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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzine (motor fuel)

RTECS #

DE3550000

CAS #

86290-81-5

Updated

September 201

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

A 76 (fuel)
Ai 93 (fuel)
Akvazin
Automotive gasoline
Benzine BR-1
Benzine BR-2
Benzyna (Polish)
Fuels, gasoline
Gasoline BR-1
Gasoline, synthetic
Herbicide ES
Indolene
Natural gas condensates, gasoline
Nefras 150/200
Nefras S 50/170
Petrol, synthetic
Synfuels
Synthetic gasoline

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sperm morphologyinhalation/rat300 mg/m3/10W- intermittentGTPZAB 16(8),25,1972
Unscheduled DNA Synthesisoral/mammal (species unspecified)100 mg/kgVCVPS* ,52,1998

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 300 mg/m3 (1-19D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical
VCVPS* -,51,1998

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 60 mL/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
GTPZAB 25(11),52,1981
oral/rat lethal dose (50 percent kill): 13.6 gm/kgBehavioral: Headache

Lung, Thorax, or Respiration: Cough

Eye: Conjunctiva irritation
VCVPS* -,49,1998
oral/rat lethal dose (50 percent kill): 92 gm/kgGISAAA 32(3),31,1967

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 12000 mg/m3/83W- intermittentImmunological Including Allergic: Uncharacterized (multiple organ involvement)VCVPS* -,52,1998
inhalation/Dog lowest published toxic concentration: 8000 mg/m3/26W- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheathVCVPS* -,52,1998
inhalation/mouse lowest published toxic concentration: 950 mg/m3/17W- intermittentAutonomic Nervous System: Sympathomimetic

Autonomic Nervous System: Other (direct) parasympathomimetic

Blood: Changes in leukocyte (WBC) count
VCVPS* -,52,1998
inhalation/rabbit lowest published toxic concentration: 6 gm/m3/4H/26W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
BCTKAG 7,151,1974
inhalation/rabbit lowest published toxic concentration: 950 mg/m3/17W- intermittentAutonomic Nervous System: Sympathomimetic

Autonomic Nervous System: Other (direct) parasympathomimetic

Blood: Changes in leukocyte (WBC) count
VCVPS* -,52,1998
inhalation/rat lowest published toxic concentration: 950 mg/m3/17W- intermittentAutonomic Nervous System: Sympathomimetic

Autonomic Nervous System: Other (direct) parasympathomimetic

Blood: Changes in leukocyte (WBC) count
VCVPS* -,52,1998
inhalation/rat lowest published toxic concentration: 100 mg/m3/4H/17W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GTPZAB 28(3),34,1984
inhalation/rat lowest published toxic concentration: 5283 µg/m3/24H/15W- continuousBehavioral: Muscle contraction or spasticity

Liver: Other changes

Endocrine: Other changes
GISAAA 31(3),3,1966
inhalation/rat lowest published toxic concentration: 900 mg/m3/6W- continuousOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
VCVPS* -,52,1998

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 300 ppm;short term exposure limit 500 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-SWEDENtime-weighted average 250 mg/m3, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 240 mg/m3, 2003

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264206/AS)
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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