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1,2,4,5 Benzenetetracarboxylic 1,2:4,5 dianhydride

RTECS #: DB9300000

CAS #: 89-32-7


UPDATE: February 2008 MW: 218.12 MF: C10H2O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1H,3H - Benzo (1,2 - c:4,5 - c') difuran - 1,3,5,7 - tetrone
  2. Pyromellitic acid anhydride
  3. Pyromellitic acid dianhydride
  1. Pyromellitic anhydride
  2. Pyromellitic dianhydride
  3. Pyromellitic 1,2:4,5 - dianhydride (6CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 mg severe TPKVAL 14,125,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 150 mg/m3/4 hour N/R 85GMAT -,105,1982
inhalation
rat
lowest published toxic concentration: 106 mg/m3/4 hour Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 14,125,1975
inhalation
rat
lowest published toxic concentration: 70 mg/m3/4 hour Nutritional and Gross Metabolic: Body temperature decrease TPKVAL 14,125,1975
ocular
rabbit
lowest published toxic dose: 25 mg/kg Eye: Lacrimation

Eye: Conjunctiva irritation
TPKVAL 14,125,1975
oral
guinea pig
lethal dose (50 percent kill): 1,595 mg/kg Behavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
GISAAA 51(11),79,1986
oral
mouse
lethal dose (50 percent kill): 2,400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness
TPKVAL 14,125,1975
oral
mouse
lethal dose (16 percent kill): 1,300 mg/kg N/R TPKVAL 14,125,1975
oral
mouse
lethal dose : 4,000 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Vascular: Measurement of regional blood flow
TPKVAL 14,125,1975
oral
rat
lethal dose (50 percent kill): 2,250 mg/kg Behavioral: Excitement

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
GISAAA 51(11),79,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 500 g/m3/5 day- intermittent Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increase in humoral response
TOXID9 60,173,2001
inhalation
rat
lowest published toxic concentration: 20 mg/m3/30 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TPKVAL 14,125,1975
inhalation
rat
lowest published toxic concentration: 20 mg/m3/122 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression

Liver: Fatty liver degeneration
TPKVAL 14,125,1975
oral
rat
lowest published toxic dose: 1,320 mg/kg/30 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GISAAA 51(11),79,1986
skin
rabbit
lowest published toxic dose: 50 pph/2 day- intermittent Skin: After topical application: Primary irritation TPKVAL 14,125,1975


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84105;
Number of Industries 6;
Total Number of Facilities 62;
Number of Occupations 9;
Total Number of Employees Exposed 721
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84105;
Number of Industries 4;
Total Number of Facilities 64;
Number of Occupations 3;
Total Number of Employees Exposed 1,926;
Total Number of Female Employees Exposed 728


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

NIOSH PROFILE (ORGANIC ANHYDRIDES), SRC, 2/82

RTECS Compound Description:
   Primary Irritant

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