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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, 2,6-diisocyanato-1-methyl-

RTECS #

CZ6310000

CAS #

91-08-7

Updated

September 201

Molecular Weight

174.17

Molecular Formula

C9H6N2O2

Synonyms

2,6-Diisocyanato-1-methylbenzene
2,6-Diisocyanatotoluene
2,6-TDI
2,6-Toluene diisocyanate
2-Methyl-meta-phenylene diisocyanate
2-Methyl-meta-phenylene isocyanate
Isocyanic acid, 2-methyl-meta-phenylene ester
meta-Tolylene diisocyanate
Toluene 2,6-diisocyanate
Tolylene 2,6-diisocyanate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster600 mg/LEMMUEG 13,133,1989
morphological transformfibroblast/mouse20 mg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)NTPTR* NTP-TR-251,1986
mutation in microorganisms/Salmonella typhimurium300 µg/plate (+enzymatic activation step)MUREAV 438,109,1999
sister chromatid exchangeovary/hamster300 mg/LEMMUEG 13,133,1989
specific locus testlymphocyte/mouse25 mg/LEMMUEG 17,196,1991

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 50 ppbOlfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes
ATXKA8 19,364,1962
oral/wild bird lethal dose (50 percent kill): 100 mg/kgAECTCV 12,355,1983

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 7.5 mg/m3/3D- intermittentImmunological Including Allergic: Increased immune response

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 261,103,2009

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.005 ppm;short term exposure limit 0.02 ppm (sen)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 39,287,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,865,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 39,287,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 71,865,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,865,1999
TOXICOLOGY REVIEWMUREAV 681,93,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.005 ppm (0.035 mg/m3);KZW 0.02 ppm (0.14 mg/m3), sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.005 ppm (0.037 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.02 ppm (0.14 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.005 ppm (0.035 mg/m3), carc, MAY2011
Occupational Exposure Limit-HUNGARYceiling concentration 0.035 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.005 ppm (0.04 mg/m3), short term exposure limit 0.01 ppm (0.07 mg/m3), sen, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.005 ppm, skin, 2B carc, s1 sen, MAY2012
Occupational Exposure Limit-JAPANceiling concentration 0.02 ppm (0.14 mg/m3), MAY2012
Occupational Exposure Limit-NORWAYtime-weighted average 0.005 ppm (0.035 mg/m3), JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.035 mg/m3, MAC(short term exposure limit) 0.070 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.002 ppm (0.014 mg/m3), Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWEDENceiling concentration 0.005 ppm (0.04 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.02 mg(NCO)/m3, skin, sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.04 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0788; Number of Industries 12; Total Number of Facilities 415; Number of Occupations 22; Total Number of Employees Exposed 2872; Total Number of Female Employees Exposed 284
National Occupational Hazard Survey 1974Hazard Code M0788; Number of Industries 14; Total Number of Facilities 609; Number of Occupations 18; Total Number of Employees Exposed 15830

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #42
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