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Benzoic acid, 3,6 - dichloro - 2 - methoxy -

RTECS #: DG7525000

CAS #: 1918-00-9


UPDATE: February 2009 MW: 221.04 MF: C8H6Cl2O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2,5 - Dichloro - 6 - methoxybenzoic acid
  2. 2 - Methoxy - 3,6 - dichlorobenzoic acid
  3. 3,6 - Dichloor - 2 - methoxy - benzoeizuur (Dutch)
  4. 3,6 - Dichlor - 3 - methoxy - benzoesaeure (German)
  5. 3,6 - Dichloro - 2 - methoxybenzoic acid
  6. 3,6 - Dichloro - o - anisic acid
  7. Acido (3,6 - dicloro - 2 - metossi) - benzoico (Italian)
  8. Banlen
  9. Banvel 480
  10. Banvel 4WS
  11. Banvel CST
  12. Banvel II herbicide
  1. Banvel herbicide
  2. Brush buster
  3. Compound B dicamba
  4. Dianat (Russian)
  5. Dicamba
  6. Dicamba technical
  7. Kyselina 3,6 - dichlor - 2 - methoxybenzoova (Czech)
  8. MDBA
  9. Mediben
  10. Velsicol 58 - CS - 11
  11. Velsicol compound R
  12. o - Anisic acid, 3,6 - dichloro -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis unreported route
mouse
500 mg/kg TGANAK 16(1),45,1982
DNA damage hamster ovary 50 mg/L/90 minute MUREAV 634,60,2007
DNA damage intraperitoneal
rat
17,800 g/kg EMMUEG 15,131,1990
DNA repair Bacillus subtilis 5 mg/disc NTIS** PB80-133226
DNA repair Escherichia coli 5 mg/disc NTIS** PB80-133226
unscheduled DNA synthesis rat lymphocyte 200 mg/L EMMUEG 15,131,1990
sister chromatid exchange hamster ovary 1 mg/L/90 minute MUREAV 634,60,2007


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mammal (species unspecified)
lowest published toxic dose: 136 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FEREAC 64,761,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 5.3 gm/m3/4 hour N/R FEREAC 64,760,1999
oral
wild bird
lethal dose (50 percent kill): >2 gm/kg N/R ENTOX* -,2,2005
oral
guinea pig
lethal dose (50 percent kill): 3 gm/kg N/R HYSAAV 35(7-9),14,1970
oral
mouse
lethal dose (50 percent kill): 1,190 mg/kg N/R ENTOX* -,2,2005
oral
rat
lethal dose (50 percent kill): 1,039 mg/kg N/R FAATDF 7,299,1986
oral
rabbit
lethal dose (50 percent kill): 2,000 mg/kg N/R ENTOX* -,2,2005
skin
rat
lethal dose (50 percent kill): >1 gm/kg N/R WRPCA2 9,119,1970
skin
rabbit
lethal dose (50 percent kill): >2 gm/kg N/R ENTOX* -,2,2005
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 1 gm/kg N/R 30ZDA9 -,147,1971
unreported route
mouse
lethal dose (50 percent kill): 700 mg/kg N/R TGANAK 16(1),45,1982
unreported route
rat
lowest published toxic dose: 300 mg/kg Behavioral: Ataxia

Behavioral: Alteration of classical conditioning
FEREAC 64,761,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 13,244 mg/kg/43 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 47(10),77,1982
oral
rabbit
lowest published toxic dose: 1,365 mg/kg/26 week- intermittent Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 35(10),14,1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
JTCTDW 38,111,2000
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
ENTOX* -,569,2005
TOXICOLOGY REVIEW
ENTOX* -,2,2005
TOXICOLOGY REVIEW
FEREAC 73,17914,2008
TOXICOLOGY REVIEW
FEREAC 73,31788,2008
TOXICOLOGY REVIEW
FEREAC 73,17914,2008
TOXICOLOGY REVIEW
FEREAC 73,31788,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,110,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4903;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 1;
Total Number of Employees Exposed 34


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used to control annual and perennial broadleaf weeds in corn, grain sorghum, etc.
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used to control annual and perennial broadleaf weeds in corn, grain sorghum, etc.

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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