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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzoic acid

RTECS #

DG0875000

CAS #

65-85-0

Updated

December 2013

Molecular Weight

122.13

Molecular Formula

C7H6O2

Synonyms

Acide benzoique (French)
Acido benzoico (Italian)
Benzenecarboxylic acid
Benzeneformic acid
Benzenemethanoic acid
Benzoate
Benzoesaeure (German)
Carboxybenzene
Dracylic acid
E 210
HA 1 (acid)
Kyselina benzoova (Czech)
Phenylcarboxylic acid
Phenylformic acid
Retarder BA
Retardex
Salvo liquid
Salvo powder
Tenn-Plas

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 22 mg/3D- intermittent moderate85DKA8 -,127,1977
skin /human 0.25%/1H open irritation testADVEA4 26,734,1984
skin /human 0.76%/40M mildCODEDG 33,177,1995

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelymphocyte/human5 mmol/LFCTOD7 48,1239,2010
DNA inhibitionlymphocyte/human5 mmol/LPNASA6 79,1171,1982
mutation in microorganisms/Escherichia coli10 mmol/L (-enzymatic activation step)ZBPIA9 112,226,1959
other mutation test systemsoral/Drosophila melanogaster50 mmol/LFCTOD7 46,1034,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/hpcInhibitor Concentration Low: 0.25 gm/L/30MIn Vitro Toxicity Studies: Other assaysJOETD7 137,914,2011
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 21 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intraperitoneal/guinea pig lowest published lethal dose: 1400 mg/kgHBTXAC 5,23,1959
intraperitoneal/mouse lethal dose (50 percent kill): 1460 mg/kgCRSBAW 160,1097,1966
intraperitoneal/rat lethal dose (50 percent kill): 1600 mg/kgBCFAAI 112,53,1973
intravenous/rat lethal dose (50 percent kill): 1700 mg/kgAPYPAY 12,173,1961
oral/guinea pig lowest published lethal dose: 2 gm/kgMMWOAU 77,13,1930
oral/man lowest published lethal dose: 500 mg/kgFCTXAV 17,715,1979
oral/mouse lethal dose (50 percent kill): 1940 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
IYKEDH 15,359,1984
oral/rabbit lowest published lethal dose: 2 gm/kgHBTXAC 5,23,1959
oral/rat lethal dose (50 percent kill): 1700 mg/kgIPSTB3 3,93,1976
skin/human lowest published toxic dose: 6 mg/kgLung, Thorax, or Respiration: Dyspnea

Skin: After systemic exposure: Dermatitis, allergic
JOALAS 16,195,1945
subcutaneous/frog lowest published lethal dose: 100 mg/kgHBTXAC 5,23,1959
subcutaneous/rabbit lowest published lethal dose: 2 gm/kgHBTXAC 5,23,1959

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1200 mg/m3/4W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0539172

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHUTOX* -,259,1996
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWTXAPA9 243,225,2010

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,297,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 10210; Number of Industries 85; Total Number of Facilities 9179; Number of Occupations 81; Total Number of Employees Exposed 155176; Total Number of Female Employees Exposed 55139
National Occupational Hazard Survey 1974Hazard Code 10210; Number of Industries 35; Total Number of Facilities 2798; Number of Occupations 52; Total Number of Employees Exposed 77830

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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