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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, diisopropyl-

RTECS #

CZ6330000

CAS #

25321-09-9

Updated

January 2010

Molecular Weight

162.30

Molecular Formula

C12H18

Synonyms

Benzene, bis(1-methylethyl)- (9CI)
Bis(1-methylethyl)benzene
Diisopropylbenzene

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,39,1986
skin /rabbit 100 mg/24H moderate85JCAE -,39,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 5300 mg/m3/2H85GMAT -,54,1982
inhalation/rat Lowest published lethal concentration: 5300 mg/m3/4H85GMAT -,54,1982
oral/rat lethal dose (50 percent kill): 6500 µL/kgTXAPA9 28,313,1974
oral/rat lethal dose (50 percent kill): 3900 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis

Blood: Hemorrhage
HPV207 -,-,2002
skin/rabbit lethal dose (50 percent kill): 16 mL/kgTXAPA9 28,313,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 4200 mg/kg/28D- intermittentEye: Mydriasis (pupilliary dilation)HPV207 -,-,2002
oral/rat lowest published toxic dose: 21000 mg/kg/28D- intermittentEye: Mydriasis (pupilliary dilation)

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
HPV207 -,-,2002

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 50 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9241
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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