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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, pentachloronitro-

RTECS #

DA6650000

CAS #

82-68-8; 39378-26-2

Updated

September 201

Molecular Weight

295.32

Molecular Formula

C6Cl5NO2

Synonyms

Avicol (pesticide)
Avicolreg
Batrilex
Benzene, nitropentachloro-
Botrilex
Botrilexreg
Brassicol
Brassicol 75
Brassicol super
Brassicolreg
Chinozan
Earthcide
Fartox
Folosan
Folosanreg
Fomac 2
Fungiclor
GC 3944-3-4
HOE 026014
Kobutol
Marisan forte
NCI-C00419
Olpisan
PCNB
Pentachlornitrobenzol (German)
Pentachloronitrobenzene
Pentachloronitrobenzene (ACGIH)
Pentagen
PKhNB
PKhNb
Quinosan
Quintocene
Quintozen
Quintozene
RCRA waste number U185
RTU 1010
Saniclor 30
Terrachlor
Terraclor
Terraclorreg
Terrafun
Terrazan
Tilcarex
Tilcarexreg
Tri-pcnb
Tritisan
Tritosanreg

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster7500 µg/LEMMUEG 10(Suppl 10),1,1987
Cytogenetic Analysislung/hamster8.1 µmol/LMUREAV 608,28,2006
Cytogenetic Analysisoral/hamster8.1 µmol/LMUREAV 608,28,2006
DNA adduct/Escherichia coli20 µmol/LMUREAV 89,95,1981
DNA repair/Salmonella typhimurium1 mg/discJPFCD2 21,319,1986
gene conversion and mitotic recombination/Aspergillus nidulans40 µmol/LMUREAV 147,288,1985
mutation in microorganisms/Escherichia coli10 mg/plate (-enzymatic activation step)MUREAV 11,247,1971
mutation in microorganisms/Aspergillus nidulans5 µmol/L (-enzymatic activation step)PHYTAJ 66,217,1976
sex chromosome loss and nondisjunction/Aspergillus nidulans17 µmol/LEVHPAZ 31,81,1979

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 5 gm/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on embryo or fetus: Fetal death
TXAPA9 35,239,1976
oral/mouse 1935 mg/kg (6-14D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** PB223-160
oral/mouse 4176 mg/kg (6-10D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
NTIS** PB223-160
oral/mouse 4176 mg/kg (6-14D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)NTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 135 gm/kg/77W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
JNCIAM 42,1101,1969

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 2 gm/m385GMAT -,96,1982
inhalation/rat lethal concentration (50 percent kill): 1400 mg/m385GMAT -,96,1982
intraperitoneal/mouse lethal dose (50 percent kill): 4500 mg/kgARTODN 51,329,1982
intraperitoneal/rat lethal dose (50 percent kill): 5 gm/kg85INA8 5,462.1(89),1986
oral/Dog lethal dose (50 percent kill): >2500 mg/kgENTOX* -,341,2005
oral/Dog Lethal dose: >2500 mg/kgGastrointestinal: Nausea or vomitingAIPTAK 114,38,1958
oral/mouse lethal dose (50 percent kill): 1400 mg/kg85GMAT -,96,1982
oral/rabbit lethal dose (50 percent kill): 800 mg/kgAIPTAK 114,38,1958
oral/rat lethal dose (50 percent kill): 1100 mg/kgFAATDF 7,299,1986
skin/rabbit Lethal dose: >4 gm/kgTXAPA9 18,522,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mammal (species unspecified) lowest published toxic dose: 62660 mg/kg/30D- continuousBehavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** PB288-416
oral/mouse lowest published toxic dose: 13650 mg/kg/13W- intermittentLiver: Changes in liver weightNTPTR* NTP-TR-325,1987
oral/rat lowest published toxic dose: 11250 mg/kg/90D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIPTAK 114,38,1958

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 5,211,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 5,211,1974
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWRREVAH 56,107,1975
TOXICOLOGY REVIEW85CVA2 5,250,1970
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWENTOX* -,341,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWFEREAC 74,22478,2009
TOXICOLOGY REVIEWFEREAC 74,47451,2009
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWREPTED 31,392,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,140,1998
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg/m3, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 mg/m3, NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,5 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0806; Number of Industries 1; Total Number of Facilities 38; Number of Occupations 2; Total Number of Employees Exposed 574; Total Number of Female Employees Exposed 77
National Occupational Hazard Survey 1974Hazard Code M0806; Number of Industries 1; Total Number of Facilities 18; Number of Occupations 1; Total Number of Employees Exposed 18

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: TRP reversion; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse
NTP Carcinogenesis Studies (feed);no evidence:mouse NTPTR* NTP-TR-325,1987
On EPA IRIS database
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