RTECS:DH3565000 The Registry of Toxic Effects of Chemical Substances

Benzoic acid, 2 - ( ( ( ( (4 - methoxy - 6 - methyl - 1,3,5 - triazin - 2 - yl) methylamino) carbonyl) amino) sulfonyl) - , methyl ester

RTECS #: DH3565000

CAS #: 101200-48-0

UPDATE: November 2008 MW: 395.43 MF: C₁₅H₁₇N₅O₆S

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

DPX - L 5300

Express

Express 75 DF

L 5300

Matrix

Sulfmethmeton - methyl

Tribenuron methyl

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lethal concentration (50 percent kill): >5.0 gm/m³/4 hour N/R FEREAC 69,40909,2004
oral
quail lethal dose (50 percent kill): >2,250 mg/kg N/R PEMNDP 9,840,1991
oral
rat lethal dose (50 percent kill): >5,000 mg/kg N/R FEREAC 69,40909,2004
skin
rabbit lethal dose (50 percent kill): >2,000 mg/kg N/R FEREAC 69,40909,2004

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
dog lowest published toxic dose: 6,797 mg/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 69,40909,2004
oral
dog lowest published toxic dose: 17,870.4 mg/kg/1 year- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 69,40909,2004
oral
mouse lowest published toxic dose: 15,750 mg/kg/90 day- continuous Liver: Other changes

Blood: Changes in spleen FEREAC 69,40909,2004
oral
mouse lowest published toxic dose: 102,562.5 mg/kg/1.5 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 69,40909,2004
oral
rat lowest published toxic dose: 11,025 mg/kg/90 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 69,40909,2004
oral
rat lowest published toxic dose: 6,935 mg/kg/2 year- continuous Behavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 69,40909,2004
oral
rat lowest published toxic dose: 43,800 mg/kg/2 year- continuous Skin and Appendages: Other: Breast

Skin and Appendages: Tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously FEREAC 69,40909,2004

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FEREAC 72,11784,2007

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,397,1998

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as selective postemergence broadleaf weed control in wheat, barley

RTECS Compound Description:
Agricultural Chemical

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SYNONYMS:
DPX - L 5300 Express Express 75 DF L 5300	Matrix Sulfmethmeton - methyl Tribenuron methyl

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lethal concentration (50 percent kill): >5.0 gm/m³/4 hour	N/R	FEREAC 69,40909,2004
oral quail	lethal dose (50 percent kill): >2,250 mg/kg	N/R	PEMNDP 9,840,1991
oral rat	lethal dose (50 percent kill): >5,000 mg/kg	N/R	FEREAC 69,40909,2004
skin rabbit	lethal dose (50 percent kill): >2,000 mg/kg	N/R	FEREAC 69,40909,2004

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral dog	lowest published toxic dose: 6,797 mg/kg/90 day- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FEREAC 69,40909,2004
oral dog	lowest published toxic dose: 17,870.4 mg/kg/1 year- continuous	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FEREAC 69,40909,2004
oral mouse	lowest published toxic dose: 15,750 mg/kg/90 day- continuous	Liver: Other changes Blood: Changes in spleen	FEREAC 69,40909,2004
oral mouse	lowest published toxic dose: 102,562.5 mg/kg/1.5 year- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FEREAC 69,40909,2004
oral rat	lowest published toxic dose: 11,025 mg/kg/90 day- continuous	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FEREAC 69,40909,2004
oral rat	lowest published toxic dose: 6,935 mg/kg/2 year- continuous	Behavioral: Food intake (animal) Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FEREAC 69,40909,2004
oral rat	lowest published toxic dose: 43,800 mg/kg/2 year- continuous	Skin and Appendages: Other: Breast Skin and Appendages: Tumors Tumorigenic: Tumor types after systemic administration not seen spontaneously	FEREAC 69,40909,2004

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		FEREAC 72,11784,2007

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF	PESTICIDES: Active registration	RBREV* -,397,1998

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
N/R	N/R	N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
FEREAC	Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
PEMNDP	Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV*	Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998