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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzilic acid, 4,4'-dichloro-, ethyl ester

RTECS #

DD2275000

CAS #

510-15-6

Updated

July 2012

Molecular Weight

325.20

Molecular Formula

C16H14Cl2O3

Synonyms

4,4'-Dichlorbenzilsaeureaethylester (German)
4,4'-Dichlorobenzilate
4,4'-Dichlorobenzilic acid ethyl ester
ACAR
Acaraben
Acaraben 4E
AKAR
AKAR 338
AKAR 50
Benzeneacetic acid, 4-chloro-alpha-(4-chlorophenyl)-alpha-hydroxy-, ethyl ester
Benzilan
Benz-O-chlor
Chlorbenzilat
Chlorbenzilate
Chlorbenzylate
Chlorobenzilate
Chlorobenzylate
Compound 338
ENT 18,596
Ethyl 4,4'-dichlorobenzilate
Ethyl 4,4'-dichlorodiphenyl glycollate
Ethyl 4,4'-dichlorophenyl glycollate
Ethyl 4-chloro-alpha-(4-chlorophenyl)-alpha-hydroxybenzeneacetate
Ethyl ester of 4,4'-dichlorobenzilic acid
Ethyl p,p'-dichlorobenzilate
Ethyl-2-hydroxy-2,2-bis(4-chlorophenyl)acetate
Ethylester kyseliny 4,4-dichlorbenzilove (Czech)
Folbex
Folbex smoke-strips
G 23992
G 338
Geigy 338
Kop-mite
NCI-C00408
NCI-C60413
RCRA waste number U038

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 25 mg moderateCIGET* -,-,1977
skin /rabbit 125 mg open irritation test mildCIGET* -,-,1977

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformoral/rat4620 mg/kg/77D-continuousCRNGDP 11,1413,1990
mutation in mammalian somatic cellslymphocyte/mouse80 mg/LEMMUEG 12,85,1988
mutation in microorganismslymphocyte/mouse70 mg/L (+enzymatic activation step)EMMUEG 12,85,1988
other mutation test systemsoral/mouse360 mg/kgMUREAV 343,157,1995
other mutation test systems/Escherichia coli12010 nmol/LEMMUEG 19,98,1992
specific locus testother cell types/mouse277 µmol/LMUREAV 608,29,2006

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 71 gm/kg/82W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease
JNCIAM 42,1101,1969
oral/mouse toxic dose: 210 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-75,1978
oral/mouse toxic dose: 125 gm/kg/83W- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
DIGEBW 16,308,1977
oral/rat toxic dose: 17520 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors
CTOXAO 16,67,1980
oral/rat toxic dose: 72 gm/kg/78W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-75,1978
oral/rat toxic dose: 1752 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Adrenal cortex tumors

Skin and Appendages: Tumors
CTOXAO 16,67,1980
oral/rat lowest published toxic dose: 5475 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors
CTOXAO 16,67,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/hamster lethal dose (50 percent kill): 700 mg/kgTXAPA9 48,A192,1979
oral/mouse lethal dose (50 percent kill): 700 mg/kgHBPTO* 2,1342,2001
oral/rat lethal dose (50 percent kill): 700 mg/kgHBPTO* 2,1342,2001
skin/rabbit lethal dose (50 percent kill): >1 gm/kgSPEADM 78-1,15,1978
skin/rat lethal dose (50 percent kill): >5 gm/kgTXAPA9 14,515,1969
unreported route/mouse lethal dose (50 percent kill): 729 mg/kg30ZDA9 -,141,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 4200 mg/kg/17W- intermittentImmunological Including Allergic: Decrease in cellular immune responseFATOAO 35(3),352,1972

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 30,73,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 30,73,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEW85CVA2 5,250,1970
TOXICOLOGY REVIEWCTOXAO 13,231,1978
TOXICOLOGY REVIEWENTOX* -,559,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,98,1998

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (feed);clear evidence:mouseNCITR* NCI-TR-75,1978
NCI Carcinogenesis Bioassay (feed);inadequate studies:ratNCITR* NCI-TR-75,1978
On EPA IRIS database
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