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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzophenone

RTECS #

DI9950000

CAS #

119-61-9

Updated

February 2009

Molecular Weight

182.23

Molecular Formula

C13H10O

Synonyms

alpha-Oxodiphenylmethane
alpha-Oxoditane
Benzene, benzoyl-
Benzoylbenzene
Diphenyl ketone
Diphenylmethanone
Ketone, diphenyl
Phenyl ketone

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA DamageAscites tumor/human10 mg/L/2HFCTOD7 42,1323,2004

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rabbit 600 mg/kg (6-29D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Abortion
NTPTR* TER-99001
oral/rabbit 1080 mg/kg (6-29D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTPTR* TER-99001
oral/rat 4200 mg/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTPTR* TER-98005
oral/rat 1400 mg/kg (6-19D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemNTPTR* TER-98005

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 727 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes
EJTXAZ 9,99,1976
oral/mouse lethal dose (50 percent kill): 2895 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes
EJTXAZ 9,99,1976
oral/rat lethal dose (50 percent kill): >10 gm/kgFCTXAV 11,873,1973
skin/rabbit lethal dose (50 percent kill): 3535 mg/kgFCTXAV 11,873,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic dose: 75 mg/kg/15D- intermittentLiver: Other changes

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)
BECTA6 50,282,1993
intraperitoneal/rat lowest published toxic dose: 150 mg/kg/3D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 193,66,2003
intraperitoneal/rat lowest published toxic dose: 900 mg/kg/3D- intermittentEndocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight
TXAPA9 203,9,2005
oral/mouse lowest published toxic dose: 109 gm/kg/13W- continuousLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 14,221,1994
oral/mouse lowest published toxic dose: 19600 mg/kg/14W- continuousLiver: Other changes

Liver: Changes in liver weight
NTPTR* NIH-00-3943
oral/mouse : 38850 mg/kg/37W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-533
oral/mouse : 21070 mg/kg/86W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-533
oral/mouse : 58800 mg/kg/105W- intermittentLiver: TumorsNTPTR* NTP-TR-533
oral/mouse : 51450 mg/kg/105W- intermittentLiver: Tumors

Blood: Tumors
NTPTR* NTP-TR-533
oral/mouse : 25725 mg/kg/105W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
NTPTR* NTP-TR-533
oral/mouse : 29400 mg/kg/105W- intermittentLiver: Other changes

Blood: Changes in spleen
NTPTR* NTP-TR-533
oral/mouse : 110250 mg/kg/105W- intermittentEye: Other eye effectsNTPTR* NTP-TR-533
oral/mouse lowest published toxic dose: 29400 mg/kg/105W- continuousLiver: Tumors

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
FCTOD7 45,843,2007
oral/mouse lowest published toxic dose: 58800 mg/kg/105W- continuousLiver: Hepatitis (hepatocellular necrosis), zonalFCTOD7 45,843,2007
oral/mouse lowest published toxic dose: 117600 mg/kg/105W- continuousOlfaction: Other olfaction effects

Reproductive: Paternal effects: Testes, epididymis, sperm duct
FCTOD7 45,843,2007
oral/mouse lowest published toxic dose: 25725 mg/kg/105W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
FCTOD7 45,843,2007
oral/mouse lowest published toxic dose: 110250 mg/kg/105W- continuousOlfaction: Other olfaction effectsFCTOD7 45,843,2007
oral/rabbit lowest published toxic dose: 600 mg/kg/24D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* TER-99001
oral/rabbit lowest published toxic dose: 400 mg/kg/16D- intermittentBehavioral: Food intake (animal)NTPTR* TER-99001
oral/rabbit lowest published toxic dose: 450 mg/kg/10D- intermittentBehavioral: Food intake (animal)NTPTR* TER-99001
oral/rabbit lowest published toxic dose: 720 mg/kg/16D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* TER-99001
oral/rat lowest published toxic dose: 1400 mg/kg/14D- intermittentBehavioral: Sleep

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* TER-98005
oral/rat lowest published toxic dose: 1400 mg/kg/14D- intermittentSkin and Appendages: Other: HairNTPTR* TER-98005
oral/rat lowest published toxic dose: 400 mg/kg/4D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* TER-98005
oral/rat lowest published toxic dose: 1000 mg/kg/10D- intermittentBehavioral: Fluid intakeNTPTR* TER-98005
oral/rat : 44100 mg/kg/105W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-533
oral/rat : 26040 mg/kg/62W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-533
oral/rat : 36120 mg/kg/86W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-533
oral/rat : 2100 mg/kg/10W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-533
oral/rat : 29400 mg/kg/70W- intermittentBehavioral: Food intake (animal)NTPTR* NTP-TR-533
oral/rat : 11025 mg/kg/105W- intermittentKidney, Ureter, and Bladder: Bladder tumors

Kidney, Ureter, and Bladder: Kidney tumors

Blood: Leukemia
NTPTR* NTP-TR-533
oral/rat : 11025 mg/kg/105W- intermittentLiver: Other changesNTPTR* NTP-TR-533
oral/rat : 11025 mg/kg/105W- intermittentKidney, Ureter, and Bladder: Other changes

Liver: Change in gall bladder structure or function

Liver: Other changes
NTPTR* NTP-TR-533
oral/rat : 22050 mg/kg/105W- intermittentBlood: LeukemiaNTPTR* NTP-TR-533
oral/rat : 47775 mg/kg/105W- intermittentBlood: TumorsNTPTR* NTP-TR-533
oral/rat lowest published toxic dose: 22050 mg/kg/105W- continuousKidney, Ureter, and Bladder: Kidney tumorsFCTOD7 45,843,2007
oral/rat lowest published toxic dose: 11035 mg/kg/105W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Leukemia
FCTOD7 45,843,2007
oral/rat lowest published toxic dose: 44100 mg/kg/105W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldFCTOD7 45,843,2007
oral/rat lowest published toxic dose: 22050 mg/kg/105W- continuousKidney, Ureter, and Bladder: Kidney tumors

Blood: Leukemia
FCTOD7 45,843,2007
oral/rat lowest published toxic dose: 11035 mg/kg/105W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
FCTOD7 45,843,2007
oral/rat lowest published toxic dose: 14 gm/kg/28D- continuousBlood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count
FCTOD7 29,741,1971
oral/rat lowest published toxic dose: 91 gm/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 14,221,1994
oral/rat lowest published toxic dose: 7350 mg/kg/14W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
NTPTR* NIH-00-3943
oral/rat lowest published toxic dose: 1200 mg/kg/3D- intermittentEndocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight
ARTODN 76,727,2002

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWMUREAV 659,248,2008

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83170; Number of Industries 27; Total Number of Facilities 1809; Number of Occupations 50; Total Number of Employees Exposed 41516; Total Number of Female Employees Exposed 18162
National Occupational Hazard Survey 1974Hazard Code 83170; Number of Industries 8; Total Number of Facilities 1495; Number of Occupations 11; Total Number of Employees Exposed 6944

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000
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