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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzoin

RTECS #

DI1590000

CAS #

119-53-9

Updated

July 2013

Molecular Weight

212.26

Molecular Formula

C14H12O2

Synonyms

2-Hydroxy-2-phenylacetophenone
Acetophenone, 2-hydroxy-2-phenyl-
alpha-Hydroxy-alpha-phenylacetophenone
alpha-Hydroxybenzyl phenyl ketone
Benzoylphenylcarbinol
Bitter almond oil camphor
Ethanone, 2-hydroxy-1,2-diphenyl-
Fenyl-alpha-hydroxybenzylketon (Czech)
Ketone, alpha-hydroxybenzyl phenyl
NCI-C50011
WY-42956

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 50%/10D- intermittentVCVGK* -,473,1994

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster20 mg/LPMRSDJ 5,427,1985
DNA Damageliver/rat63700 µg/LPMRSDJ 5,353,1985
DNA Damageintraperitoneal/rat500 mg/kgMUREAV 224,379,1989
gene conversion and mitotic recombination/Saccharomyes cerevisiae250 mg/LPMRSDJ 5,271,1985
micronucleus testlung/hamster5000 µmol/L/6H (+enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster2500 µmol/L/48H (-enzymatic activation step)MUTAEX 26,709,2011
mutation in mammalian somatic cellslymphocyte/mouse62500 µg/LPMRSDJ 5,587,1985
mutation in microorganismslymphocyte/mouse10 mg/L (+enzymatic activation step)PMRSDJ 5,569,1985
mutation in microorganisms/Saccharomyes cerevisiae25 mg/L (+enzymatic activation step)PMRSDJ 5,257,1985
mutation in microorganisms/Salmonella typhimurium750 µg/plate (+enzymatic activation step)PMRSDJ 5,187,1985
phage inhibition capacity/Escherichia coli15600 ng/wellMUREAV 260,349,1991
sister chromatid exchangeovary/hamster500 mg/LEMMUEG 13,133,1989
Unscheduled DNA Synthesisintraperitoneal/mouse500 mg/kgMUREAV 224,379,1989
Unscheduled DNA Synthesisliver/rat1 mmol/LPMRSDJ 5,371,1985
Unscheduled DNA Synthesisoral/rat1 gm/kgMUREAV 320,189,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 870 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
VCVGK* -,473,1994
intraperitoneal/rat lethal dose (50 percent kill): 870 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
VCVGK* -,473,1994
oral/mouse lowest published lethal dose: 10000 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
VCVGK* -,473,1994
oral/mouse lethal dose (50 percent kill): >3 gm/kgBehavioral: Somnolence (general depressed activity)IYKEDH 15,359,1984
oral/rat lowest published lethal dose: 10000 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
VCVGK* -,473,1994
oral/rat lethal dose (50 percent kill): 10 gm/kgFCTXAV 11,871,1973
skin/rabbit lethal dose (50 percent kill): 8870 mg/kgFCTXAV 11,871,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 60000 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Proteinuria
VCVGK* -,473,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 672,10,2009
TOXICOLOGY REVIEWMUREAV 672,17,2009
TOXICOLOGY REVIEWMUTAEX 23,271,2008

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X9855; Number of Industries 1; Total Number of Facilities 6; Number of Occupations 1; Total Number of Employees Exposed 42; Total Number of Female Employees Exposed 18
National Occupational Exposure Survey 1983Hazard Code 80585; Number of Industries 4; Total Number of Facilities 189; Number of Occupations 16; Total Number of Employees Exposed 26840; Total Number of Female Employees Exposed 22514
National Occupational Hazard Survey 1974Hazard Code 80585; Number of Industries 25; Total Number of Facilities 2083; Number of Occupations 30; Total Number of Employees Exposed 151846

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-204,1980
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