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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Benzimidazolecarbamic acid, methyl ester

RTECS #

DD6500000

CAS #

10605-21-7; 63090-40-4; 63278-70-6; 105268-95-9

Updated

December 2013

Molecular Weight

191.21

Molecular Formula

C9H9N3O2

Synonyms

1H-Benzimidazol-2-ylcarbamic acid methyl ester
2-(Carbomethoxyamino)benzimidazole
2-(Methoxy-carbonylamino)-benzimidazol (German)
2-(Methoxycarbonylamino)-benzimidazole
A 118
A 118 (pesticide)
Agrizim
Antibac MF
BA 67054F
BAS 3460 F
BAS-3460
Battal
Bavistan
Bavistin
Bavistin 3460
BCM (fungicide)
Bengard
Benzimidazole carbamate de methyle (French)
Benzimidazole-2-carbamic acid, methyl ester
Bercema-Bitosen
Bitosen
BMK
BMK (fungicide)
CARB
Carben VL
Carbendazim
Carbendazime
Carbendazol
Carbendazole
Carbendazym
CTR 6669
Custos
Delsene
Derosal
EK 578
Equitdazin
Falicarben
FB 642
Funaben
Funaben 3
Funaben 50
G 665
Garbenda
HOE 17411
IPO-1250
Kemdazin
Kolfugo
Kolfugo Extra
Lignasan
MBC
Mecarzole
Medamine
Methyl 1H-benzemedazol-2-ylcarbamate
Methyl 2-benzimidazolecarbamate
Methyl benzimidazol-2-yl carbamate
Myco
Pillarstin
Preparation G 665
Preventol BCM
Spin
Stein
Stempor
Supercarb
Thicoper
Triticol
U-32.104

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisliver/human100 µmol/LMUREAV 26,177,1974
Cytogenetic AnalysisHeLa cell/human100 µmol/LMUREAV 26,177,1974
Cytogenetic Analysisoral/rat1 gm/kgMUREAV 26,177,1974
Cytogenetic Analysisoral/hamster100 mg/kgTRENAF 36,396,1985
Cytogenetic Analysislung/hamster100 µmol/LMUREAV 26,177,1974
Cytogenetic Analysisother cell types/mouse2.5 mg/L/24HMUREAV 577S,1,2005
Cytogenetic Analysisoral/mouse125 mg/kgEMS37* -,437,2006
Cytogenetic Analysisovary/hamster50000 µg/L/4H (+enzymatic activation step)HPV162 -,-,2005
Cytogenetic Analysisovary/non-mammalian species1 µmol/L/3HMUTAEX 14,375,1999
DNA Damageoral/rat6000 mg/kg/3D- intermittentMUREAV 722,7,2011
DNA inhibitionoral/mouse375 mg/kgFCTOD7 28,701,1990
gene conversion and mitotic recombination/Saccharomyes cerevisiae150 mg/LIJEBA6 16,393,1978
micronucleus testlymphocyte/human1 µmol/LMUREAV 156,199,1985
micronucleus testoral/mouse200 mg/kg/24HMUREAV 40,339,1976
micronucleus testother cell types/mouse10 mg/LJNCIAM 56,357,1976
micronucleus testintraperitoneal/mouse500 mg/kgMUREAV 300,15,1993
micronucleus testoral/mouse750 mg/kg/6DMUREAV 632,89,2007
micronucleus testoral/hamster2 gm/kg/24HMUREAV 40,339,1976
micronucleus testlung/hamster316 µg/LMUREAV 468,137,2000
micronucleus testoral/rat150 mg/kgMUREAV 478,211,2001
micronucleus testoral/rat300 mg/kg/2DMUREAV 478,211,2001
micronucleus testother cell types/hamster10000 ppm/3H (-enzymatic activation step)FCTOD7 39,843,2001
micronucleus testoral/mouse500 mg/kgMUTAEX 16,39,2001
micronucleus testoral/rat3000 mg/kg/3D- intermittentMUREAV 722,7,2011
micronucleus testovary/hamster13.3 µmol/L/24H (-enzymatic activation step)MUREAV 751,1,2013
micronucleus testovary/hamster120 µmol/L/3H (+enzymatic activation step)MUREAV 751,1,2013
micronucleus testovary/hamster1.81 µmol/L/24HMUTAEX 28,417,2013
micronucleus testlymphocyte/human7.5 mg/L/48HMUTAEX 24,85,2009
micronucleus testother cell types/mouse0.008 µmol/l/24HMUTAEX 22,275,2007
mutation in microorganisms/Aspergillus nidulans580 nmol/L (-enzymatic activation step)MUREAV 88,45,1981
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)MUREAV 15,273,1972
mutation in microorganisms/Salmonella typhimurium333 µg/plate (-enzymatic activation step)ENMUDM 9(Suppl 9),1,1987
mutation in microorganisms/Other microorganisms580 nmol/L (-enzymatic activation step)MUREAV 88,45,1981
other mutation test systems/Other microorganisms10 mg/LNNGADV 9,497,1984
other mutation test systemsleukocyte/human1 mg/LTHERAP 31,505,1976
other mutation test systemslymphocyte/human20 mg/LMUREAV 204,627,1988
sex chromosome loss and nondisjunction/Aspergillus nidulans280 µg/LEVHPAZ 31,81,1979
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae25 ppmANYAA9 407,186,1983
sex chromosome loss and nondisjunctionoral/mouse500 mg/kgMUREAV 300,15,1993
sex chromosome loss and nondisjunctionoral/hamster1 gm/kgCHROAU 97,224,1988
sex chromosome loss and nondisjunctionovary/hamster25 µmol/LMUREAV 419,79,1998
sex chromosome loss and nondisjunctionlymphocyte/human1389 µg/LMUREAV 464,41,2000
sister chromatid exchangelymphocyte/human10 mg/LNULSAK 26,9,1983
specific locus testoral/mouse200 mg/kgCBINA8 26,115,1979
specific locus testother cell types/mouse2 mg/L/24HMUTAEX 20,469,2005
specific locus testother cell types/mouse0.01 µmol/l/24HMUTAEX 22,275,2007
specific locus testother cell types/mouse13 µmol/l/24H (-enzymatic activation step)MUTAEX 26,771,2011
sperm morphologyoral/rat150 mg/kgANDRDQ 6,245,1974

