 40; Total Number of Employees Exposed 42637

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse,rat
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-332,1988
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