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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzofuran

RTECS #

DF6423800

CAS #

271-89-6

Updated

July 2012

Molecular Weight

118.14

Molecular Formula

C8H6O

Synonyms

1-Oxindene
2,3-Benzofuran
Benzo(b)furan
Benzofuran (IUPAC)
Benzofurfuran
Coumarone
Cumarone
NCI-C56166

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagekidney/rat0.125 mmol/L/20HTXCYAC 204,187,2004
DNA Damagekidney/human0.125 mmol/L/20HTXCYAC 204,187,2004
DNA Damageoral/rat500 mg/kgTXCYAC 204,187,2004
micronucleus testkidney/rat0.125 mmol/L/48HTXCYAC 204,187,2004
micronucleus testkidney/human0.125 mmol/L/48HTXCYAC 204,187,2004
micronucleus testoral/rat500 mg/kgTXCYAC 204,187,2004
mutation in mammalian somatic cellslymphocyte/mouse100 mg/LEMMUEG 11,91,1988
other mutation test systemsoral/mouse100 mg/kgMUREAV 343,157,1995
sister chromatid exchangeovary/hamster199 mg/LNTPTR* NTP-TR-370,1989
specific locus testother cell types/mouse1270 µmol/LMUREAV 608,29,2006

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 30900 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
NTPTR* NTP-TR-370,1989
oral/mouse lowest published toxic dose: 30900 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
NTIS** PB90-231127/AS
oral/mouse lowest published toxic dose: 61800 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
NTIS** PB90-231127/AS
oral/rat lowest published toxic dose: 30900 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB90-231127/AS
oral/rat lowest published toxic dose: 61800 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-370,1989

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 500 mg/kgEJMCA5 12,383,1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 32500 mg/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-370,1989
oral/mouse lowest published toxic dose: 437 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-370,1989
oral/rat lowest published toxic dose: 7 gm/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-370,1989
oral/rat lowest published toxic dose: 16250 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
NTPTR* NTP-TR-370,1989

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 63,431,1995
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 63,431,1995
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 63,431,1995
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 672,10,2009
TOXICOLOGY REVIEWMUREAV 672,17,2009
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWMUREAV 721,27,2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code M3271; Number of Industries 2; Total Number of Facilities 40; Number of Occupations 2; Total Number of Employees Exposed 111

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110666/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-370,1989
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