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Benzene, pentachloro -

RTECS #: DA6640000

CAS #: 608-93-5


UPDATE: November 2007 MW: 250.32 MF: C6HCl5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,2,3,4,5 - Pentachlorobenzene
  2. PCB
  3. Pentachlorobenzene
  1. QCB
  2. RCRA waste number U183


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage oral
rat
1,500 ng/kg/30 week- intermittent JJTHEC 65,825,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXCYAC 5,117,1975
oral
rat
lowest published toxic dose: 1,802 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** PB91-185983
oral
rat
lowest published toxic dose: 2,000 mg/kg (6-15 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXCYAC 5,117,1975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 1 mg/kg Liver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TXAPA9 111,69,1991
intraperitoneal
rat
lowest published toxic dose: 2 mg/kg Kidney, Ureter, and Bladder: Changes in kidney weight TXAPA9 111,69,1991
oral
mouse
lethal dose (50 percent kill): 1,175 mg/kg Behavioral: General anesthetic

Behavioral: Tremor
JEPTDQ 4(5-6),183,1980
oral
mouse
lethal dose (50 percent kill): 1,175 mg/kg N/R ENTOX* -,340,2005
oral
rat
lethal dose (50 percent kill): 1,080 mg/kg Behavioral: General anesthetic

Behavioral: Tremor
JEPTDQ 4(5-6),183,1980
oral
rat
lethal dose (50 percent kill): 940 mg/kg N/R ENTOX* -,340,2005
skin
rat
lethal dose (50 percent kill): >2,500 mg/kg N/R JEPTDQ 4(5-6),183,1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 5,940 mg/kg/15 day- continuous Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Tremor

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NIH-91-3125
oral
mouse
lowest published toxic dose: 10,909 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
NTPTR* NIH-91-3125
oral
rat
lowest published toxic dose: 1,662 mg/kg/28 day- continuous Liver: Changes in liver weight JTEHD6 11,663,1983
oral
rat
lowest published toxic dose: 248 mg/kg/15 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-91-3125
oral
rat
lowest published toxic dose: 9 gm/kg/26 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in leukocyte (WBC) count
JEPTDQ 4(5-6),183,1980
oral
rat
lowest published toxic dose: 1,738 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Endocrine: Adrenal cortex hyperplasia

Blood: Other changes
TXAPA9 119,181,1993
oral
rat
lowest published toxic dose: 1,500 ng/kg/30 week- intermittent Brain and Coverings: Other degenerative changes JJTHEC 65,825,2002
oral
rat
lowest published toxic dose: 4,500 ng/kg/30 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JJTHEC 65,825,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 127,101,2002
TOXICOLOGY REVIEW
ENTOX* -,340,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a fungicide and to protect wood from fungal rots and wood-boring insects
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polychlorobenzenes, 5517
NTP Toxicity studies, RPT# TOX-06, October 2000


REFERENCES:

CODEN
REFERENCE

ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJTHEC Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a fungicide and to protect wood from fungal rots and wood-boring insects

RTECS Compound Description:
   Tumorigen
   Drug
   Reproductive Effector

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