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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, (epoxyethyl)-

RTECS #

CZ9625000

CAS #

96-09-3; 62497-63-6

Updated

December 2013

Molecular Weight

120.16

Molecular Formula

C8H8O

Synonyms

1,2-Epoxy-1-phenylethane
1,2-Epoxyethylbenzene
1-Phenyl-1,2-epoxyethane
1-Phenyloxirane
2-Phenyloxirane
alpha,beta-Epoxystyrene
EP-182
Epoxyethylbenzene (8CI)
Epoxystyrene
Fenyloxiran (Czech)
NCI-C54977
Oxirane, phenyl-
Phenethylene oxide
Phenyl oxirane
Phenylethylene oxide
SO
Styrene epoxide
Styrene oxide
Styrene-7,8-oxide
Styryl oxide

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human100 µmol/LMUREAV 190,221,1987
Cytogenetic Analysisintraperitoneal/hamster500 mg/kgCBINA8 26,305,1979
Cytogenetic Analysislung/hamster57 mg/LGMCRDC 27,95,1981
DNA adductfibroblast/human3 mmol/L/2HMUREAV 484,3,2001
DNA Damageleukocyte/human50 µmol/well/30MTOLED5 126,61,2002
DNA Damage/Other microorganisms1 mmol/LMUREAV 368,235,1996
DNA Damageother cell types/rat30 µmol/LCRNGDP 13,417,1992
DNA Damageliver/rat300 µmol/LSinJF# 26OCT1982
DNA Damageintraperitoneal/mouse3500 µmol/kgCALEDQ 21,9,1983
DNA Damageleukocyte/human0.05 mmol/L/30MMUREAV 536,49,2003
DNA Damagemammary gland/human8.7 mg/L/24H (-enzymatic activation step)MUREAV 588,47,2005
DNA Damageother cell types/mouse80 µmol/LMUREAV 715,25,2011
DNA Damageleukocyte/human80 µmol/L/2HMUREAV 747,1,2012
DNA Damageleukocyte/human80 µmol/L/24HMUREAV 747,1,2012
DNA Damageother cell types/human80 µmol/L/2HMUREAV 747,1,2012
DNA Damageother cell types/human80 µmol/L/24HMUREAV 747,1,2012
DNA inhibitionHeLa cell/human4400 µmol/LMUREAV 93,447,1982
DNA repair/Escherichia coli5 µg/wellMUREAV 133,161,1984
DNA repairlymphocyte/human200 µmol/L/24HMUTAEX 16,127,2001
gene conversion and mitotic recombination/Schizosaccharomyces pombe20 mmol/LCOINAV 256,315,1977
gene conversion and mitotic recombination/Saccharomyes cerevisiae20 mmol/LMUREAV 40,317,1976
host-mediated assaySaccharomyes cerevisiae/mouse100 mg/kgMUREAV 40,317,1976
host-mediated assaySchizosaccharomyces pombe/mouse100 mg/kgMUREAV 40,317,1976
micronucleus testleukocyte/human100 µmol/L/30MMUREAV 491,163,2001
micronucleus testleukocyte/human0.05 mmol/L/40HMUREAV 536,49,2003
micronucleus testleukocyte/human0.3 mmol/L/1HMUTAEX 22,209,2007
morphological transformfibroblast/mouse30 mg/L/10DMUREAV 702,100,2010
mutation in mammalian somatic cellsfibroblast/hamster17 mmol/L/60MMUREAV 40,317,1976
mutation in mammalian somatic cellslung/hamster2080 µmol/L/2HCBINA8 39,57,1982
mutation in mammalian somatic cellslymphocyte/mouse13800 µg/LMUREAV 97,49,1982
mutation in microorganisms/Schizosaccharomyces pombe10 mmol/L (-enzymatic activation step)COINAV 256,315,1977
mutation in microorganisms/Schizosaccharomyces pombe5 mmol/L (+enzymatic activation step)MUREAV 40,317,1976
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)JOPHDQ 1,301,1978
mutation in microorganisms/Salmonella typhimurium500 µg/plate (-enzymatic activation step)PNASA6 72,5135,1975
mutation in microorganisms/Escherichia coli2 mmol/L (-enzymatic activation step)CMSHAF 7,737,1978
mutation in microorganisms/Bacillus subtilis5 mmol/L (-enzymatic activation step)MSERDS 5,131,1981
mutation in microorganisms/Klebsiella pneumoniae500 µmol/L (-enzymatic activation step)MUREAV 89,269,1981
other mutation test systemsfibroblast/mouse1 µmol/LCRNGDP 6,1367,1985
other mutation test systems/Escherichia coli300 µmol/LMUREAV 231,205,1990
other mutation test systems/Salmonella typhimurium70 µg/LMUREAV 192,239,1987
sister chromatid exchangeinhalation/mouse50 ppm/5H-continuousEVSRBT 25,433,1982
sister chromatid exchangelymphocyte/human100 µmol/LCRNGDP 1,357,1980
sister chromatid exchangeintraperitoneal/hamster500 mg/kgCBINA8 26,305,1979
sister chromatid exchangeovary/hamster25 mg/LCBINA8 20,163,1978
sister chromatid exchangelung/hamster100 mg/LCNREA8 44,3270,1984
sister chromatid exchangeleukocyte/human50 µmol/L/30MMUREAV 491,163,2001
sister chromatid exchangelymphocyte/rat60 mg/L/72HMUREAV 472,85,2000
specific locus testother cell types/human1.25 mmol/L/1HEMMUEG 37,285,2001
Unscheduled DNA Synthesislymphocyte/human100 µmol/LMUREAV 395,37,1997
Unscheduled DNA Synthesisother cell types/human4400 µmol/LFCTXAV 18,434,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 100 ppm/7H (1-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
SWEHDO 7(Suppl 4),66,1981
inhalation/rat 100 ppm/7H (1-19D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB81-168510
inhalation/rat 100 ppm/7H (1-19D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
SWEHDO 9,94,1983
inhalation/rabbit 15 ppm/7H (1-24D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)NTIS** PB81-168510

