CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Benzo (k) fluoranthene

RTECS #: DF6350000

CAS #: 207-08-9


UPDATE: August 2008 MW: 252.32 MF: C20H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 11,12 - Benzofluoranthene
  2. 11,12 - Benzo (k) fluoranthene
  3. 2,3,1',8' - Binaphthylene
  1. 8,9 - Benzofluoranthene
  2. Dibenzo (b,jk) fluorene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage Escherichia coli 129.9 g/L/3 hour (+enzymatic activation step) MUREAV 515,85,2002
DNA damage human fibroblast 1 mol/L/24 hour MUREAV 547,109,2004
DNA damage oral
other fish
125 mol/kg/5 day- intermittent MUREAV 427,135,1999
mutation in microorganisms Salmonella typhimurium 10 g/plate (-enzymatic activation step) CNREA8 40,4528,1980
mutation in microorganisms Salmonella typhimurium 0.5 nmol/plate/48 hour (-enzymatic activation step) MUREAV 557,99,2004
mutation in microorganisms Salmonella typhimurium 68 nmol/plate/48 hour (+enzymatic activation step) MUREAV 557,99,2004
micronucleus test human liver 50 mol/L/24 hour TXCYAC 198,315,2004
mutation in mammalian somatic cells human lymphocyte 120 g/L MUREAV 371,123,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
implant
rat
lowest published toxic dose: 5 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
50NNAZ 7,571,1983
subcutaneous
mouse
lowest published toxic dose: 72 mg/kg/9 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
AICCA6 19,490,1963
skin
mouse
lowest published toxic dose: 2,820 mg/kg/47 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
CANCAR 12,1194,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 7,570 g/kg Liver: Changes in liver weight

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,396,2004
oral
mouse
lowest published toxic dose: 15,139 g/kg Liver: Changes in liver weight

Blood: Changes in spleen

Immunological Including Allergic: Decrease in humoral immune response
JTEHF8 68,2033,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 52,987 g/kg/7 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in humoral immune response
TOXID9 78,396,2004
oral
mouse
lowest published toxic dose: 52,987 g/kg/7 day- intermittent Liver: Changes in liver weight

Immunological Including Allergic: Decrease in humoral immune response
JTEHF8 68,2033,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 32,163,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 32,163,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 540,89,2003
TOXICOLOGY REVIEW
MUREAV 558,155,2004
TOXICOLOGY REVIEW
MUREAV 544,397,2003
TOXICOLOGY REVIEW
TOLED5 140-141,353,2003
TOXICOLOGY REVIEW
MUREAV 613,103,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - NORWAY time-weighted average 0.04 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: E0464;
Number of Industries 3;
Total Number of Facilities 142;
Number of Occupations 3;
Total Number of Employees Exposed 2,283


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

50NNAZ "Polynuclear Aromatic Hydrocarbons, International Symposium, 7th, 1982," Cooke, M., and A.J. Dennis, eds., Columbus, OH, Battelle Press, 1983
AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium) V.1-20, 1936-64. For publisher information, see IJCNAW.
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us