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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, pentachloro-

RTECS #

DA6640000

CAS #

608-93-5

Updated

November 2007

Molecular Weight

250.32

Molecular Formula

C6HCl5

Synonyms

1,2,3,4,5-Pentachlorobenzene
PCB
Pentachlorobenzene
QCB
RCRA waste number U183

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageoral/rat1500 ng/kg/30W- intermittentJJTHEC 65,825,2002

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 2 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTXCYAC 5,117,1975
oral/rat 1802 mg/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTIS** PB91-185983
oral/rat 2000 mg/kg (6-15D pregnant)Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXCYAC 5,117,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 1 mg/kgLiver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TXAPA9 111,69,1991
intraperitoneal/rat lowest published toxic dose: 2 mg/kgKidney, Ureter, and Bladder: Changes in kidney weightTXAPA9 111,69,1991
oral/mouse lethal dose (50 percent kill): 1175 mg/kgBehavioral: General anesthetic

Behavioral: Tremor
JEPTDQ 4(5-6),183,1980
oral/mouse lethal dose (50 percent kill): 1175 mg/kgENTOX* -,340,2005
oral/rat lethal dose (50 percent kill): 940 mg/kgENTOX* -,340,2005
oral/rat lethal dose (50 percent kill): 1080 mg/kgBehavioral: General anesthetic

Behavioral: Tremor
JEPTDQ 4(5-6),183,1980
skin/rat lethal dose (50 percent kill): >2500 mg/kgJEPTDQ 4(5-6),183,1980

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 5940 mg/kg/15D- continuousPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Tremor

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NIH-91-3125
oral/mouse lowest published toxic dose: 10909 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
NTPTR* NIH-91-3125
oral/rat lowest published toxic dose: 1500 ng/kg/30W- intermittentBrain and Coverings: Other degenerative changesJJTHEC 65,825,2002
oral/rat lowest published toxic dose: 4500 ng/kg/30W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)JJTHEC 65,825,2002
oral/rat lowest published toxic dose: 1662 mg/kg/28D- continuousLiver: Changes in liver weightJTEHD6 11,663,1983
oral/rat lowest published toxic dose: 248 mg/kg/15D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-91-3125
oral/rat lowest published toxic dose: 9 gm/kg/26W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in leukocyte (WBC) count
JEPTDQ 4(5-6),183,1980
oral/rat lowest published toxic dose: 1738 mg/kg/13W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Endocrine: Adrenal cortex hyperplasia

Blood: Other changes
TXAPA9 119,181,1993

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 127,101,2002
TOXICOLOGY REVIEWENTOX* -,340,2005

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polychlorobenzenes, 5517
NTP Toxicity studies, RPT# TOX-06, October 2000
On EPA IRIS database
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