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Registry of Toxic Effects of Chemical Substances (RTECS)

p-Benzoquinone, 2,3,5,6-tetrachloro-

RTECS #

DK6825000

CAS #

118-75-2

Updated

October 2012

Molecular Weight

245.86

Molecular Formula

C6Cl4O2

Synonyms

1,4-Benzoquinone, 2,3,5,6-tetrachloro-
2,3,5,6-Tetrachloro-1,4-benzoquinone
2,3,5,6-Tetrachloro-2,5-cyclohexadiene-1,4-dione
2,3,5,6-Tetrachloro-p-benzoquinone
Chloranil
Dow Seed Disinfectant No. 5
ENT 3,797
G-25804
G-444E
Geigy-444E
Reranil
Spergon
Spergon I
Spergon technical
Tetrachloro-1,4-benzoquinone
Tetrachlorobenzoquinone
Tetrachloro-p-benzoquinone
Tetrachloro-p-quinone
Tetrachloroquinone
Vulklor

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagefibroblast/human50 µmol/L/1HMUREAV 513,159,2002
mutation in microorganisms/Salmonella typhimurium1100 nmol/plate (+enzymatic activation step)MUREAV 347,37,1995

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 71 gm/kg/78W- intermittentTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 2485 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0530657-1
intraperitoneal/rat lethal dose (50 percent kill): 500 mg/kgPHBUA9 3,337,1955
oral/rat lethal dose (50 percent kill): 4 gm/kgPCOC** -,218,1966
subcutaneous/mouse lowest published toxic dose: 40 mg/kgImmunological Including Allergic: Increase in cellular immune responseCRTOEC 16,688,2003
unreported route/rat lethal dose (50 percent kill): 8450 mg/kgGISAAA 37(5),15,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 15 gm/kg/8D- intermittentBehavioral: Food intake (animal)

Blood: Change in clotting factors

Blood: Changes in leukocyte (WBC) count
JIHTAB 25,98,1943
oral/rat lowest published toxic dose: 66956 mg/kg/22W- continuousLiver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JIHTAB 25,98,1943
oral/rat lowest published toxic dose: 49915 mg/kg/67D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJIHTAB 25,98,1943

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTXCYAC 286,1,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84201; Number of Industries 3; Total Number of Facilities 125; Number of Occupations 8; Total Number of Employees Exposed 2098; Total Number of Female Employees Exposed 761
National Occupational Hazard Survey 1974Hazard Code 84201; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 2; Total Number of Employees Exposed 41

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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