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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, 1,2,4,5-tetrachloro-

RTECS #

DB9450000

CAS #

95-94-3

Updated

November 2003

Molecular Weight

215.88

Molecular Formula

C6H2Cl4

Synonyms

1,2,4,5-Tetrachlorbenzol (Russian)
1,2,4,5-Tetrachlorobenzene
Benzene tetrachloride
RCRA waste number U207
s-Tetrachlorobenzene

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse Lethal dose: >500 mg/kgCBCCT* 4,107,1952
intraperitoneal/rat lowest published toxic dose: 0.8 mg/kgKidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 111,69,1991
intraperitoneal/rat lowest published toxic dose: 0.5 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)TXAPA9 111,69,1991
oral/mouse lethal dose (50 percent kill): 1035 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
HYSAAV 30(1-3),8,1965
oral/rabbit lethal dose (50 percent kill): 1500 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness
GISAAA 30(1),9,1965
oral/rat lethal dose (50 percent kill): 1727 mg/kgBehavioral: Muscle weakness

Behavioral: Coma

Nutritional and Gross Metabolic: Body temperature decrease
VCVGK* -,28,1984
oral/rat lethal dose (50 percent kill): 1500 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
HYSAAV 30(1-3),8,1965

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2100 mg/kg/14D- continuousBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NIH-91-3126
oral/mouse lowest published toxic dose: 4550 mg/kg/13W- continuousLiver: Changes in liver weight

Blood: Microcytosis with or without anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
NTPTR* NIH-91-3126
oral/mouse lowest published toxic dose: 4.536 mg/kg/105D- continuousLiver: Changes in liver weightNTIS** PB92-128388
oral/mouse lowest published toxic dose: 4.725 mg/kg/105D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** PB92-128388
oral/rabbit lowest published toxic dose: 12 mg/kg/35W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in other cell count (unspecified)
GISAAA 30(1),9,1965
oral/rat lowest published toxic dose: 5600 mg/kg/28D- intermittentBehavioral: Muscle weakness

Behavioral: Coma

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,29,1994
oral/rat lowest published toxic dose: 5460 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Pigmented or nucleated red blood cells
NTIS** PB91-185330
oral/rat lowest published toxic dose: 896 mg/kg/28D- continuousLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
JTEHD6 11,663,1983
oral/rat lowest published toxic dose: 2700 mg/kg/90D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
DCTODJ 7,113,1984
oral/rat lowest published toxic dose: 4567 mg/kg/9W- intermittentEndocrine: Changes in adrenal weight

Blood: Changes in bone marrow not included in above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 30(1),9,1965
oral/rat lowest published toxic dose: 12 mg/kg/35W- intermittentBehavioral: Alteration of classical conditioning

Liver: Changes in liver weight
GISAAA 30(1),9,1965
unreported route/rat lowest published toxic dose: 575 mg/kg/60D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,29,1994

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polychlorobenzenes, 5517
NTP Toxicity studies, RPT# TOX-07, October 2000
On EPA IRIS database
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