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Benzene, (epoxyethyl) -

RTECS #: CZ9625000

CAS #: 96-09-3


UPDATE: May 2009 MW: 120.16 MF: C8H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,2 - Epoxy - 1 - phenylethane
  2. 1,2 - Epoxyethylbenzene
  3. 1 - Phenyl - 1,2 - epoxyethane
  4. 1 - Phenyloxirane
  5. 2 - Phenyloxirane
  6. EP - 182
  7. Epoxyethylbenzene (8CI)
  8. Epoxystyrene
  9. Fenyloxiran (Czech)
  10. NCI - C54977
  1. Oxirane, phenyl -
  2. Phenethylene oxide
  3. Phenyl oxirane
  4. Phenylethylene oxide
  5. SO
  6. Styrene epoxide
  7. Styrene oxide
  8. Styrene - 7,8 - oxide
  9. Styryl oxide
  10. alpha,beta - Epoxystyrene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis intraperitoneal
hamster
500 mg/kg CBINA8 26,305,1979
cytogenetic analysis hamster lung 57 mg/L GMCRDC 27,95,1981
cytogenetic analysis human lymphocyte 100 µmol/L MUREAV 190,221,1987
DNA adduct human fibroblast 3 mmol/L/2 hour MUREAV 484,3,2001
DNA damage human leukocyte 50 µmol/well/30 minute TOLED5 126,61,2002
DNA damage human leukocyte 0.5 mmol/L/30 minute MUREAV 536,49,2003
DNA damage human mammary gland 8.7 mg/L/24 hour (-enzymatic activation step) MUREAV 588,47,2005
DNA damage intraperitoneal
mouse
3,500 µmol/kg CALEDQ 21,9,1983
DNA damage other microorganisms 1 mmol/L MUREAV 368,235,1996
DNA damage rat other cell types 30 µmol/L CRNGDP 13,417,1992
DNA damage rat liver 300 µmol/L SinJF# 26OCT1982
DNA inhibition human HeLa cell 4,400 µmol/L MUREAV 93,447,1982
DNA repair Escherichia coli 5 µg/well MUREAV 133,161,1984
DNA repair human lymphocyte 200 µmol/L/24 hour MUTAEX 16,127,2001
unscheduled DNA synthesis human lymphocyte 100 µmol/L MUREAV 395,37,1997
unscheduled DNA synthesis human other cell types 4,400 µmol/L FCTXAV 18,434,1980
host-mediated assay mouse
Saccharomyes cerevisiae
100 mg/kg MUREAV 40,317,1976
host-mediated assay mouse
Schizosaccharomyces pombe
100 mg/kg MUREAV 40,317,1976
mutation in microorganisms Bacillus subtilis 5 mmol/L (-enzymatic activation step) MSERDS 5,131,1981
mutation in microorganisms Escherichia coli 2 mmol/L (-enzymatic activation step) CMSHAF 7,737,1978
mutation in microorganisms Klebsiella pneumoniae 500 µmol/L (-enzymatic activation step) MUREAV 89,269,1981
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) JOPHDQ 1,301,1978
mutation in microorganisms Salmonella typhimurium 500 µg/plate (-enzymatic activation step) PNASA6 72,5135,1975
mutation in microorganisms Schizosaccharomyces pombe 10 mmol/L (-enzymatic activation step) COINAV 256,315,1977
mutation in microorganisms Schizosaccharomyces pombe 5 mmol/L (+enzymatic activation step) MUREAV 40,317,1976
micronucleus test human leukocyte 100 µmol/L/30 minute MUREAV 491,163,2001
micronucleus test human leukocyte 0.5 mmol/L/40 hour MUREAV 536,49,2003
gene conversion and mitotic recombination Saccharomyes cerevisiae 20 mmol/L MUREAV 40,317,1976
gene conversion and mitotic recombination Schizosaccharomyces pombe 20 mmol/L COINAV 256,315,1977
mutation in mammalian somatic cells hamster fibroblast 17 mmol/L/60 minute MUREAV 40,317,1976
mutation in mammalian somatic cells hamster lung 2,080 µmol/L/2 hour CBINA8 39,57,1982
mutation in mammalian somatic cells mouse lymphocyte 13,800 µg/L MUREAV 97,49,1982
other mutation test systems Escherichia coli 300 µmol/L MUREAV 231,205,1990
other mutation test systems mouse fibroblast 1 µmol/L CRNGDP 6,1367,1985
other mutation test systems Salmonella typhimurium 70 µg/L MUREAV 192,239,1987
sister chromatid exchange intraperitoneal
hamster
500 mg/kg CBINA8 26,305,1979
sister chromatid exchange hamster ovary 25 mg/L CBINA8 20,163,1978
sister chromatid exchange hamster lung 100 mg/L CNREA8 44,3270,1984
sister chromatid exchange human lymphocyte 100 µmol/L CRNGDP 1,357,1980
sister chromatid exchange human leukocyte 50 µmol/L/30 minute MUREAV 491,163,2001
sister chromatid exchange inhalation
mouse
50 ppm/5 hour- continuous EVSRBT 25,433,1982
sister chromatid exchange rat lymphocyte 60 mg/L/72 hour MUREAV 472,85,2000
specific locus test human other cell types 1.25 mmol/L/1 hour EMMUEG 37,285,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 100 ppm/7 hour (1-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
SWEHDO 7(Suppl 4),66,1981
inhalation
rat
lowest published toxic concentration: 100 ppm/7 hour (1-19 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB81-168510
inhalation
rat
lowest published toxic concentration: 100 ppm/7 hour (1-19 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
SWEHDO 9,94,1983
inhalation
rabbit
lowest published toxic concentration: 15 ppm/7 hour (1-24 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** PB81-168510


