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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzoic acid, sodium salt

RTECS #

DH6650000

CAS #

532-32-1

Updated

April 2012

Molecular Weight

144.11

Molecular Formula

C7H5O2·Na

Synonyms

Antimol
Benzoan sodny (Czech)
Benzoate of soda
Benzoate sodium
Benzoesaeure (na-salz) (German)
E 211
Sobenate
Sodium benzoate
Sodium benzoic acid

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 10%/1H open irritation testDERAAC 26,734,1984
skin /human 0.5%/20MJAADDB 26,734,1984

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster1 gm/LATSUDG 4,41,1980
Cytogenetic Analysisfibroblast/hamster2 gm/L/48HMUREAV 48,337,1977
Cytogenetic Analysislymphocyte/human6.25 mg/L/24HFCTOD7 49,763,2011
DNA Damagelymphocyte/human6.25 mg/L/1HFCTOD7 49,763,2011
micronucleus testlymphocyte/human25 mg/L/48HFCTOD7 49,763,2011
sister chromatid exchangelymphocyte/human10 mmol/LMUREAV 241,109,1990
sister chromatid exchangelymphocyte/human6.25 mg/L/24HFCTOD7 49,763,2011
sister chromatid exchangelymphocyte/human8 mmol/L/72HFCTOD7 46,2390,2008

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 3 gm/kg (12-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TXAPA9 19,373,1971
intraperitoneal/rat 300 mg/kg (12-14D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTXAPA9 19,373,1971
oral/rat 44 gm/kg (1-22D pregnant)Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ESKHA5 (96),47,1978
oral/rat 44 gm/kg (1-22D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)ESKHA5 (96),47,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rabbit, ocular Inhibitor Concentration (50 percent kill): 0.03 gm/L/10MIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 3,329,1989
intramuscular/mouse lethal dose (50 percent kill): 2306 mg/kgJPETAB 117,307,1956
intraperitoneal/guinea pig lowest published lethal dose: 1400 mg/kgHBAMAK 4,1313,1935
intravenous/mouse lethal dose (50 percent kill): 1440 mg/kgMECHAN 6,290,1963
intravenous/rat lethal dose (50 percent kill): 1714 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
JAPMA8 31,253,1942
oral/Dog lethal dose (50 percent kill): 2 gm/kgFAONAU 53A,34,1974
oral/mouse lethal dose (50 percent kill): 1600 mg/kgBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea
GISAAA 51(1),75,1986
oral/rabbit lethal dose (50 percent kill): 2 gm/kgFAONAU 53A,34,1974
oral/rat lethal dose (50 percent kill): 4070 mg/kgJIHTAB 30,63,1948
subcutaneous/frog lowest published lethal dose: 100 mg/kgHBAMAK 4,1313,1935
subcutaneous/guinea pig lowest published lethal dose: 1 gm/kgGISAAA 28(1),45,1963
subcutaneous/rabbit lethal dose (50 percent kill): 2 gm/kgFAONAU 53A,34,1974
subcutaneous/rat lethal dose (50 percent kill): 2 gm/kgGISAAA 28(1),45,1963

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 45 gm/kg/10D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOLED5 69,171,1993
oral/rat lowest published toxic dose: 35200 mg/kg/22D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/rat lowest published toxic dose: 27370 mg/kg/10D- continuousLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TOLED5 69,171,1993
oral/rat lowest published toxic dose: 84 gm/kg/28D- continuousBehavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIPTAK 144,120,1963
oral/rat lowest published toxic dose: 137 gm/kg/13W- continuousBehavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TRENAF 42,285,1991

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHUTOX* -,259,1996
TOXICOLOGY REVIEWTXAPA9 243,225,2010

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,297,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1192; Number of Industries 2; Total Number of Facilities 31; Number of Occupations 2; Total Number of Employees Exposed 430; Total Number of Female Employees Exposed 288
National Occupational Exposure Survey 1983Hazard Code 80214; Number of Industries 143; Total Number of Facilities 20457; Number of Occupations 125; Total Number of Employees Exposed 533161; Total Number of Female Employees Exposed 199915
National Occupational Hazard Survey 1974Hazard Code 80214; Number of Industries 84; Total Number of Facilities 13289; Number of Occupations 69; Total Number of Employees Exposed 92390

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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