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Benzene, p - dimethoxy -

RTECS #: CZ6650000

CAS #: 150-78-7


UPDATE: May 2009 MW: 138.18 MF: C8H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1,4 - Dimethoxybenzene
  2. Anisole, p - methoxy -
  3. Benzene, 1,4 - dimethoxy -
  4. DMB
  5. Dimethylether hydrochinonu (Czech)
  6. Dimethyl ether hydroquinone
  7. Dimethylhydroquinone
  1. Dimethylhydroquinone ether
  2. Hydroquinone, dimethyl ether
  3. Quinol dimethyl ether
  4. USAF AN - 9
  5. USAF uctl - 1791
  6. p - Dimethoxybenzene
  7. p - Methoxyanisole


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
guinea pig
40%/24 hour moderate FCTXAV 16,715,1978
skin
rabbit
6 gm/12 day- intermittent mild JIHTAB 31,79,1949
skin
rabbit
500 mg/24 hour moderate FCTXAV 16,715,1978


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TPKVAL 4,108,1962
oral
mouse
lethal dose (50 percent kill): 4 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity
GTPZAB 4(2),30,1960
oral
mouse
lethal dose (50 percent kill): 2,300 mg/kg Behavioral: Muscle contraction or spasticity

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,295,1994
oral
mouse
lowest published lethal dose: 2,750 mg/kg N/R TPKVAL 4,108,1962
oral
mouse
lethal dose (50 percent kill): 3,762.5 mg/kg N/R TPKVAL 4,108,1962
oral
mouse
lowest published toxic dose: 2,500 mg/kg Behavioral: General anesthetic

Vascular: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 4,108,1962
oral
rat
lethal dose (50 percent kill): 3,600 mg/kg N/R FCTXAV 16,715,1978
oral
rat
lowest published toxic dose: 500 mg/kg Cardiac: EKG changes not diagnostic of above

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,295,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2701;
Number of Industries 31;
Total Number of Facilities 3,010;
Number of Occupations 27;
Total Number of Employees Exposed 24,385;
Total Number of Female Employees Exposed 5,739


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HUTOX*
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Drug
   Primary Irritant

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