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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzoic acid, 3,6-dichloro-2-methoxy-

RTECS #

DG7525000

CAS #

1918-00-9

Updated

October 2011

Molecular Weight

221.04

Molecular Formula

C8H6Cl2O3

Synonyms

2,5-Dichloro-6-methoxybenzoic acid
2-Methoxy-3,6-dichlorobenzoic acid
3,6-Dichloor-2-methoxy-benzoeizuur (Dutch)
3,6-Dichlor-3-methoxy-benzoesaeure (German)
3,6-Dichloro-2-methoxybenzoic acid
3,6-Dichloro-o-anisic acid
Acido (3,6-dicloro-2-metossi)-benzoico (Italian)
Banlen
Banvel 480
Banvel 4WS
Banvel CST
Banvel herbicide
Banvel II herbicide
Brush buster
Compound B dicamba
Dianat (Russian)
Dicamba
Dicamba technical
Kyselina 3,6-dichlor-2-methoxybenzoova (Czech)
MDBA
Mediben
o-Anisic acid, 3,6-dichloro-
Velsicol 58-CS-11
Velsicol compound R

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisunreported route/mouse500 mg/kgTGANAK 16(1),45,1982
DNA Damageovary/hamster50 mg/L/90MMUREAV 634,60,2007
DNA Damageintraperitoneal/rat17800 µg/kgEMMUEG 15,131,1990
DNA repair/Escherichia coli5 mg/discNTIS** PB80-133226
DNA repair/Bacillus subtilis5 mg/discNTIS** PB80-133226
sister chromatid exchangeovary/hamster1 mg/L/90MMUREAV 634,60,2007
Unscheduled DNA Synthesislymphocyte/rat200 mg/LEMMUEG 15,131,1990

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mammal (species unspecified) 136 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FEREAC 64,761,1999
oral/rat 28250 mg/kg (multigeneration)Reproductive: Other effects on male

Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HPV198 -,-,2001
oral/rat 5600 mg/kg (6-19D pregnant)Reproductive: Other effects on femaleHPV198 -,-,2001
oral/rabbit 650 mg/kg (6-18D pregnant)Reproductive: Other effects on femaleHPV198 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 5.3 gm/m3/4HFEREAC 64,760,1999
inhalation/rat lethal concentration (50 percent kill): >8200 mg/m3/4HBehavioral: Somnolence (general depressed activity)HPV198 -,-,2001
oral/guinea pig lethal dose (50 percent kill): 3 gm/kgHYSAAV 35(7-9),14,1970
oral/mouse lethal dose (50 percent kill): 1190 mg/kgENTOX* -,2,2005
oral/rabbit lethal dose (50 percent kill): 2000 mg/kgENTOX* -,2,2005
oral/rat lethal dose (50 percent kill): 1039 mg/kgFAATDF 7,299,1986
oral/wild bird lethal dose (50 percent kill): >2 gm/kgENTOX* -,2,2005
skin/rabbit lethal dose (50 percent kill): >1716 mg/kgHPV198 -,-,2001
skin/rat lethal dose (50 percent kill): >1 gm/kgWRPCA2 9,119,1970
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1 gm/kg30ZDA9 -,147,1971
unreported route/mouse lethal dose (50 percent kill): 700 mg/kgTGANAK 16(1),45,1982
unreported route/rat lowest published toxic dose: 300 mg/kgBehavioral: Ataxia

Behavioral: Alteration of classical conditioning
FEREAC 64,761,1999

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 1365 mg/kg/26W- intermittentLiver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 35(10),14,1970
oral/rat lowest published toxic dose: 110397 mg/kg/21W- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV198 -,-,2001
oral/rat lowest published toxic dose: 13244 mg/kg/43W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 47(10),77,1982
oral/rat lowest published toxic dose: 5600 mg/kg/14D- intermittentBehavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV198 -,-,2001
skin/rabbit lowest published toxic dose: 37500 mg/kg/3W- intermittentBehavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV198 -,-,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWJTCTDW 38,111,2000
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWENTOX* -,569,2005
TOXICOLOGY REVIEWENTOX* -,2,2005
TOXICOLOGY REVIEWFEREAC 73,17914,2008
TOXICOLOGY REVIEWFEREAC 73,31788,2008
TOXICOLOGY REVIEWFEREAC 73,54954,2008
TOXICOLOGY REVIEWREPTED 31,392,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,110,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code M4903; Number of Industries 1; Total Number of Facilities 17; Number of Occupations 1; Total Number of Employees Exposed 34

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; E coli polA without S9
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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