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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, 1,1'-oxybis-, octabromo deriv.

RTECS #

DA6626666

CAS #

32536-52-0

Updated

December 2013

Molecular Weight

801.42

Molecular Formula

C12H2Br8O

Synonyms

1,1'-Oxybisbenzene octabromo deriv.
Bromkal 79-8DE
CD 79
DE 79
DE-79
EB 8
FR 1208
FR 143
Octabromobiphenyl ether
Octabromodiphenyl ether
Octabromodiphenyl oxide
Phenyl ether, octabromo deriv. (8CI)
Tardex 80

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/paaInhibitor Concentration Low: 10 mg/L/30MBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphokinaseTXAPA9 245,1,2010
inhalation/rat lethal concentration (50 percent kill): 60 gm/m3/1HBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
inhalation/rat Lethal concentration: >60 gm/m3/1HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0522296
oral/rat lethal dose (50 percent kill): 5 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
oral/rat Lethal dose: >5 gm/kgNTIS** OTS0522296
skin/rabbit lethal dose (50 percent kill): 2 gm/kg/24HBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
skin/rabbit Lethal dose: >2 gm/kgNTIS** OTS0522296

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 120 mg/m3/8H/14D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight
NTIS** OTS0522293
oral/mammal (species unspecified) lowest published toxic dose: 1122 mg/kg/2W- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
VCVGK* -,315,1994
oral/rat lowest published toxic dose: 39040 mg/kg/122D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,315,1994
oral/rat lowest published toxic dose: 120 mg/kg/4D- intermittentLiver: Changes in liver weightTOSCF2 61,76,2001
oral/rat lowest published toxic dose: 280 mg/kg/28D- continuousLiver: Other changesEVHPAZ 109,49,2001
oral/rat lowest published toxic dose: 910 mg/kg/13W- continuousLiver: Changes in liver weightEVHPAZ 109,49,2001
oral/rat lowest published toxic dose: 40 mg/kg/4D- intermittentEndocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOSCF2 61,76,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 127,111,2002
TOXICOLOGY REVIEWENTOX* -,507,2005

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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