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2 - Benzothiazolethiol

RTECS #: DL6475000

CAS #: 149-30-4


UPDATE: November 2007 MW: 167.25 MF: C7H5NS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2 (3H) - Benzothiazolethione
  2. 2 - Benzothiazolyl mercaptan
  3. 2 - Mercaptobenzothiazole
  4. 2 - Merkaptobenzotiazol (Polish)
  5. 2 - Merkaptobenzthiazol (Czech)
  6. Benzothiazole - 2 - thione
  7. Captax
  8. Dermacid
  9. Kaptax (Czech)
  10. MBT
  11. Mercaptobenzothiazole
  1. Mertax
  2. NCI - C56519
  3. Pennac MBT powder
  4. Rokon
  5. Rotax
  6. Sulfadene
  7. Thiotax
  8. USAF GY - 3
  9. USAF XR - 29
  10. Vulkacit mercapto


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
7.5%/12 day NTPTR* NTP-IMM-90003


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
sister chromatid exchange hamster ovary 351 mg/L NTPTR* NTP-TR-332,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
parenteral
rat
lowest published toxic dose: 800 mg/kg (2 day male/2 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
BEXBAN 93,107,1982
parenteral
rat
lowest published toxic dose: 400 mg/kg (4-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
BEXBAN 93,107,1982
subcutaneous
mouse
lowest published toxic dose: 4,176 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Gastrointestinal system
NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 35 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Tumors
NTIS** PB223-159
oral
mouse
toxic dose : 195 gm/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-332,1988
oral
mouse
lowest published toxic dose: 193,125 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NTIS** PB88-245154/AS
oral
rat
lowest published toxic dose: 195 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Gastrointestinal: Tumors
NTPTR* NTP-TR-332,1988
oral
rat
lowest published toxic dose: 193,125 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB88-245154/AS
oral
rat
lowest published toxic dose: 193,125 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB88-245154/AS
oral
rat
lowest published toxic dose: 193,125 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Brain and Coverings: Tumors

Endocrine: Adrenal cortex tumors
NTIS** PB88-245154/AS
oral
rat
lowest published toxic dose: 386,250 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Adrenal cortex tumors

Reproductive: Other reproductive system tumors
NTIS** PB88-245154/AS
subcutaneous
mouse
lowest published toxic dose: 215 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors
NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): >1,270 mg/m3 N/R EPASR* 8EHQ-1190-0987S
intraperitoneal
mouse
lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat
lethal dose (50 percent kill): 300 mg/kg N/R MEPAAX 16,35,1965
oral
mouse
lethal dose (50 percent kill): 1,158 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
SRTCAC 36(1-4),10,1989
oral
quail
lethal dose (50 percent kill): >2,150 mg/kg N/R NTIS** OTS0535428
oral
rat
lethal dose (50 percent kill): 100 mg/kg N/R IPSTB3 3,93,1976
skin
rabbit
lethal dose (50 percent kill): >7,940 mg/kg Behavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay)
ATDAEI 1,62,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 770 mg/kg/7 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Liver function tests impaired
TXAPA9 14,221,1969
oral
mouse
lowest published toxic dose: 18 gm/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-332,1988
oral
mouse
lowest published toxic dose: 97,500 mg/kg/13 week- intermittent Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-332,1988
oral
mouse
lowest published toxic dose: 174 gm/kg/86 week- continuous Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ESKHA5 (107),44,1989
oral
rat
lowest published toxic dose: 12,220 mg/kg/13 week- intermittent Liver: Changes in liver weight NTPTR* NTP-TR-332,1988
skin
human
lowest published toxic concentration: 1 pph/48 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,177,2002
skin
mouse
lowest published toxic dose: 5 pph/3 day- continuous Skin: After topical application: Dermatitis, allergic TOXID9 72,378,2003
skin
woman
lowest published toxic concentration: 1 pph/48 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,19,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
JJOMDZ 15,808,1973
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,189,1998
Occupational Exposure Limit - GERMANY MAK 4 mg/m3 (inhalable, skin, sen), 2005
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84030;
Number of Industries 45;
Total Number of Facilities 2,428;
Number of Occupations 40;
Total Number of Employees Exposed 42,637
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84030;
Number of Industries 74;
Total Number of Facilities 4,825;
Number of Occupations 62;
Total Number of Employees Exposed 86,509;
Total Number of Female Employees Exposed 16,409


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as vulcanization accelerator in rubber products
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-332,1988
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE

AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as vulcanization accelerator in rubber products

NIOSH PROFILE (MERCAPTOBENZOTHIAZOLES), SRC, 3/78

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

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