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Benzine (motor fuel)

RTECS #: DE3550000

CAS #: 86290-81-5


UPDATE: May 2008 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. A 76 (fuel)
  2. Ai 93 (fuel)
  3. Akvazin
  4. Automotive gasoline
  5. Benzine BR - 1
  6. Benzine BR - 2
  7. Benzyna (Polish)
  8. Fuels, gasoline
  9. Gasoline BR - 1
  1. Gasoline, synthetic
  2. Herbicide ES
  3. Indolene
  4. Natural gas condensates, gasoline
  5. Nefras 150/200
  6. Nefras S 50/170
  7. Petrol, synthetic
  8. Synfuels
  9. Synthetic gasoline


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
unscheduled DNA synthesis oral
mammal (species unspecified)
100 mg/kg VCVPS* ,52,1998
sperm morphology inhalation
rat
300 mg/m3/10 week- intermittent GTPZAB 16(8),25,1972


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 300 mg/m3 (1-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical
VCVPS* -,51,1998


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lethal dose (50 percent kill): 60 mL/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
GTPZAB 25(11),52,1981
oral
rat
lethal dose (50 percent kill): 92 gm/kg N/R GISAAA 32(3),31,1967
oral
rat
lethal dose (50 percent kill): 13.6 gm/kg Behavioral: Headache

Lung, Thorax, or Respiration: Cough

Eye: Conjunctiva irritation
VCVPS* -,49,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 12,000 mg/m3/83 week- intermittent Immunological Including Allergic: Uncharacterized (multiple organ involvement) VCVPS* -,52,1998
inhalation
dog
lowest published toxic concentration: 8,000 mg/m3/26 week- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath VCVPS* -,52,1998
inhalation
mouse
lowest published toxic concentration: 950 mg/m3/17 week- intermittent Autonomic Nervous System: Sympathomimetic

Autonomic Nervous System: Other (direct) parasympathomimetic

Blood: Changes in leukocyte (WBC) count
VCVPS* -,52,1998
inhalation
rat
lowest published toxic concentration: 100 mg/m3/4 hour/17 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GTPZAB 28(3),34,1984
inhalation
rat
lowest published toxic concentration: 5,283 g/m3/24 hour/15 week- continuous Behavioral: Muscle contraction or spasticity

Liver: Other changes

Endocrine: Other changes
GISAAA 31(3),3,1966
inhalation
rat
lowest published toxic concentration: 950 mg/m3/17 week- intermittent Autonomic Nervous System: Sympathomimetic

Autonomic Nervous System: Other (direct) parasympathomimetic

Blood: Changes in leukocyte (WBC) count
VCVPS* -,52,1998
inhalation
rat
lowest published toxic concentration: 900 mg/m3/6 week- continuous Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
VCVPS* -,52,1998
inhalation
rabbit
lowest published toxic concentration: 6 gm/m3/4 hour/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
BCTKAG 7,151,1974
inhalation
rabbit
lowest published toxic concentration: 950 mg/m3/17 week- intermittent Autonomic Nervous System: Sympathomimetic

Autonomic Nervous System: Other (direct) parasympathomimetic

Blood: Changes in leukocyte (WBC) count
VCVPS* -,52,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 300 ppm;short term exposure limit 500 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 240 mg/m3, 2003
Occupational Exposure Limit - SWEDEN time-weighted average 250 mg/m3, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264206/AS)
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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