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 1200 µg/m3/4H (72D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)GISAAA 48(7),83,1983
oral/rat 31200 µg/kg (13D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
KHZDAN 25,333,1982
oral/mouse 100 mg/kg (10D pregnant)Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)CBINA8 26,115,1979
oral/mouse 5 gm/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JTEHD6 20,387,1987
oral/rat 200 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
PLPBBH 37,331,1995
oral/mouse 5 gm/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JJATDK 18,241,1998
oral/hamster 250 mg/kg (1D prior to copulation)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)TXAPA9 114,225,1992
oral/hamster 500 mg/kg (1D prior to copulation)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TXAPA9 114,225,1992
oral/rat 32.4 gm/kg (83D male/79D prior to copulation)Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
FAATDF 15,281,1990
oral/rat 20.5 gm/kg (83D male/79D pre-1D after birth)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Other developmental abnormalities
FAATDF 15,281,1990
oral/rat 41 gm/kg (83D male/79D pre-1D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
FAATDF 15,281,1990
oral/hamster 57 gm/kg (60D male/46D pre-21D after birth)Reproductive: Specific developmental abnormalities: Urogenital systemFAATDF 15,281,1990
oral/rat 350 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TCMUD8 21,335,2001
oral/Dog 3663 mg/kg (90D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductFEREAC 67,55137,2002
oral/rat 50 mg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
FEREAC 67,55137,2002
oral/rat 5600 mg/kg (28D male/28D prior to copulation)Reproductive: Specific developmental abnormalities: Urogenital systemJTEHF8 67,1501,2004
oral/rat 395 gm/kg (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)HPV162 -,-,2005
oral/rat 200 mg/kg (7-16D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV162 -,-,2005
oral/rat 8000 mg/kg (80D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
TIHEEC 25,41,2009
oral/rat 4 gm/kg (10D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
BIREBV 37,709,1987
oral/rat 153 mg/kg (8-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system
THERAP 31,505,1976
oral/rat 150 mg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)ANDRDQ 6,245,1974
oral/rat 153 mg/kg (8-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
THERAP 31,505,1976
oral/rat 153 mg/kg (8-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
ARCVBP 21,87,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intradermal/rat lowest published toxic dose: 3824.2 mg/kgBlood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Lipids including transport
JTSCDR 33,25,2008
intradermal/rat lowest published toxic dose: 7648.4 mg/kgBlood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Lipids including transport
JTSCDR 33,25,2008
intradermal/rat lowest published toxic dose: 38242 mg/kgLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count
JTSCDR 33,25,2008
intraperitoneal/mouse lethal dose (50 percent kill): 1225 mg/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 52(3),58,1987
intraperitoneal/rat lethal dose (50 percent kill): 1720 mg/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 52(3),58,1987
oral/chicken lethal dose (50 percent kill): 1800 mg/kgINJPD2 18,102,1986
oral/Dog lethal dose (50 percent kill): >2500 mg/kgPEMNDP 9,123,1991
oral/guinea pig lethal dose (50 percent kill): 4150 mg/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 52(3),58,1987
oral/mouse lethal dose (50 percent kill): 7700 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 25(5),49,1981
oral/quail lethal dose (50 percent kill): >10 gm/kgPEMNDP 9,123,1991
oral/rabbit lethal dose (50 percent kill): 8160 mg/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 52(3),58,1987
oral/rat lethal dose (50 percent kill): >5050 mg/kgHPV162 -,-,2005
skin/rabbit lethal dose (50 percent kill): 8500 mg/kgINJPD2 18,102,1986
skin/rat lethal dose (50 percent kill): 2 gm/kg85DPAN -,-,1971/1976

