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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzoic acid, p-nitro-

RTECS #

DH5075000

CAS #

62-23-7

Updated

November 2007

Molecular Weight

167.13

Molecular Formula

C7H5NO4

Synonyms

1-Carboxy-4-nitrobenzene
4-Nitrobenzoic acid
4-Nitrodracylic acid
Kyselina p-nitrobenzoova (Czech)
p-Nitrobenzenecarboxylic acid
p-Nitrobenzoic acid

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,739,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat400 mg/kg/4DPNASA6 72,4607,1975
Cytogenetic Analysisovary/hamster875 mg/LENMUDM 9,269,1987
DNA repair/Bacillus subtilis50 µg/discMUREAV 170,11,1986
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)MUREAV 137,71,1984
mutation in microorganisms/Salmonella typhimurium1 mg/plate (-enzymatic activation step)ENMUDM 9(Suppl 9),1,1987
sister chromatid exchangeovary/hamster1 gm/LENMUDM 9,269,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 132.3 gm/kg (21W prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB90253766

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 45063 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
NTPTR* NTP-TR-442,1994
oral/rat lowest published toxic dose: 43260 mg/kg/103W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Other reproductive system tumors
NTIS** PB95-226254

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 880 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Aggression
CRSBAW 160,1097,1966
intraperitoneal/rat lethal dose (50 percent kill): 1210 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold
CRSBAW 160,1097,1966
intravenous/mouse lethal dose (50 percent kill): 770 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Aggression
CRSBAW 160,1097,1966
oral/rat lethal dose (50 percent kill): 1960 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold
CRSBAW 160,1097,1966
parenteral/mouse lethal dose (50 percent kill): 1470 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Aggression
CRSBAW 160,1097,1966
parenteral/rat lethal dose (50 percent kill): 1960 mg/kgEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold
CRSBAW 160,1097,1966

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 56 gm/kg/14D- continuousLiver: Changes in liver weight

Endocrine: Changes in thymus weight
NTPTR* NTP-TR-442,1994
oral/mouse lowest published toxic dose: 11050 mg/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-442,1994
oral/mouse lowest published toxic dose: 264.6 gm/kg/21W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB86167053
oral/rat lowest published toxic dose: 90125 mg/kg/103W- continuousBlood: Leukemia

Tumorigenic: Active as anti-cancer agent
NTIS** PB95-226254
oral/rat lowest published toxic dose: 11760 mg/kg/14D- continuousBlood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-442,1994
oral/rat lowest published toxic dose: 10400 mg/kg/13W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
NTPTR* NTP-TR-442,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83217; Number of Industries 31; Total Number of Facilities 3573; Number of Occupations 46; Total Number of Employees Exposed 42700; Total Number of Female Employees Exposed 12407
National Occupational Hazard Survey 1974Hazard Code 83217; Number of Industries 2; Total Number of Facilities 32; Number of Occupations 3; Total Number of Employees Exposed 396

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Studies (feed);equivocal evidence:rat
NCI Carcinogenesis Studies (feed);no evidence:mouse
NTP Carcinogenesis Studies (feed);some evidence:rat NTPTR* NTP-TR-442,1994
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