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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, isocyanato-

RTECS #

DA3675000

CAS #

103-71-9

Updated

April 2012

Molecular Weight

119.13

Molecular Formula

C7H5NO

Synonyms

Carbanil
Fenylisokyanat (Czech)
Isocyanic acid, phenyl ester
Karbanil (Czech)
Mondur P
Phenyl carbonimide
Phenylcarbimide

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)ABCHA6 44,3017,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 22 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Cyanosis
NTIS** OTS0530489
intraperitoneal/mouse lethal dose (50 percent kill): 50 mg/kgEye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis
NTIS** OTS0528337
intraperitoneal/rat lethal dose (50 percent kill): 100 mg/kgEye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor
NTIS** OTS0528337
oral/mouse lethal dose (50 percent kill): 196 mg/kgEESADV 17,258,1989
oral/rat lethal dose (50 percent kill): 800 mg/kgEye: Other eye effects

Behavioral: Somnolence (general depressed activity)
NTIS** OTS0528337
skin/rabbit lethal dose (50 percent kill): 7130 mg/kgTXAPA9 42,417,1977
skin/rat lethal dose (50 percent kill): 5 mL/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Aggression

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0528430
subcutaneous/mouse lethal dose (50 percent kill): 1400 mg/kgYAKUD5 9,759,1967

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 7 mg/m3/6H/2W- intermittentEye: Other eye effects

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Blood: Changes in erythrocyte (RBC) count
FAATDF 24,217,1995
inhalation/rat lowest published toxic concentration: 500 ppb/6H/3W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Pigmented or nucleated red blood cells

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0528433

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 140-141,183,2003

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.01 ppm (0.05 mg/m3);KZW 0.01 ppm (0.05 mg/m3), sen, 2007
Occupational Exposure Limit-FINLANDshort term exposure limit 0.02 ppm (0.1 mg/m3), NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.005 ppm (0.02 mg/m3), short term exposure limit 0.01 ppm (0.05 mg/m3), sen, NOV2011
Occupational Exposure Limit-PERUtime-weighted average 0,01 ppm (0,49 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.005 ppm (0.02 mg/m3), ceiling concentration 0.01 ppm (0.05 mg/m3), Sen, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83340; Number of Industries 4; Total Number of Facilities 161; Number of Occupations 5; Total Number of Employees Exposed 1453; Total Number of Female Employees Exposed 474
National Occupational Hazard Survey 1974Hazard Code 83340; Number of Industries 4; Total Number of Facilities 79; Number of Occupations 7; Total Number of Employees Exposed 325

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9105;8EHQ-0892-9121
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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