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1H - 2,1,3 - Benzothiadiazin - 4 (3H) - one, 3 - isopropyl - , 2,2 - dioxide

RTECS #: DK9900000

CAS #: 25057-89-0


UPDATE: February 2009 MW: 240.30 MF: C10H12N2O3S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 3 - (1 - Methylethyl) - 1H - 2,1,3 - benzothiazain - 4 (3H) - one, 2,2 - dioxide
  2. 3 - Isopropyl - 2,1,3 - benzothiadiazinon - (4) - 2,2 - dioxid (German)
  3. 3 - Isopropyl - 1H - 2,1,3 - benzothiadiazin - 4 (3H) - one - 2,2 - dioxide
  4. BAS 3510
  5. BAS 351 - H
  6. BAS 3510H
  7. BAS 3512H
  8. BAS 3517H
  1. BAS 351 - 07H
  2. Basagran
  3. Bendioxide
  4. Bentazon
  5. Bentazone
  6. Pentazone
  7. Pledge


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
specific locus test oral
Drosophila melanogaster
2 mmol/L MUREAV 557,53,2004


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 602 g/kg (1-21 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system TXCYAC 212,165,2005
oral
rat
lowest published toxic dose: 25 mg/kg (6 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
AXVMAW 42,261,1988
oral
rat
lowest published toxic dose: 25 mg/kg (6 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) AXVMAW 42,261,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 5,100 mg/m3/4 hour N/R PEMNDP 9,65,1991
oral
cat
lethal dose (50 percent kill): 500 mg/kg N/R GUCHAZ 6,36,1973
oral
duck
lethal dose (50 percent kill): 15 gm/kg N/R DEVEAA 27,78,1973
oral
dog
lethal dose (50 percent kill): 450 mg/kg N/R PSSCBG 3,242a,1972
oral
mouse
lethal dose (50 percent kill): 1,130 mg/kg N/R YKYUA6 37,319,1986
oral
quail
lethal dose (50 percent kill): 720 mg/kg N/R GUCHAZ 6,36,1973
oral
rat
lethal dose (50 percent kill): 1,100 mg/kg N/R GUCHAZ 6,36,1973
oral
rabbit
lethal dose (50 percent kill): 750 mg/kg N/R 85DPAN -,-,1971/1976
parenteral
rat
lethal dose (50 percent kill): 1,100 mg/kg N/R DEVEAA 26,5,1972
skin
rat
lethal dose (50 percent kill): 2,500 mg/kg N/R 85DPAN -,-,1971/1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 2,100 g/kg/100 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXCYAC 212,165,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
FEREAC 71,40051,2006
TOXICOLOGY REVIEW
FEREAC 71,56378,2006
TOXICOLOGY REVIEW
JTPAE7 19,1,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for selective postemergence control of many troublesome broadleaf weeds
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag, Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.6- 1952-
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PSSCBG Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1970-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used for selective postemergence control of many troublesome broadleaf weeds

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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