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 3150 mg/kg/90D- intermittentLiver: Multiple effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FEREAC 67,55137,2002
oral/Dog lowest published toxic dose: 9125 mg/kg/2Y- intermittentLiver: Multiple effectsFEREAC 67,55137,2002
oral/hamster lowest published toxic dose: 24000 mg/kg/60D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
FAATDF 15,281,1990
oral/mouse lowest published toxic dose: 18000 mg/kg/3W- intermittentTumorigenic: Active as anti-cancer agentINNDDK 20,261,2002
oral/mouse lowest published toxic dose: 24000 mg/kg/3W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
INNDDK 20,261,2002
oral/mouse lowest published toxic dose: 12000 mg/kg/3W- intermittentTumorigenic: Active as anti-cancer agent

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
INNDDK 20,261,2002
oral/mouse lowest published toxic dose: 10500 mg/kg/21D- intermittentTumorigenic: Active as anti-cancer agentINNDDK 20,261,2002
oral/mouse lowest published toxic dose: 52500 mg/kg/21D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldINNDDK 20,261,2002
oral/rat lowest published toxic dose: 17 gm/kg/85D- intermittentEndocrine: Androgenic

Related to Chronic Data: Changes in testicular weight
TXAPA9 101,55,1989
oral/rat lowest published toxic dose: 1400 mg/kg/56D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductJTEHF8 67,1501,2004
oral/rat lowest published toxic dose: 18900 mg/kg/28D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
JTEHF8 67,1501,2004
oral/rat lowest published toxic dose: 8000 mg/kg/80D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
TIHEEC 25,41,2009
oral/rat lowest published toxic dose: 16000 mg/kg/80D- intermittentEndocrine: Change in LH

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in testicular weight
TIHEEC 25,41,2009
oral/rat lowest published toxic dose: 1440 mg/kg/90D- intermittentLung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
BECTA6 38,890,1987
oral/rat lowest published toxic dose: 91250 mg/kg/2Y- continuousLiver: Changes in liver weightBCTKAG 13,229,1980
oral/rat lowest published toxic dose: 8000 mg/kg/8D- intermittentEndocrine: Change in LH

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 15,528,1990
oral/rat lowest published toxic dose: 400 mg/kg/85D- intermittentEndocrine: Change in LH

Endocrine: Change in gonadotropins

Blood: Other changes
TXCYAC 57,173,1989
oral/rat lowest published toxic dose: 50 mg/kg/85D- intermittentBrain and Coverings: Other degenerative changesTXCYAC 57,173,1989
oral/rat lowest published toxic dose: 200 mg/kg/85D- intermittentReproductive: Effects on fertility: Other measures of fertilityTXCYAC 57,173,1989
oral/rat lowest published toxic dose: 16600 mg/kg/83D- intermittentEndocrine: Change in gonadotropins

Endocrine: Androgenic

Related to Chronic Data: Changes in testicular weight
FAATDF 15,281,1990
oral/rat lowest published toxic dose: 4150 mg/kg/83D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
FAATDF 15,281,1990

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWTOLED5 128,45,2002
TOXICOLOGY REVIEWTOLED5 140-141,53,2003
TOXICOLOGY REVIEWTOLED5 140-141,63,2003
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWMUTAEX 15,431,2000
TOXICOLOGY REVIEWEMMUEG 45,271,2005
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWMUTAEX 20,389,2005
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUTAEX 26,163,2011
TOXICOLOGY REVIEWMUTAEX 26,223,2011
TOXICOLOGY REVIEWMUTAEX 21,343,2006
TOXICOLOGY REVIEWMUTAEX 26,199,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 723,108,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,357,1998
Occupational Exposure Limit-GERMANYMAK 10 mg/m3, inhal, skin, sen, 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, KZG-week 40 mg/m3, inhal, JAN2011

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Aspergillus-recombination
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-aneuploidy; Mouse spot test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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