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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzonitrile

RTECS #

DI2450000

CAS #

100-47-0

Updated

October 2011

Molecular Weight

103.13

Molecular Formula

C7H5N

Synonyms

Benzene, cyano-
Benzenenitrile
Benzoic acid nitrile
Cyanobenzene
Fenylkyanid (Czech)
Phenyl cyanide

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H moderateFCTXAV 17,723,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testovary/hamster0.01 µmol/L/18HARTODN 78,49,2004
micronucleus testfibroblast/hamster0.1 µmol/LNSAPCC 369(Suppl 1),R127,2004
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster168 ppmMUREAV 403,149,1998
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae1580 mg/LMUREAV 241,255,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 1800 mg/m3GTPZAB 21(6),34,1977
inhalation/rat Lowest published lethal concentration: 950 ppm/8HLung, Thorax, or Respiration: Other changesAMRL** TR-74-78,1974
intraperitoneal/mouse lethal dose (50 percent kill): 400 mg/kgFCTXAV 17,723,1979
intraperitoneal/rabbit lethal dose (50 percent kill): 1250 mg/kgFCTXAV 17,723,1979
intraperitoneal/rat lethal dose (50 percent kill): 740 mg/kgEye: Ptosis

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Acute pulmonary edema
APFRAD 48,23,1990
oral/cat lethal dose (50 percent kill): 800 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
FCTXAV 17,723,1979
oral/mammal (species unspecified) lethal dose (50 percent kill): 800 mg/kgGTPZAB 32(10),25,1988
oral/mouse lethal dose (50 percent kill): 971 mg/kgNEZAAQ 39,423,1984
oral/rabbit lethal dose (50 percent kill): 800 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
FCTXAV 17,723,1979
oral/rat lowest published lethal dose: 720 mg/kgAMRL** TR-74-78,1974
skin/rabbit lethal dose (50 percent kill): 1250 mg/kgFCTXAV 17,723,1979
skin/rat lethal dose (50 percent kill): 1200 mg/kgAMRL** TR-74-78,1974
subcutaneous/frog lowest published lethal dose: 1700 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Cardiac: Other changes

Lung, Thorax, or Respiration: Dyspnea
AIPTAK 5,161,1899
subcutaneous/pigeon lowest published lethal dose: 500 mg/kgFCTXAV 17,723,1979
subcutaneous/rabbit lowest published lethal dose: 200 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
AIPTAK 5,161,1899

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lowest published toxic concentration: 70 mg/m3/4H/19W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainGTPZAB 21(6),34,1977
inhalation/rat lowest published toxic concentration: 70 mg/m3/4H/19W- intermittentLiver: Liver function tests impaired

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
GTPZAB 21(3),40,1977

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUTAEX 20,389,2005
TOXICOLOGY REVIEWMUREAV 628,67,2007
TOXICOLOGY REVIEWMUTAEX 26,199,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code A1153; Number of Industries 1; Total Number of Facilities 17; Number of Occupations 1; Total Number of Employees Exposed 34

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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