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Benzoin

RTECS #: DI1590000

CAS #: 119-53-9


UPDATE: May 2009 MW: 212.26 MF: C14H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Hydroxy - 2 - phenylacetophenone
  2. Acetophenone, 2 - hydroxy - 2 - phenyl -
  3. Benzoylphenylcarbinol
  4. Bitter almond oil camphor
  5. Ethanone, 2 - hydroxy - 1,2 - diphenyl -
  6. Fenyl - alpha - hydroxybenzylketon (Czech)
  1. Ketone, alpha - hydroxybenzyl phenyl
  2. NCI - C50011
  3. WY - 42956
  4. alpha - Hydroxybenzyl phenyl ketone
  5. alpha - Hydroxy - alpha - phenylacetophenone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
50%/1 0 day- intermittent VCVGK* -,473,1994


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 20 mg/L PMRSDJ 5,427,1985
DNA damage rat liver 63,700 g/L PMRSDJ 5,353,1985
DNA damage intraperitoneal
rat
500 mg/kg MUREAV 224,379,1989
unscheduled DNA synthesis intraperitoneal
mouse
500 mg/kg MUREAV 224,379,1989
unscheduled DNA synthesis rat liver 1 mmol/L PMRSDJ 5,371,1985
unscheduled DNA synthesis oral
rat
1 gm/kg MUREAV 320,189,1994
mutation in microorganisms mouse lymphocyte 10 mg/L (+enzymatic activation step) PMRSDJ 5,569,1985
mutation in microorganisms Salmonella typhimurium 750 g/plate (+enzymatic activation step) PMRSDJ 5,187,1985
mutation in microorganisms Saccharomyes cerevisiae 25 mg/L (+enzymatic activation step) PMRSDJ 5,257,1985
gene conversion and mitotic recombination Saccharomyes cerevisiae 250 mg/L PMRSDJ 5,271,1985
mutation in mammalian somatic cells mouse lymphocyte 62,500 g/L PMRSDJ 5,587,1985
phage inhibition capacity Escherichia coli 15,600 ng/well MUREAV 260,349,1991
sister chromatid exchange hamster ovary 500 mg/L EMMUEG 13,133,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 870 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
VCVGK* -,473,1994
intraperitoneal
rat
lethal dose (50 percent kill): 870 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
VCVGK* -,473,1994
oral
mouse
lethal dose (50 percent kill): >3 gm/kg Behavioral: Somnolence (general depressed activity) IYKEDH 15,359,1984
oral
mouse
lowest published lethal dose: 10,000 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
VCVGK* -,473,1994
oral
rat
lethal dose (50 percent kill): 10 gm/kg N/R FCTXAV 11,871,1973
oral
rat
lowest published lethal dose: 10,000 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
VCVGK* -,473,1994
skin
rabbit
lethal dose (50 percent kill): 8,870 mg/kg N/R FCTXAV 11,871,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 60,000 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Proteinuria
VCVGK* -,473,1994
skin
rabbit
lowest published toxic concentration: 50 pph/10 day- intermittent Skin and Appendages: Other: Hair VCVGK* -,473,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
MUREAV 672,17,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80585;
Number of Industries 25;
Total Number of Facilities 2,083;
Number of Occupations 30;
Total Number of Employees Exposed 151,846
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9855;
Number of Industries 1;
Total Number of Facilities 6;
Number of Occupations 1;
Total Number of Employees Exposed 42;
Total Number of Female Employees Exposed 18
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80585;
Number of Industries 4;
Total Number of Facilities 189;
Number of Occupations 16;
Total Number of Employees Exposed 26,840;
Total Number of Female Employees Exposed 22,514


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as photopolymerization catalyst, flavoring, and raw material for emulsifiers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-204,1980


REFERENCES:

CODEN
REFERENCE

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as photopolymerization catalyst, flavoring, and raw material for emulsifiers

NIOSH PROFILE (BENZOIN), SRC, 3/81

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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