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 273 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
JJIND8 77,471,1986
oral
rat
lowest published toxic dose: 65 gm/kg/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
ANYAA9 534,203,1988
oral
rat
lowest published toxic dose: 10 gm/kg/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
MELAAD 70,358,1979
oral
rat
toxic dose : 52 gm/kg/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
MELAAD 70,358,1979
oral
rat
toxic dose : 200 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
JJIND8 77,471,1986
skin
mouse
lowest published toxic dose: 74 gm/kg/62 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
JNCIAM 31,41,1963
unreported route
mouse
lowest published toxic dose: 96 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
RARSAM 3,193,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 500 ppm/4 hour N/R AMIHBC 10,61,1954
intraperitoneal
mouse
lowest published toxic dose: 300 mg/kg Lung, Thorax, or Respiration: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 150,335,2004
intraperitoneal
mouse
lowest published toxic dose: 300 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 227,165,2006
intraperitoneal
mouse
lowest published toxic dose: 300 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases TOXID9 227,217,2006
intraperitoneal
rat
lethal dose (50 percent kill): 460 mg/kg N/R TXAPA9 18,321,1971
oral
guinea pig
lethal dose (50 percent kill): 2 gm/kg N/R NTIS** PB81-168510
oral
mouse
lethal dose (50 percent kill): 1,500 mg/kg N/R JJIND8 77,471,1986
oral
rat
lethal dose (50 percent kill): 2 gm/kg N/R NTIS** PB81-168510
skin
rabbit
lethal dose (50 percent kill): 890 µL/kg N/R UCDS** 7/21/1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 8,400 mg/kg/7 week- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
JTSCDR 14,1,1989
intraperitoneal
rat
lowest published toxic dose: 350 mg/kg/14 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
BECTA6 34,722,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 36,245,1985
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 60,321,1994
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 36,245,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,321,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 60,321,1994
TOXICOLOGY REVIEW
TOLED5 138,75,2003
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
MUREAV 627,10,2007
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 544,339,2003
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
MUREAV 672,17,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84819;
Number of Industries 2;
Total Number of Facilities 59;
Number of Occupations 5;
Total Number of Employees Exposed 1,740
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84819;
Number of Industries 2;
Total Number of Facilities 109;
Number of Occupations 4;
Total Number of Employees Exposed 458


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: In vitro human lymphocyte micronucleus
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Weakly Positive: S pombe-forward mutation
EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a reactive diluent in epoxy resins and as an intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Studies (gavage);clear evidence:mouse,rat JJIND8 77,471,1986
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
COINAV Colloques Internationaux du Centre National de la Recherche Scientifique. (Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1946-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925-
MSERDS Microbiology Series. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1973-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued.
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as a reactive diluent in epoxy resins and as an intermediate

NIOSH PROFILE (ORGANIC OXIDES OR EPOXY COMPOUNDS), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 62497-63-6
Click Here for Additional Information about RTECS

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