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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzenesulfonic acid, 4,4'-oxybis-, dihydrazide

RTECS #

DB7321000

CAS #

80-51-3

Updated

September 201

Molecular Weight

358.42

Molecular Formula

C12H14N4O5S2

Synonyms

Benzenesulfonic acid, oxybis-, dihydrazide (9CI)
Cellmic S
Celogen OT
Cenitron OB
OBSH
Oxybis(benzenesulfonylhydrazide)
Oxybisbenzenesulfonic acid dihydrazide
p,p'-Oxybis(benzenesulfonyl hydrazide)
p,p'-Oxybisbenzene disulfonylhydrazide

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 50 mgHPV077 -,-,2003

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repairliver/rat100 µmol/LJJCREP 79,204,1988
DNA repairliver/mouse100 µmol/LJJCREP 79,204,1988
mutation in microorganisms/Salmonella typhimurium800 µg/plate (+enzymatic activation step)NEZAAQ 33,474,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): >5000 mg/kgHPV077 -,-,2003
oral/rat lethal dose (50 percent kill): 2300 mg/kgHPV077 -,-,2003
skin/rabbit Lethal dose: >200 mg/kgHPV077 -,-,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 9000 mg/kg/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV077 -,-,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, MAR2002

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84832; Number of Industries 6; Total Number of Facilities 223; Number of Occupations 16; Total Number of Employees Exposed 5939; Total Number of Female Employees Exposed 282
National Occupational Hazard Survey 1974Hazard Code 84832; Number of Industries 5; Total Number of Facilities 115; Number of Occupations 10; Total Number of Employees Exposed 1078

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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