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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, 1,2,3-trichloro-

RTECS #

DC2095000

CAS #

87-61-6

Updated

July 2013

Molecular Weight

181.44

Molecular Formula

C6H3Cl3

Synonyms

1,2,3-Trichlorobenzene
1,2,6-Trichlorobenzene
vic-Trichlorobenzene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testintraperitoneal/mouse250 mg/kg/24HMUTAEX 2,111,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 6000 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleHPV173 -,-,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 1390 mg/kgMUTAEX 2,111,1987
oral/rat lethal dose (50 percent kill): 1830 mg/kgDCTODJ 11,11,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 7020 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 11,11,1988

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWREPTED 26,13,2008
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (37 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (38 mg/m3), short term exposure limit 10 ppm (75 mg/m3), NOV2011
Occupational Exposure Limit-GERMANYMAK 5 ppm (38 mg/m3), skin, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (37 mg/m3), skin, NOV2011
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (38 mg/m3), skin, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X9450; Number of Industries 1; Total Number of Facilities 38; Number of Occupations 2; Total Number of Employees Exposed 691

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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