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Benzene, 1,1' - oxybis - , octabromo deriv.

RTECS #: DA6626666

CAS #: 32536-52-0


UPDATE: November 2007 MW: 801.42 MF: C12H2Br8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 1,1' - Oxybisbenzene octabromo deriv.
  2. Bromkal 79 - 8DE
  3. CD 79
  4. DE 79
  5. DE - 79
  6. EB 8
  7. FR 1208
  1. FR 143
  2. Octabromobiphenyl ether
  3. Octabromodiphenyl ether
  4. Octabromodiphenyl oxide
  5. Phenyl ether, octabromo deriv. (8CI)
  6. Tardex 80


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration : >60 gm/m3/1 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0522296
inhalation
rat
lethal concentration (50 percent kill): 60 gm/m3/1 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
oral
rat
lethal dose : >5 gm/kg N/R NTIS** OTS0522296
oral
rat
lethal dose (50 percent kill): 5 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001
skin
rabbit
lethal dose : >2 gm/kg N/R NTIS** OTS0522296
skin
rabbit
lethal dose (50 percent kill): 2 gm/kg/24 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
EVHPAZ 109,49,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 120 mg/m3/8 hour/14 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight
NTIS** OTS0522293
oral
mammal (species unspecified)
lowest published toxic dose: 1,122 mg/kg/2 week- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
VCVGK* -,315,1994
oral
rat
lowest published toxic dose: 40 mg/kg/4 day- intermittent Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOSCF2 61,76,2001
oral
rat
lowest published toxic dose: 39,040 mg/kg/122 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,315,1994
oral
rat
lowest published toxic dose: 120 mg/kg/4 day- intermittent Liver: Changes in liver weight TOSCF2 61,76,2001
oral
rat
lowest published toxic dose: 280 mg/kg/28 day- continuous Liver: Other changes EVHPAZ 109,49,2001
oral
rat
lowest published toxic dose: 910 mg/kg/13 week- continuous Liver: Changes in liver weight EVHPAZ 109,49,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
ENTOX* -,507,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

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