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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, 1-chloro-3-nitro-

RTECS #

CZ0940000

CAS #

121-73-3

Updated

July 2012

Molecular Weight

157.56

Molecular Formula

C6H4ClNO2

Synonyms

1-Chloro-3-nitrobenzene
1-Nitro-3-chlorobenzene
Chloro-m-nitrobenzene
m-Chloronitrobenzene
m-Nitrochlorobenzene

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 380 mg/kgGTPZAB 25(8),50,1981
oral/rat lethal dose (50 percent kill): 420 mg/kg85GMAT -,92,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 80 µg/m3/24H/73D- continuousBehavioral: Muscle contraction or spasticityGISAAA 35(4),44,1970
oral/rat lowest published toxic dose: 1200 mg/kg/20D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV175 -,-,2003

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 65,263,1996
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 65,263,1996
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 65,263,1996
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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