Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Benzonitrile, 3,5-diiodo-4-hydroxy-

RTECS #

DI4025000

CAS #

1689-83-4

Updated

December 2013

Molecular Weight

370.91

Molecular Formula

C7H3I2NO

Synonyms

3,5-Diiodo-4-hydroxybenzonitrile
3,5-Dijod-4-hydroxy-benzonitril (German)
4-Cyano-2,6-diiodophenol
4-Cyano-2,6-dijodphenol (German)
4-Hydroxy-3,5-diiodobenzonitrile
ACP 63303
Actril
Bentrol
Benzonitrile, 4-hydroxy-3,5-diiodo-
CA 69-15
Certrol
Cipotril
Iotox
Ioxynil
Joxynil
M&B 8873
Trevespan

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 6552 mg/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** OTS0571274

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 40 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTXAPA9 247,10,2010
In Vitro/Rat, liver Inhibitor Concentration Low: 100 µmol/L/15MIn Vitro Toxicity Studies: Other assaysTXAPA9 247,10,2010
inhalation/rat lethal concentration (50 percent kill): 380 mg/m3/4HBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0555727
inhalation/rat lethal concentration (50 percent kill): 400 mg/m3HBPTO* 2,1229,2001
intravenous/mouse lethal dose (50 percent kill): 56 mg/kgCSLNX* NX#02818
oral/cat lethal dose (50 percent kill): 75 mg/kgHBPTO* 2,1235,2001
oral/chicken lethal dose (50 percent kill): 200 mg/kg85GYAV -,93,1971
oral/domestic bird lethal dose (50 percent kill): 30 mg/kgHBPTO* 2,1229,2001
oral/duck lethal dose (50 percent kill): 1200 mg/kgHBPTO* 2,1229,2001
oral/guinea pig lethal dose (50 percent kill): 76 mg/kgHBPTO* 2,1235,2001
oral/human lowest published lethal dose: 28 mg/kgBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
ARTODN 37,241,1977
oral/man lowest published lethal dose: 30 mg/kgHBPTO* 2,1236,2001
oral/mouse lethal dose (50 percent kill): 200 mg/kgHBPTO* 2,1229,2001
oral/rabbit lethal dose (50 percent kill): 180 mg/kgHBPTO* 2,1235,2001
oral/rat lethal dose (50 percent kill): 110 mg/kgHBPTO* 2,1229,2001
oral/wild bird lethal dose (50 percent kill): 75 mg/kgPEMNDP 9,496,1991
skin/rat lowest published lethal dose: 210 µg/kgGUCHAZ 6,304,1973
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 120 mg/kg30ZDA9 -,149,1971
unreported route/mouse lethal dose (50 percent kill): 230 µg/kgGUCHAZ 6,304,1973
unreported route/rabbit lethal dose (50 percent kill): 180 µg/kgGUCHAZ 6,304,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 980 mg/kg/14W- continuousLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight
NNGADV 16,349,1991
oral/mouse lowest published toxic dose: 1365 mg/kg/78W- continuousGastrointestinal: Other changes

Liver: Other changes
NNGADV 16,349,1991
oral/mouse lowest published toxic dose: 2737.5 mg/kg/78W- continuousLiver: Other changes

Endocrine: Thyroid weight (goiter)
HBPTO* 2,1235,2001
oral/mouse lowest published toxic dose: 3650 mg/kg/2Y- continuousEndocrine: Evidence of thyroid hyperfunctionHBPTO* 2,1235,2001
oral/rat lowest published toxic dose: 980 mg/kg/14W- continuousLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
NNGADV 16,349,1991
oral/rat lowest published toxic dose: 21900 mg/kg/2Y- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
NNGADV 16,349,1991

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWHUTOX* -,551,1996

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP