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Benzenesulfonic acid, 5 - chloro - 2 - ( (2 - hydroxy - 1 - naphthalenyl) azo) - 4 - methyl - , barium salt

RTECS #: DB5500000

CAS #: 5160-02-1


UPDATE: November 2007 MW: 444.49 MF: C17H12ClN2O4S1/2Ba


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - (4 - Chloro - o - sulfo - 5 - tolylazo) - 2 - naphthol, barium salt
  2. 1 - (4 - Chloro - o - sulpho - 5 - tolylazo) - 2 - naphthol, barium salt
  3. 1860 Red
  4. 5 - Chloro - 2 - ( (2 - hydroxy - 1 - naphthalenyl) azo) - 4 - methylbenzenesulfonic acid, barium salt (2:1)
  5. 5 - Chloro - 2 - ( (2 - hydroxy - 1 - naphthalenyl) azo) - 4 - methylbenzenesulphonic acid, barium salt
  6. 5 - Chloro - 2 - ( (2 - hydroxy - 1 - naphthyl) azo) - p - toluenesulfonic acid, barium salt
  7. Astro Orange
  8. Atomic Red
  9. Brilliant Red
  10. Brilliant Scarlet CA
  11. Brilliant Scarlet CBA
  12. Brilliant Scarlet CTA
  13. Brilliant Toner Z
  14. Bronze Red 16913 Yellowish
  15. Bronze Red RO
  16. Bronze Scarlet
  17. Bronze Scarlet C
  18. Bronze Scarlet CA
  19. Bronze Scarlet CBA
  20. Bronze Scarlet CT
  21. Bronze Scarlet CTA
  22. Bronze Scarlet Toner
  23. C.I. 15585:1
  24. C.I. Pigment Red 53, barium salt
  25. C.I. Pigment Red 53:1
  26. Carnation Red
  27. Cosmetic Coral Red KO Bluish
  28. Cosmetic DVR
  29. Cosmetic Pigment Yellow Red DVR
  30. D & C Red No. 9
  31. D and C Red No. 9
  32. Dainichi Lake Red C
  33. Desert Red
  34. Duplex Red Lake C20 - 5925
  35. Eljon Lake Red C
  36. Hamilton Red
  37. Helio Red Toner LCLL
  38. Irgalite Red CBN
  39. Irgalite Red CBR
  40. Irgalite Red CBT
  41. Irgalite Red MBC
  42. Isol Lake Red LCS 12527
  43. Isol Red LCR 2517
  44. Lake Red 1520
  45. Lake Red C
  46. Lake Red C 18287
  47. Lake Red C 21245
  48. Lake Red C 27200
  49. Lake Red C 27217
  50. Lake Red C 27218
  51. Lake Red C Barium Toner
  52. Lake Red C Toner 8195
  53. Lake Red C Toner 8366
  54. Lake Red CC
  55. Lake Red CCT
  56. Lake Red CR
  57. Lake Red CRLC - 232 (barium)
  1. Lake Red GB barium salt
  2. Lake Red RRG
  3. Lake Red Toner C
  4. Lake Red Toner LCLL
  5. Latexol Scarlet R
  6. Latexol Scarlet R Solupowder
  7. Ld Rubber Red 16913
  8. Lutetia Red CLN
  9. Lutetia Red CLN - ST
  10. Microtex Lake Red CR
  11. Mohican Red A - 8008
  12. NCI - C53792
  13. No.3 Conc. Bronze Scarlet
  14. No.3 Conc. Scarlet
  15. Paridine Red LCL
  16. Pigment Lake Red BFC
  17. Pigment Lake Red CD
  18. Pigment Lake Red LC
  19. Pigment Red 53:1
  20. Pigment Red CD
  21. Potomac Red
  22. Recolite Red Lake C
  23. Recolite Red Lake CR
  24. Red 16913H
  25. Red 1860
  26. Red For Lake C
  27. Red For Lake C Toner RA - 5190
  28. Red For Lake Toner RA - 5190
  29. Red Lake C
  30. Red Lake C Toner
  31. Red Lake C Toner 20 - 5650
  32. Red Lake C Toner RA - 5190
  33. Red Lake CM 20 - 5650
  34. Red Lake CR - 1
  35. Red Lake R - 91
  36. Red Scarlet
  37. Red Toner Z
  38. Rubber Red 16913R
  39. Sanyo Lake Red C
  40. Scarlet Toner Y
  41. Segnale Red LCL
  42. Segnale Red LC
  43. Segnale Red LCG
  44. Sico Lake Red 2L
  45. Superol Red C RT - 265
  46. Symuler Lake Red C
  47. Termosolido Red LCG
  48. Texan Red Toner D
  49. Toner Lake Red C
  50. Transparent Bronze Scarlet
  51. Vulcafix Scarlet R
  52. Vulcafix Scarlet R - D masse
  53. Vulcafor Red 2R
  54. Vulcan Red LC
  55. Vulcol Fast Red L
  56. Wayne Red X - 2486


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) SCIEAS 236,933,1987
mutation in microorganisms Salmonella typhimurium 100 mg/L/2 hour (+enzymatic activation step) EMMUEG 44,329,2004


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 130 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Tumors
NTPTR* NTP-TR-225,1982
oral
rat
toxic dose : 109 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Blood: Tumors
FCTOD7 25,619,1987
oral
rat
lowest published toxic dose: 16,380 mg/kg/13 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Blood: Changes in spleen

Blood: Other changes
NTIS** PB82-229592
oral
rat
lowest published toxic dose: 27,300 mg/kg/13 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Blood: Changes in spleen

Blood: Other changes
NTIS** PB82-229592
oral
rat
lowest published toxic dose: 129,780 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors
NTIS** PB82-229592
oral
rat
lowest published toxic dose: 108,150 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB82-229592


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 21 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-225,1982
oral
mouse
lowest published toxic dose: 87,600 mg/kg/2 year- continuous Blood: Changes in erythrocyte (RBC) count NTIS** OTS0543935
oral
rat
lowest published toxic dose: 27,300 mg/kg/91 day- continuous Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-225,1982
oral
rat
lowest published toxic dose: 546 gm/kg/2 year- continuous Endocrine: Changes in spleen weight TXAPA9 4,200,1962
oral
rat
lowest published toxic dose: 43,260 mg/kg/103 week- continuous Blood: Leukemia

Reproductive: Tumorigenic effects: Testicular tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB82-229592
oral
rat
lowest published toxic dose: 36,050 mg/kg/103 week- continuous Blood: Leukemia

Tumorigenic: Active as anti-cancer agent
NTIS** PB82-229592


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 57,203,1993
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 8,107,1975
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 8,107,1975
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 57,203,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 57,203,1993
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg(Ba)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 0.5 mg(Ba)/m3, FEB 2006
Occupational Exposure Limit - GERMANY MAK 0.5 mg(Ba)/m3 (inhalable), 2005
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg(Ba)/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg(Ba)/m3, 2003
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Ba)/m3, 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3849;
Number of Industries 15;
Total Number of Facilities 1,160;
Number of Occupations 21;
Total Number of Employees Exposed 14,370
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3849;
Number of Industries 43;
Total Number of Facilities 8,245;
Number of Occupations 49;
Total Number of Employees Exposed 122,313;
Total Number of Female Employees Exposed 23,095


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of its alkaline earth metal salts, in cosmetics and in drugs
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Bioassay (feed);clear evidence:rat NTPTR* NTP-TR-225,1982
NCI Carcinogenesis Studies (feed);equivocal evidence:rat
NTP Carcinogenesis Bioassay (feed);no evidence:mouse NTPTR* NTP-TR-225,1982


REFERENCES:

CODEN
REFERENCE

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in the manufacture of its alkaline earth metal salts, in cosmetics and in drugs

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: 12237-52-4
ALT CAS #: 12238-39-0
ALT CAS #: 12238-41-4
ALT CAS #: 12238-43-6
ALT CAS #: 24777-23-9
ALT CAS #: 52627-68-6
ALT CAS #: 68894-03-1
Click Here for Additional Information about RTECS

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