RTECS:DA6626666 The Registry of Toxic Effects of Chemical Substances

Benzene, 1,1' - oxybis - , octabromo deriv.

RTECS #: DA6626666

CAS #: 32536-52-0

UPDATE: November 2007 MW: 801.42 MF: C₁₂H₂Br₈O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

1,1' - Oxybisbenzene octabromo deriv.

Bromkal 79 - 8DE

CD 79

DE 79

DE - 79

EB 8

FR 1208

FR 143

Octabromobiphenyl ether

Octabromodiphenyl ether

Octabromodiphenyl oxide

Phenyl ether, octabromo deriv. (8CI)

Tardex 80

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lethal concentration : >60 gm/m³/1 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Skin: After systemic exposure: Dermatitis, other NTIS OTS0522296
inhalation
rat lethal concentration (50 percent kill): 60 gm/m³/1 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea EVHPAZ 109,49,2001
oral
rat lethal dose : >5 gm/kg N/R NTIS OTS0522296
oral
rat lethal dose (50 percent kill): 5 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea EVHPAZ 109,49,2001
skin
rabbit lethal dose : >2 gm/kg N/R NTIS OTS0522296
skin
rabbit lethal dose (50 percent kill): 2 gm/kg/24 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea EVHPAZ 109,49,2001

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 120 mg/m³/8 hour/14 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight NTIS OTS0522293
oral
mammal (species unspecified) lowest published toxic dose: 1,122 mg/kg/2 week- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) VCVGK* -,315,1994
oral
rat lowest published toxic dose: 40 mg/kg/4 day- intermittent Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOSCF2 61,76,2001
oral
rat lowest published toxic dose: 39,040 mg/kg/122 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,315,1994
oral
rat lowest published toxic dose: 120 mg/kg/4 day- intermittent Liver: Changes in liver weight TOSCF2 61,76,2001
oral
rat lowest published toxic dose: 280 mg/kg/28 day- continuous Liver: Other changes EVHPAZ 109,49,2001
oral
rat lowest published toxic dose: 910 mg/kg/13 week- continuous Liver: Changes in liver weight EVHPAZ 109,49,2001

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
ENTOX* -,507,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

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SYNONYMS:
1,1' - Oxybisbenzene octabromo deriv. Bromkal 79 - 8DE CD 79 DE 79 DE - 79 EB 8 FR 1208	FR 143 Octabromobiphenyl ether Octabromodiphenyl ether Octabromodiphenyl oxide Phenyl ether, octabromo deriv. (8CI) Tardex 80

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lethal concentration : >60 gm/m³/1 hour	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory stimulation Skin: After systemic exposure: Dermatitis, other	NTIS** OTS0522296
inhalation rat	lethal concentration (50 percent kill): 60 gm/m³/1 hour	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea	EVHPAZ 109,49,2001
oral rat	lethal dose : >5 gm/kg	N/R	NTIS** OTS0522296
oral rat	lethal dose (50 percent kill): 5 gm/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea	EVHPAZ 109,49,2001
skin rabbit	lethal dose : >2 gm/kg	N/R	NTIS** OTS0522296
skin rabbit	lethal dose (50 percent kill): 2 gm/kg/24 hour	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea	EVHPAZ 109,49,2001

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 120 mg/m³/8 hour/14 day- intermittent	Lung, Thorax, or Respiration: Other changes Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Changes in liver weight	NTIS** OTS0522293
oral mammal (species unspecified)	lowest published toxic dose: 1,122 mg/kg/2 week- intermittent	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	VCVGK* -,315,1994
oral rat	lowest published toxic dose: 40 mg/kg/4 day- intermittent	Endocrine: Evidence of thyroid hypofunction Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TOSCF2 61,76,2001
oral rat	lowest published toxic dose: 39,040 mg/kg/122 day- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,315,1994
oral rat	lowest published toxic dose: 120 mg/kg/4 day- intermittent	Liver: Changes in liver weight	TOSCF2 61,76,2001
oral rat	lowest published toxic dose: 280 mg/kg/28 day- continuous	Liver: Other changes	EVHPAZ 109,49,2001
oral rat	lowest published toxic dose: 910 mg/kg/13 week- continuous	Liver: Changes in liver weight	EVHPAZ 109,49,2001

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		TOLED5 127,111,2002
TOXICOLOGY REVIEW		ENTOX* -,507,2005

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
N/R	N/R	N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ	EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2	Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.