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Benzoic acid, p - nitro -

RTECS #: DH5075000

CAS #: 62-23-7


UPDATE: November 2007 MW: 167.13 MF: C7H5NO4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1 - Carboxy - 4 - nitrobenzene
  2. 4 - Nitrobenzoic acid
  3. 4 - Nitrodracylic acid
  1. Kyselina p - nitrobenzoova (Czech)
  2. p - Nitrobenzenecarboxylic acid
  3. p - Nitrobenzoic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg/24 hour moderate 85JCAE -,739,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium
400 mg/kg/4 day PNASA6 72,4607,1975
cytogenetic analysis hamster ovary 875 mg/L ENMUDM 9,269,1987
DNA repair Bacillus subtilis 50 g/disc MUREAV 170,11,1986
mutation in microorganisms Salmonella typhimurium 100 g/plate (+enzymatic activation step) MUREAV 137,71,1984
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) ENMUDM 9(Suppl 9),1,1987
sister chromatid exchange hamster ovary 1 gm/L ENMUDM 9,269,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 132.3 gm/kg (21 week prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB90253766


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 45,063 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
NTPTR* NTP-TR-442,1994
oral
rat
lowest published toxic dose: 43,260 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Other reproductive system tumors
NTIS** PB95-226254


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 880 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Aggression
CRSBAW 160,1097,1966
intraperitoneal
rat
lethal dose (50 percent kill): 1,210 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold
CRSBAW 160,1097,1966
intravenous
mouse
lethal dose (50 percent kill): 770 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Aggression
CRSBAW 160,1097,1966
oral
rat
lethal dose (50 percent kill): 1,960 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold
CRSBAW 160,1097,1966
parenteral
mouse
lethal dose (50 percent kill): 1,470 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Aggression
CRSBAW 160,1097,1966
parenteral
rat
lethal dose (50 percent kill): 1,960 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold
CRSBAW 160,1097,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 56 gm/kg/14 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thymus weight
NTPTR* NTP-TR-442,1994
oral
mouse
lowest published toxic dose: 11,050 mg/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-442,1994
oral
mouse
lowest published toxic dose: 264.6 gm/kg/21 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB86167053
oral
rat
lowest published toxic dose: 11,760 mg/kg/14 day- continuous Blood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-442,1994
oral
rat
lowest published toxic dose: 10,400 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
NTPTR* NTP-TR-442,1994
oral
rat
lowest published toxic dose: 90,125 mg/kg/103 week- continuous Blood: Leukemia

Tumorigenic: Active as anti-cancer agent
NTIS** PB95-226254


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83217;
Number of Industries 2;
Total Number of Facilities 32;
Number of Occupations 3;
Total Number of Employees Exposed 396
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83217;
Number of Industries 31;
Total Number of Facilities 3,573;
Number of Occupations 46;
Total Number of Employees Exposed 42,700;
Total Number of Female Employees Exposed 12,407


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of anaesthetics, antibiotics, and azo dyes
NTP Carcinogenesis Studies (feed);some evidence:rat NTPTR* NTP-TR-442,1994
NCI Carcinogenesis Studies (feed);equivocal evidence:rat
NCI Carcinogenesis Studies (feed);no evidence:mouse


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-

Used in manufacture of anaesthetics, antibiotics, and azo dyes

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

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