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 273 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
JJIND8 77,471,1986
oral/rat lowest published toxic dose: 65 gm/kg/52W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
ANYAA9 534,203,1988
oral/rat lowest published toxic dose: 10 gm/kg/52W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
MELAAD 70,358,1979
oral/rat toxic dose: 52 gm/kg/52W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
MELAAD 70,358,1979
oral/rat toxic dose: 200 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
JJIND8 77,471,1986
skin/mouse lowest published toxic dose: 74 gm/kg/62W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
JNCIAM 31,41,1963
unreported route/mouse lowest published toxic dose: 96 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
RARSAM 3,193,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 500 ppm/4HAMIHBC 10,61,1954
intraperitoneal/mouse lowest published toxic dose: 300 mg/kgLung, Thorax, or Respiration: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 150,335,2004
intraperitoneal/mouse lowest published toxic dose: 300 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 227,165,2006
intraperitoneal/mouse lowest published toxic dose: 300 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesTOXID9 227,217,2006
intraperitoneal/mouse lowest published toxic dose: 300 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOLED5 183,28,2008
intraperitoneal/rat lethal dose (50 percent kill): 460 mg/kgTXAPA9 18,321,1971
oral/guinea pig lethal dose (50 percent kill): 2 gm/kgNTIS** PB81-168510
oral/mouse lethal dose (50 percent kill): 1500 mg/kgJJIND8 77,471,1986
oral/rat lethal dose (50 percent kill): 2 gm/kgNTIS** PB81-168510
skin/rabbit lethal dose (50 percent kill): 890 µL/kgUCDS** 7/21/1977
unreported route/mouse lowest published toxic dose: 300 mg/kgLung, Thorax, or Respiration: Other changesTOXID9 -,194,2009

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 8400 mg/kg/7W- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
JTSCDR 14,1,1989
intraperitoneal/rat lowest published toxic dose: 350 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
BECTA6 34,722,1985

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 36,245,1985
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 60,321,1994
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 36,245,1985
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 60,321,1994
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 60,321,1994
TOXICOLOGY REVIEWTOLED5 138,75,2003
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUREAV 544,339,2003
TOXICOLOGY REVIEWMUREAV 672,10,2009
TOXICOLOGY REVIEWMUREAV 672,17,2009
TOXICOLOGY REVIEWMUREAV 678,76,2009
TOXICOLOGY REVIEWMUREAV 752,99,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2A carc, MAY2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84819; Number of Industries 2; Total Number of Facilities 109; Number of Occupations 4; Total Number of Employees Exposed 458
National Occupational Hazard Survey 1974Hazard Code 84819; Number of Industries 2; Total Number of Facilities 59; Number of Occupations 5; Total Number of Employees Exposed 1740

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: In vitro human lymphocyte micronucleus
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Weakly Positive: S pombe-forward mutation
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis Studies (gavage);clear evidence:mouse,ratJJIND8 77,471,1986
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