CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Benzofuran

RTECS #: DF6423800

CAS #: 271-89-6


UPDATE: May 2009 MW: 118.14 MF: C8H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Oxindene
  2. 2,3 - Benzofuran
  3. Benzo (b) furan
  4. Benzofuran (IUPAC)
  1. Benzofurfuran
  2. Coumarone
  3. Cumarone
  4. NCI - C56166


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human kidney 0.125 mmol/L/20 hour TXCYAC 204,187,2004
DNA damage rat kidney 0.125 mmol/L/20 hour TXCYAC 204,187,2004
DNA damage oral
rat
500 mg/kg TXCYAC 204,187,2004
micronucleus test human kidney 0.125 mmol/L/48 hour TXCYAC 204,187,2004
micronucleus test rat kidney 0.125 mmol/L/48 hour TXCYAC 204,187,2004
micronucleus test oral
rat
500 mg/kg TXCYAC 204,187,2004
mutation in mammalian somatic cells mouse lymphocyte 100 mg/L EMMUEG 11,91,1988
other mutation test systems oral
mouse
100 mg/kg MUREAV 343,157,1995
sister chromatid exchange hamster ovary 199 mg/L NTPTR* NTP-TR-370,1989
specific locus test mouse other cell types 1,270 Ámol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 30,900 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
NTPTR* NTP-TR-370,1989
oral
mouse
lowest published toxic dose: 30,900 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
NTIS** PB90-231127/AS
oral
mouse
lowest published toxic dose: 61,800 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
NTIS** PB90-231127/AS
oral
rat
lowest published toxic dose: 61,800 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-370,1989
oral
rat
lowest published toxic dose: 30,900 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB90-231127/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 500 mg/kg N/R EJMCA5 12,383,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-370,1989
oral
mouse
lowest published toxic dose: 437 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-370,1989
oral
rat
lowest published toxic dose: 7 gm/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-370,1989
oral
rat
lowest published toxic dose: 16,250 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
NTPTR* NTP-TR-370,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 63,431,1995
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 63,431,1995
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 63,431,1995
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
MUREAV 672,17,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3271;
Number of Industries 2;
Total Number of Facilities 40;
Number of Occupations 2;
Total Number of Employees Exposed 111


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110666/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate, in manufacture of plastics, resins, rubber
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-370,1989
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat


REFERENCES:

CODEN
REFERENCE

EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a chemical intermediate, in manufacture of plastics, resins, rubber

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us