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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, 1,1'-oxybis-, pentabromo deriv.

RTECS #

DD6625350

CAS #

32534-81-9; 132405-96-0; 134206-43-2

Updated

August 2009

Molecular Weight

564.72

Molecular Formula

C12H5Br5O

Synonyms

Bromkal G1
DE60FTM
Pentabromodiphenyl ether
Pentabromodiphenyl ether (DE-71)
Pentabromodiphenyl oxide
Planelon PB 501
Saytex 125

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 µL/24H mildNTIS** OTS0522196
skin /rabbit 100 µL/24H moderateNTIS** OTS0522196

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >200 gm/m3/1HEye: Lacrimation

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0540414
inhalation/rat lethal concentration (50 percent kill): 200 gm/m3/1HBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
oral/mouse lowest published toxic dose: 0.8 mg/kgEndocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 86,49,1994
oral/rat lethal dose (50 percent kill): 7.4 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
oral/rat lethal dose (50 percent kill): 5 gm/kgBehavioral: Tremor

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0522287
skin/rabbit Lethal dose: >2 gm/kgNTIS** OTS0540414
skin/rabbit lethal dose (50 percent kill): 2 gm/kg/24HBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
skin/rat lowest published lethal dose: 5500 mg/kgBehavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair
NTIS** OTS0522196

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mammal (species unspecified) lowest published toxic dose: 790.6 mg/kg/2W- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
VCVGK* -,315,1994
oral/mouse lowest published toxic dose: 14000 mg/kg/14D- intermittentEndocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 86,49,1994
oral/rat lowest published toxic dose: 39040 mg/kg/122D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,315,1994
oral/rat lowest published toxic dose: 280 mg/kg/28D- continuousLiver: Other changes

Liver: Changes in liver weight
EVHPAZ 109,49,2001
oral/rat lowest published toxic dose: 420 mg/kg/14D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 90,160,2006
oral/rat lowest published toxic dose: 478.8 mg/kg/28D- intermittentLiver: Changes in liver weightTOLED5 180S,S52,2008
oral/rat lowest published toxic dose: 19.6 mg/kg/28D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOLED5 180S,S52,2008
oral/rat lowest published toxic dose: 14 mg/kg/28D- intermittentLiver: Other changesTOLED5 180S,S52,2008

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 127,111,2002
TOXICOLOGY REVIEWENTOX* -,507,2005
TOXICOLOGY REVIEWJTEHF8 69,21,2006

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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