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Benzothiazole, 2,2' - dithiobis -

RTECS #: DL4550000

CAS #: 120-78-5


UPDATE: February 2006 MW: 332.48 MF: C14H8N2S4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2,2' - Dibenzothiazyl disulfide
  2. 2,2' - Dithiobis (benzothiazole)
  3. 2 - Benzothiazolyl disulfide
  4. 2 - Mercaptobenzothiazole disulfide
  5. 2 - Mercaptobenzothiazyl disulfide
  6. Altax
  7. Benzothiazole disulfide
  8. Benzothiazolyl disulfide
  9. Benzothiazyl disulfide
  10. Bis (2 - benzothiazyl) disulfide
  11. Bis (benzothiazolyl) disulfide
  12. Di - 2 - benzothiazolyl disulfide
  13. Dibenzothiazolyl disulphide
  1. Dibenzothiazyl disulfide
  2. Dibenzoylthiazyl disulfide
  3. Dibenzthiazyl disulfide
  4. Dwusiarczek dwubenzotiazylu (Polish)
  5. MBTS
  6. MBTS rubber accelerator
  7. Royal MBTS
  8. Thiofide
  9. USAF CY - 5
  10. USAF EK - 5432
  11. Vulkacit DM
  12. Vulkacit DM/mgc


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms mouse lymphocyte 15 mg/L (+enzymatic activation step) ENMUDM 5,193,1983
mutation in microorganisms Salmonella typhimurium 3,333 g/plate (+/-enzymatic activation step) EMMUEG 11(Suppl 12),1,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
parenteral
rat
lowest published toxic dose: 400 mg/kg (4-11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
BEXBAN 93,107,1982
parenteral
rat
lowest published toxic dose: 400 mg/kg (4-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death BEXBAN 93,107,1982
parenteral
rat
lowest published toxic dose: 800 mg/kg (2 day male/2 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
BEXBAN 93,107,1982
parenteral
rat
lowest published toxic dose: 800 mg/kg (2 day male/2 day prior to copulation) Reproductive: Effects on embryo or fetus: Fetal death BEXBAN 93,107,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 172 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat
lethal dose (50 percent kill): 2,600 mg/kg N/R IPSTB3 3,93,1976
intravenous
mouse
lethal dose (50 percent kill): 180 mg/kg N/R CSLNX* NX#02251
oral
mouse
lethal dose (50 percent kill): 7 gm/kg N/R IPSTB3 3,93,1976
oral
rat
lethal dose (50 percent kill): >12 gm/kg N/R NTIS** AD755-358
skin
rabbit
lethal dose (50 percent kill): >7,940 mg/kg N/R EPASR* 8EHQ-1190-0987S


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 9,100 mg/kg/13 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
KHZDAN 23,414,1980


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84830;
Number of Industries 12;
Total Number of Facilities 897;
Number of Occupations 28;
Total Number of Employees Exposed 11,180
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84830;
Number of Industries 19;
Total Number of Facilities 1,533;
Number of Occupations 42;
Total Number of Employees Exposed 50,590;
Total Number of Female Employees Exposed 11,091


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as vulcanization accelerator in rubber products
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as vulcanization accelerator in rubber products

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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