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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzonitrile, 2,6-dichloro-

RTECS #

DI3500000

CAS #

1194-65-6

Updated

December 2013

Molecular Weight

172.01

Molecular Formula

C7H3Cl2N

Synonyms

2,6-DBN
2,6-Dichlorbenzonitril (German)
2,6-Dichlorobenzonitrile
Casoron
Casoron 133
Code H 133
Cyclomec
DBN (the herbicide)
Decabane
Dichlobenil
DU-Sprex
H 1313
H 133
NIA 5996
Niagara 5,996
Norosac
Prefix D

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 260 µg/kg/39D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
AAATAP 122,107,1979
subcutaneous/mouse lowest published toxic dose: 260 µg/kg/39D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Tumors at site of application
AAATAP 122,107,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 360 mg/kgFRPSAX 41,41,1986
intraperitoneal/mouse lowest published toxic dose: 25 mg/kgOlfaction: Other olfaction effectsTXAPA9 249,101,2010
oral/guinea pig lethal dose (50 percent kill): 681 mg/kgPCOC** -,337,1966
oral/mouse lethal dose (50 percent kill): 2056 mg/kg28ZEAL 5,73,1976
oral/rabbit lethal dose (50 percent kill): 270 mg/kgBehavioral: Somnolence (general depressed activity)

Liver: Other changes
FCTXAV 6,261,1968
oral/rat lethal dose (50 percent kill): 2710 mg/kgRREVAH 10,97,1965
skin/mouse Lethal dose: >200 mg/kgOlfaction: Deviated nasal septum

Olfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Lipids including transport
NRTXDN 15,287,1994
skin/rabbit lethal dose (50 percent kill): 1350 mg/kgGUCHAZ 6,177,1973
subcutaneous/frog lowest published toxic dose: 50 mg/kgOlfaction: Other olfaction effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins
AQUTO* 69,259,2004
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1 gm/kg30ZDA9 -,144,1971
unreported route/rat lethal dose (50 percent kill): 500 mg/kg30ZDA9 -,145,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 50 mg/kg/3D- intermittentOlfaction: Change in olfactory nerve

Blood: Other changes
ARTODN 76,104,2002
skin/mouse lowest published toxic dose: 1 gm/kg/5D- intermittentOlfaction: Deviated nasal septum

Olfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Lipids including transport
NRTXDN 15,287,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWFEREAC 73,50563,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,111,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 24030; Number of Industries 1; Total Number of Facilities 40; Number of Occupations 1; Total Number of Employees Exposed 200

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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