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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzo(k)fluoranthene

RTECS #

DF6350000

CAS #

207-08-9

Updated

July 2011

Molecular Weight

252.32

Molecular Formula

C20H12

Synonyms

11,12-Benzo(k)fluoranthene
11,12-Benzofluoranthene
2,3,1',8'-Binaphthylene
8,9-Benzofluoranthene
Dibenzo(b,jk)fluorene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageoral/other fish125 µmol/kg/5D- intermittentMUREAV 427,135,1999
DNA Damage/Escherichia coli129.9 µg/L/3H (+enzymatic activation step)MUREAV 515,85,2002
DNA Damagefibroblast/human1 µmol/L/24HMUREAV 547,109,2004
micronucleus testliver/human50 µmol/L/24HTXCYAC 198,315,2004
mutation in mammalian somatic cellslymphocyte/human120 µg/LMUREAV 371,123,1996
mutation in microorganisms/Salmonella typhimurium0.5 nmol/plate/48H (-enzymatic activation step)MUREAV 557,99,2004
mutation in microorganisms/Salmonella typhimurium68 nmol/plate/48H (+enzymatic activation step)MUREAV 557,99,2004
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)CNREA8 40,4528,1980

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 5 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
50NNAZ 7,571,1983
skin/mouse lowest published toxic dose: 2820 mg/kg/47W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
CANCAR 12,1194,1959
subcutaneous/mouse lowest published toxic dose: 72 mg/kg/9W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
AICCA6 19,490,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 7570 µg/kgLiver: Changes in liver weight

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,396,2004
oral/mouse lowest published toxic dose: 15139 µg/kgLiver: Changes in liver weight

Blood: Changes in spleen

Immunological Including Allergic: Decrease in humoral immune response
JTEHF8 68,2033,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 52987 µg/kg/7D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in humoral immune response
TOXID9 78,396,2004
oral/mouse lowest published toxic dose: 52987 µg/kg/7D- intermittentLiver: Changes in liver weight

Immunological Including Allergic: Decrease in humoral immune response
JTEHF8 68,2033,2005
subcutaneous/rat lowest published toxic dose: 30 mg/kg/3D- intermittentLiver: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOLED5 180,212,2008

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 32,163,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 32,163,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 540,89,2003
TOXICOLOGY REVIEWMUREAV 558,155,2004
TOXICOLOGY REVIEWMUREAV 544,397,2003
TOXICOLOGY REVIEWTOLED5 140-141,353,2003
TOXICOLOGY REVIEWMUREAV 613,103,2006
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWMUREAV 636,144,2007
TOXICOLOGY REVIEWMUREAV 636,4,2007
TOXICOLOGY REVIEWMUREAV 727,1,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-NORWAYtime-weighted average 0.04 mg/m3, JAN1999

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code E0464; Number of Industries 3; Total Number of Facilities 142; Number of Occupations 3; Total Number of Employees Exposed 2283

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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