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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzhydrol, 4,4'-dichloro-alpha-(trichloromethyl)-

RTECS #

DC8400000

CAS #

115-32-2

Updated

December 2012

Molecular Weight

370.48

Molecular Formula

C14H9Cl5O

Synonyms

1,1,1-Trichlor-2,2-bis(4-chlorphenyl)-aethanol (German)
1,1-Bis(4-chlorophenyl)-2,2,2-trichloroethanol
1,1-Bis(chlorophenyl)-2,2,2-trichloroethanol
1,1-Bis(p-chlorophenyl)-2,2,2-trichloroethanol
2,2,2-Trichloor-1,1-bis(4-chloor fenyl)-ethanol (Dutch)
2,2,2-Trichlor-1,1-bis(4-chlor-phenyl)-aethanol (German)
2,2,2-Trichloro-1,1-bis(4-chlorophenyl)-ethanol (French)
2,2,2-Trichloro-1,1-bis(4-cloro-fenil)-etanolo (Italian)
2,2,2-Trichloro-1,1-di-(4-chlorophenyl)ethanol
4,4'-Dichloro-alpha-(trichloromethyl)benzhydrol
4-Chloro-alpha-(4-chlorophenyl)-alpha-(trichloromethyl)benzenemethanol
Acarin
Benzenemethanol, 4-chloro-alpha-(4-chlorophenyl)-alpha-(trichloromethyl)-
Carbax
Cekudifol
CPCA
Decofol
Di-(p-chlorophenyl)trichloromethylcarbinol
Dichlorokelthane
Dicofol
Dicofol technical grade
Dicomite
DTMC
ENT 23,648
Ethanol, 2,2,2-trichloro-1,1-bis(p-chlorophenyl)-
FW 293
Hifol
Hilfol 18.5 EC
Keltane
Kelthane
Kelthane A
Kelthane dust base
Kelthanethanol
Milbol
Mitigan
NCI-C00486
para,para'-Kelthane

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisleukocyte/human20 mg/LHOEKAN 29,33,1979
micronucleus testoral/mouse215 mg/kgCHYCDW 21,238,1987
morphological transformoral/rat4620 mg/kg/77D-continuousCRNGDP 11,1413,1990
sister chromatid exchangelymphocyte/human1 µmol/LARTODN 52,221,1983
specific locus testother cell types/mouse135 µmol/LMUREAV 608,29,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 430 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
CHYCDW 21,238,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 17 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-90,1978
oral/mouse toxic dose: 35 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-90,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >5 gm/m3/4HPEMNDP 9,267,1991
intraperitoneal/rat lethal dose (50 percent kill): 1150 mg/kgTXAPA9 15,30,1969
oral/chicken lethal dose (50 percent kill): 4365 mg/kgVETNAL 60(10),64,1984
oral/Dog lethal dose (50 percent kill): 4 gm/kgVTYMAC 74,1119,1979
oral/guinea pig lethal dose (50 percent kill): 1810 mg/kgVCVGK* -,191,1994
oral/mouse lethal dose (50 percent kill): 420 mg/kgVCVGK* -,191,1994
oral/rabbit lethal dose (50 percent kill): 1810 mg/kgBehavioral: Muscle contraction or spasticityTXAPA9 1,119,1959
oral/rabbit lethal dose (50 percent kill): 575 mg/kgHBPTO* 2,1342,2001
oral/rat lethal dose (50 percent kill): 575 mg/kgVCVGK* -,191,1994
oral/woman lowest published toxic dose: 800 µL/kgEye: Miosis (pupilliary constriction)

Behavioral: Excitement

Gastrointestinal: Hypermotility, diarrhea
YAKUD5 34,1232,1992
skin/rabbit lethal dose (50 percent kill): 1870 mg/kgVCVGK* -,191,1994
skin/rat lethal dose (50 percent kill): 100 mg/kgVCVGK* -,191,1994
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 433 mg/kgGISAAA 38(8),101,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 40 mg/kg/4D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOLED5 190,150,2009
oral/chicken lowest published toxic dose: 8368 mg/kg/20D- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired

Endocrine: Hyperglycemia
VETNAL 60(10),64,1984
oral/Dog lowest published toxic dose: 8212.5 mg/kg/1Y- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHBPTO* 2,1342,2001
oral/mouse lowest published toxic dose: 8190 mg/kg/13W- continuousCardiac: Changes in heart weight

Liver: Other changes

Liver: Changes in liver weight
ESKHA5 105,42,1987
oral/rat lowest published toxic dose: 4200 mg/kg/12W- continuousLiver: Other changes

Liver: Changes in liver weight

Endocrine: Changes in thyroid weight
TXCYAC 1,113,1973
oral/rat lowest published toxic dose: 2670 mg/kg/25D- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 39(10),102,1974
oral/rat lowest published toxic dose: 6000 mg/kg/30D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductBECTA6 69,741,2002
oral/rat lowest published toxic dose: 12000 mg/kg/30D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
BECTA6 69,741,2002
oral/rat lowest published toxic dose: 15000 mg/kg/30D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
BECTA6 69,741,2002

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 30,87,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 30,87,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEWTOLED5 128,45,2002
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWFEREAC 72,41913,2007
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWFCTOD7 47,2906,2009
TOXICOLOGY REVIEWREPTED 31,337,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWREPTED 33,269,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,112,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83793; Number of Industries 2; Total Number of Facilities 474; Number of Occupations 1; Total Number of Employees Exposed 3934; Total Number of Female Employees Exposed 365
National Occupational Hazard Survey 1974Hazard Code 83793; Number of Industries 3; Total Number of Facilities 646; Number of Occupations 2; Total Number of Employees Exposed 9769

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouseNCITR* NCI-TR-90,1978
NCI Carcinogenesis Bioassay (feed);no evidence:ratNCITR* NCI-TR-90,1978
On EPA IRIS database
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