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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, 1,3,5-trichloro-

RTECS #

DC2100100

CAS #

108-70-3

Updated

July 2013

Molecular Weight

181.44

Molecular Formula

C6H3Cl3

Synonyms

1,3,5-Trichlorobenzene
s-Trichlorobenzene
sym-Trichlorobenzene

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg mildNTIS** OTS0537049
skin /rabbit 500 mg/24H mildNTIS** OTS0537049

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Dominant Lethal Testparenteral/other insects10 ppmEVETBX 2,1029,1973
Dominant Lethal Testskin/other insects10 ppmEVETBX 2,1029,1973
micronucleus testintraperitoneal/mouse425 mg/kg/24HMUTAEX 2,111,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >9300 mg/m3/1HNTIS** OTS0537049
intraperitoneal/mouse lethal dose (50 percent kill): 2260 mg/kgMUTAEX 2,111,1987
oral/mouse lethal dose (50 percent kill): 3350 mg/kgNTIS** UCRL-13701
oral/rat lethal dose (50 percent kill): 800 mg/kg48RKAL -,389,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 7380 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight
DCTODJ 11,11,1988

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (37 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (38 mg/m3), short term exposure limit 10 ppm (75 mg/m3), NOV2011
Occupational Exposure Limit-GERMANYMAK 5 ppm (38 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (37 mg/m3), skin, NOV2011
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (38 mg/m3), skin, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code M2497; Number of Industries 3; Total Number of Facilities 60; Number of Occupations 8; Total Number of Employees Exposed 1673

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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