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Registry of Toxic Effects of Chemical Substances (RTECS)

1H-2,1,3-Benzothiadiazin-4(3H)-one, 3-isopropyl-, 2,2-dioxide

RTECS #

DK9900000

CAS #

25057-89-0

Updated

October 2011

Molecular Weight

240.30

Molecular Formula

C10H12N2O3S

Synonyms

3-(1-Methylethyl)-1H-2,1,3-benzothiazain-4(3H)-one, 2,2-dioxide
3-Isopropyl-1H-2,1,3-benzothiadiazin-4(3H)-one-2,2-dioxide
3-Isopropyl-2,1,3-benzothiadiazinon-(4)-2,2-dioxid (German)
BAS 3510
BAS 351-07H
BAS 3510H
BAS 3512H
BAS 3517H
BAS 351-H
Basagran
Basagran 480
Bendioxide
Bentazon
Bentazone
Pentazone
Pledge

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
specific locus testoral/Drosophila melanogaster2 mmol/LMUREAV 557,53,2004
specific locus test/Drosophila melanogaster0.24 gm/L/48H-continuousMUREAV 653,70,2008

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 25 mg/kg (6D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
AXVMAW 42,261,1988
oral/rat 25 mg/kg (6D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)AXVMAW 42,261,1988
oral/mouse 602 µg/kg (1-21D preg/21D after birth)Reproductive: Specific developmental abnormalities: Urogenital systemTXCYAC 212,165,2005

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 5100 mg/m3/4HPEMNDP 9,65,1991
oral/cat lethal dose (50 percent kill): 500 mg/kgGUCHAZ 6,36,1973
oral/Dog lethal dose (50 percent kill): 450 mg/kgPSSCBG 3,242a,1972
oral/duck lethal dose (50 percent kill): 15 gm/kgDEVEAA 27,78,1973
oral/mouse lethal dose (50 percent kill): 1130 mg/kgYKYUA6 37,319,1986
oral/quail lethal dose (50 percent kill): 720 mg/kgGUCHAZ 6,36,1973
oral/rabbit lethal dose (50 percent kill): 750 mg/kg85DPAN -,-,1971/1976
oral/rat lethal dose (50 percent kill): 1100 mg/kgGUCHAZ 6,36,1973
parenteral/rat lethal dose (50 percent kill): 1100 mg/kgDEVEAA 26,5,1972
skin/rat lethal dose (50 percent kill): 2500 mg/kg85DPAN -,-,1971/1976

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2100 µg/kg/100D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TXCYAC 212,165,2005

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWFEREAC 71,40051,2006
TOXICOLOGY REVIEWFEREAC 71,56378,2006
TOXICOLOGY REVIEWJTPAE7 19,1,2006

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
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