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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzoic acid, methyl ester

RTECS #

DH3850000

CAS #

93-58-3

Updated

November 2009

Molecular Weight

136.16

Molecular Formula

C8H8O2

Synonyms

Essence of niobe
Methyl benzenecarboxylate
Methyl benzoate
Methylester kyseliny benzoove (Czech)
Niobe oil
Oil of niobe

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/guinea pig lethal dose (50 percent kill): 4100 mg/kgLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
HPV137 -,-,2003
oral/guinea pig lethal dose (50 percent kill): 4100 mg/kgFCTXAV 12,937,1974
oral/guinea pig lethal dose (50 percent kill): 4100 mg/kgLung, Thorax, or Respiration: Emphysema

Liver: Other changes
HPV141 -,-,2001
oral/mouse lethal dose (50 percent kill): 3000 mg/kgLung, Thorax, or Respiration: Emphysema

Liver: Other changes
HPV141 -,-,2001
oral/mouse lethal dose (50 percent kill): 3000 mg/kgLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
HPV137 -,-,2003
oral/mouse lethal dose (50 percent kill): 3330 mg/kgBehavioral: Tremor

Behavioral: Excitement
FCTXAV 2,327,1964
oral/rabbit lethal dose (50 percent kill): 2170 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Skin and Appendages: Other: Hair
JPETAB 84,358,1945
oral/rabbit lethal dose (50 percent kill): 2170 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HPV141 -,-,2001
oral/rat lethal dose (50 percent kill): 3500 mg/kgLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
HPV137 -,-,2003
oral/rat lethal dose (50 percent kill): >1000 ppm/8HHPV141 -,-,2001
oral/rat lethal dose (50 percent kill): 1177 mg/kgBehavioral: Change in motor activity (specific assay)

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair
FAVUAI 18,69,1986
oral/rat lethal dose (50 percent kill): 3430 mg/kgHPV141 -,-,2001
oral/rat lethal dose (50 percent kill): 3500 mg/kgLung, Thorax, or Respiration: Emphysema

Liver: Other changes
HPV141 -,-,2001
oral/rat lethal dose (50 percent kill): 2170 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HPV141 -,-,2001
skin/cat lowest published lethal dose: 10 gm/kgBehavioral: Tremor

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands
JPETAB 84,358,1945
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgSkin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV141 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 17400 mg/kg/60D- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 49(11),85,1984
unreported route/rat lowest published toxic dose: 4995 mg/kg/45D- intermittentBlood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
HPV137 -,-,2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M1650; Number of Industries 51; Total Number of Facilities 4188; Number of Occupations 60; Total Number of Employees Exposed 73641; Total Number of Female Employees Exposed 25030
National Occupational Hazard Survey 1974Hazard Code M1650; Number of Industries 3; Total Number of Facilities 61; Number of Occupations 6; Total Number of Employees Exposed 1002

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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