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Registry of Toxic Effects of Chemical Substances (RTECS)

1,2,4,5 Benzenetetracarboxylic 1,2:4,5 dianhydride

RTECS #

DB9300000

CAS #

89-32-7

Updated

April 2012

Molecular Weight

218.12

Molecular Formula

C10H2O6

Synonyms

1H,3H-Benzo(1,2-c:4,5-c')difuran-1,3,5,7-tetrone
Pyromellitic 1,2:4,5-dianhydride (6CI)
Pyromellitic acid anhydride
Pyromellitic acid dianhydride
Pyromellitic anhydride
Pyromellitic dianhydride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 mg severeTPKVAL 14,125,1975
skin /rabbit 50%/2D- intermittentTPKVAL 14,125,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 150 mg/m3/4H85GMAT -,105,1982
inhalation/rat lowest published toxic concentration: 106 mg/m3/4HKidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 14,125,1975
inhalation/rat lowest published toxic concentration: 70 mg/m3/4HNutritional and Gross Metabolic: Body temperature decreaseTPKVAL 14,125,1975
ocular/rabbit lowest published toxic dose: 25 mg/kgEye: Lacrimation

Eye: Conjunctiva irritation
TPKVAL 14,125,1975
oral/guinea pig lethal dose (50 percent kill): 1595 mg/kgBehavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
GISAAA 51(11),79,1986
oral/mouse lethal dose (50 percent kill): 2400 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness
TPKVAL 14,125,1975
oral/mouse lethal dose (16 percent kill): 1300 mg/kgTPKVAL 14,125,1975
oral/mouse lowest published lethal dose: 4000 mg/kgBehavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Vascular: Measurement of regional blood flow
TPKVAL 14,125,1975
oral/rat lethal dose (50 percent kill): 2250 mg/kgBehavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
GISAAA 51(11),79,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 500 µg/m3/5D- intermittentLung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increase in humoral response
TOXID9 60,173,2001
inhalation/rat lowest published toxic concentration: 20 mg/m3/30D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTPKVAL 14,125,1975
inhalation/rat lowest published toxic concentration: 20 mg/m3/122D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression

Liver: Fatty liver degeneration
TPKVAL 14,125,1975
oral/rat lowest published toxic dose: 1320 mg/kg/30D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GISAAA 51(11),79,1986

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84105; Number of Industries 4; Total Number of Facilities 64; Number of Occupations 3; Total Number of Employees Exposed 1926; Total Number of Female Employees Exposed 728
National Occupational Hazard Survey 1974Hazard Code 84105; Number of Industries 6; Total Number of Facilities 62; Number of Occupations 9; Total Number of Employees Exposed 721

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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