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Benzonitrile, 3,5 - diiodo - 4 - hydroxy -

RTECS #: DI4025000

CAS #: 1689-83-4


UPDATE: May 2009 MW: 370.91 MF: C7H3I2NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 3,5 - Diiodo - 4 - hydroxybenzonitrile
  2. 3,5 - Dijod - 4 - hydroxy - benzonitril (German)
  3. 4 - Cyano - 2,6 - diiodophenol
  4. 4 - Cyano - 2,6 - dijodphenol (German)
  5. 4 - Hydroxy - 3,5 - diiodobenzonitrile
  6. ACP 63303
  7. Actril
  8. Bentrol
  9. Benzonitrile, 4 - hydroxy - 3,5 - diiodo -
  1. CA 69 - 15
  2. Certrol
  3. Cipotril
  4. Iotox
  5. Ioxynil
  6. Joxynil
  7. M&B 8873
  8. Trevespan


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 6,552 mg/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** OTS0571274


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 380 mg/m3/4 hour Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0555727
inhalation
rat
lethal concentration (50 percent kill): 400 mg/m3 N/R HBPTO* 2,1229,2001
intravenous
mouse
lethal dose (50 percent kill): 56 mg/kg N/R CSLNX* NX#02818
oral
domestic bird
lethal dose (50 percent kill): 30 mg/kg N/R HBPTO* 2,1229,2001
oral
wild bird
lethal dose (50 percent kill): 75 mg/kg N/R PEMNDP 9,496,1991
oral
cat
lethal dose (50 percent kill): 75 mg/kg N/R HBPTO* 2,1235,2001
oral
chicken
lethal dose (50 percent kill): 200 mg/kg N/R 85GYAV -,93,1971
oral
duck
lethal dose (50 percent kill): 1,200 mg/kg N/R HBPTO* 2,1229,2001
oral
guinea pig
lethal dose (50 percent kill): 76 mg/kg N/R HBPTO* 2,1235,2001
oral
human
lowest published lethal dose: 28 mg/kg Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
ARTODN 37,241,1977
oral
man
lowest published lethal dose: 30 mg/kg N/R HBPTO* 2,1236,2001
oral
mouse
lethal dose (50 percent kill): 200 mg/kg N/R HBPTO* 2,1229,2001
oral
rat
lethal dose (50 percent kill): 110 mg/kg N/R HBPTO* 2,1229,2001
oral
rabbit
lethal dose (50 percent kill): 180 mg/kg N/R HBPTO* 2,1235,2001
skin
rat
lowest published lethal dose: 210 g/kg N/R GUCHAZ 6,304,1973
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 120 mg/kg N/R 30ZDA9 -,149,1971
unreported route
mouse
lethal dose (50 percent kill): 230 g/kg N/R GUCHAZ 6,304,1973
unreported route
rabbit
lethal dose (50 percent kill): 180 g/kg N/R GUCHAZ 6,304,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 980 mg/kg/14 week- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight
NNGADV 16,349,1991
oral
mouse
lowest published toxic dose: 1,365 mg/kg/78 week- continuous Gastrointestinal: Other changes

Liver: Other changes
NNGADV 16,349,1991
oral
mouse
lowest published toxic dose: 2,737.5 mg/kg/78 week- continuous Liver: Other changes

Endocrine: Thyroid weight (goiter)
HBPTO* 2,1235,2001
oral
mouse
lowest published toxic dose: 3,650 mg/kg/2 year- continuous Endocrine: Evidence of thyroid hyperfunction HBPTO* 2,1235,2001
oral
rat
lowest published toxic dose: 980 mg/kg/14 week- continuous Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
NNGADV 16,349,1991
oral
rat
lowest published toxic dose: 21,900 mg/kg/2 year- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
NNGADV 16,349,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
HUTOX* -,551,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HUTOX*
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-

Used as a contact herbicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Human Data

Click Here for Additional Information about RTECS

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