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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzo(ghi)perylene

RTECS #

DI6200500

CAS #

191-24-2

Updated

October 2012

Molecular Weight

276.34

Molecular Formula

C22H12

Synonyms

1,12-Benzoperylene
1,12-Benzperylene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageskin/mouse40 µmol/kgCRNGDP 14,127,1993
DNA Damage/Escherichia coli7077.7 µg/L/3H (+enzymatic activation step)MUREAV 515,85,2002
DNA Damagefibroblast/hamster40 µmol/L/2H (-enzymatic activation step)MUREAV 650,96,2008
morphological transformembryo/mouse0.1 mg/L/12DMUREAV 588,7,2005
mutation in mammalian somatic cellslymphocyte/human80 µg/LMUREAV 371,123,1996
mutation in microorganisms/Salmonella typhimurium2 µg/plate/48H (-enzymatic activation step)FCTXAV 17,141,1979
mutation in microorganisms/Salmonella typhimurium0.5 nmol/plate/48H (-enzymatic activation step)MUREAV 557,99,2004

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration Low: 1 µmol/L/14HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 279,36,2011

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 32,195,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 32,195,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 544,397,2003
TOXICOLOGY REVIEWMUREAV 558,7,2004
TOXICOLOGY REVIEWMUREAV 558,155,2004
TOXICOLOGY REVIEWMUREAV 540,89,2003
TOXICOLOGY REVIEWTOLED5 140-141,353,2003
TOXICOLOGY REVIEWMUREAV 567,401,2004
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 636,4,2007
TOXICOLOGY REVIEWMUREAV 636,36,2007
TOXICOLOGY REVIEWMUREAV 727,1,2011

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
On EPA IRIS database
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