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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, p-dimethoxy-

RTECS #

CZ6650000

CAS #

150-78-7

Updated

May 2009

Molecular Weight

138.18

Molecular Formula

C8H10O2

Synonyms

1,4-Dimethoxybenzene
Anisole, p-methoxy-
Benzene, 1,4-dimethoxy-
Dimethyl ether hydroquinone
Dimethylether hydrochinonu (Czech)
Dimethylhydroquinone
Dimethylhydroquinone ether
DMB
Hydroquinone, dimethyl ether
p-Dimethoxybenzene
p-Methoxyanisole
Quinol dimethyl ether
USAF AN-9
USAF uctl-1791

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /guinea pig 40%/24H moderateFCTXAV 16,715,1978
skin /rabbit 6 gm/12D- intermittent mildJIHTAB 31,79,1949
skin /rabbit 500 mg/24H moderateFCTXAV 16,715,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 100 mg/kgNTIS** AD277-689
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritationTPKVAL 4,108,1962
oral/mouse lowest published lethal dose: 2750 mg/kgTPKVAL 4,108,1962
oral/mouse lethal dose (50 percent kill): 3762.5 mg/kgTPKVAL 4,108,1962
oral/mouse lowest published toxic dose: 2500 mg/kgBehavioral: General anesthetic

Vascular: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 4,108,1962
oral/mouse lethal dose (50 percent kill): 2300 mg/kgBehavioral: Muscle contraction or spasticity

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,295,1994
oral/mouse lethal dose (50 percent kill): 4 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity
GTPZAB 4(2),30,1960
oral/rat lethal dose (50 percent kill): 3600 mg/kgFCTXAV 16,715,1978
oral/rat lowest published toxic dose: 500 mg/kgCardiac: EKG changes not diagnostic of above

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,295,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHUTOX* -,577,1996

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X2701; Number of Industries 31; Total Number of Facilities 3010; Number of Occupations 27; Total Number of Employees Exposed 24385; Total Number of Female Employees Exposed 5739

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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