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Benzene, 2,6 - diisocyanato - 1 - methyl -

RTECS #: CZ6310000

CAS #: 91-08-7


UPDATE: May 2009 MW: 174.17 MF: C9H6N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2,6 - Diisocyanato - 1 - methylbenzene
  2. 2,6 - Diisocyanatotoluene
  3. 2,6 - TDI
  4. 2,6 - Toluene diisocyanate
  5. 2 - Methyl - meta - phenylene diisocyanate
  1. 2 - Methyl - meta - phenylene isocyanate
  2. Isocyanic acid, 2 - methyl - meta - phenylene ester
  3. Toluene 2,6 - diisocyanate
  4. Tolylene 2,6 - diisocyanate
  5. meta - Tolylene diisocyanate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 600 mg/L EMMUEG 13,133,1989
mutation in microorganisms Salmonella typhimurium 10 g/plate (-enzymatic activation step) NTPTR* NTP-TR-251,1986
mutation in microorganisms Salmonella typhimurium 300 g/plate (+enzymatic activation step) MUREAV 438,109,1999
morphological transform mouse fibroblast 20 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
sister chromatid exchange hamster ovary 300 mg/L EMMUEG 13,133,1989
specific locus test mouse lymphocyte 25 mg/L EMMUEG 17,196,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 50 ppb Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes
ATXKA8 19,364,1962
oral
wild bird
lethal dose (50 percent kill): 100 mg/kg N/R AECTCV 12,355,1983


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.005 ppm;short term exposure limit 0.02 ppm (sen) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 39,287,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,865,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,287,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,865,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,865,1999
TOXICOLOGY REVIEW
MUREAV 681,93,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, JUL2008
Occupational Exposure Limit - AUSTRIA MAK 0.035 mg/m3 (0.005 ppm), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.005 ppm (0.037 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.02 ppm (0.14 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 ppm (0.035 mg/m3), OCT 2002
Occupational Exposure Limit - HUNGARY ceiling concentration 0.035 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.005 ppm (0.035 mg/m3), 2B carcinogen, sen, APR2007
Occupational Exposure Limit - JAPAN Occupational Exposure Limit- continuous 0.02 ppm (0.14 mg/m3), APR2007
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.04 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.005 ppm (0.035 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.035 mg/m3, MAC(short term exposure limit) 0.070 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.002 ppm (0.014 mg/m3), Carcinogen, Sen, JUN2005
Occupational Exposure Limit - SWEDEN ceiling concentration 0.005 ppm (0.04 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.005 ppm (0.02 mg/m3),KZG- week 0.005 ppm (0.02 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0788;
Number of Industries 14;
Total Number of Facilities 609;
Number of Occupations 18;
Total Number of Employees Exposed 15,830
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0788;
Number of Industries 12;
Total Number of Facilities 415;
Number of Occupations 22;
Total Number of Employees Exposed 2,872;
Total Number of Female Employees Exposed 284


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of POLYURETHANE flexible foams, coatings, and elastomers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #42


REFERENCES:

CODEN
REFERENCE

AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

Used in the production of POLYURETHANE flexible foams, coatings, and elastomers

NIOSH PROFILE (ISOCYANATES, ORGANIC), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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