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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, diethyl-

RTECS #

CZ5600000

CAS #

25340-17-4

Updated

January 2010

Molecular Weight

134.24

Molecular Formula

C10H14

Synonyms

Diethylbenzene
Diethylbenzol
MCS-2313

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 88 mg mildAMIHAB 14,387,1956
skin /rabbit 100% moderateAMIHAB 14,387,1956

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1000 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleHPV201 -,-,2001
oral/rat 2000 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV201 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 3 gm/m3Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement
GTPZAB 9(12),19,1965
inhalation/rat Lowest published lethal concentration: 3 gm/m3Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement
GTPZAB 9(12),19,1965
intravenous/mammal (species unspecified) lowest published lethal dose: 317 µg/kgAPJUA8 24,179,1974
oral/mammal (species unspecified) lethal dose (50 percent kill): 6200 mg/kgGISAAA 39(4),86,1974
oral/rabbit lethal dose (50 percent kill): 3 gm/kgGISAAA 40(6),90,1975
oral/rat lowest published lethal dose: 5 gm/kg28ZRAQ -,57,1960
oral/rat lethal dose (50 percent kill): 2050 mg/kgGastrointestinal: Gastritis

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder
HPV201 -,-,2001
oral/rat lethal dose (50 percent kill): 4700 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
HPV201 -,-,2001
skin/rabbit lethal dose (50 percent kill): >5000 mg/kgBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV201 -,-,2001
skin/rat lethal dose (50 percent kill): >2000 mg/kgSkin: After topical application: Primary irritationHPV201 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 680 ppm/6H/18W- intermittentPeripheral Nerve and Sensation: Recording from afferent nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
JJATDK 12,335,1992
inhalation/rat lowest published toxic concentration: 50 mg/m3/22W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 9(12),19,1965
inhalation/rat lowest published toxic concentration: 1200 mg/m3/10W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV201 -,-,2001
oral/rabbit lowest published toxic dose: 27 mg/kg/6W- intermittentVascular: Regional or general arteriolar or venous dilation

Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA 40(6),90,1975

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-POLANDtime-weighted average 100 mg/m3, short term exposure limit 400 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X3692; Number of Industries 3; Total Number of Facilities 18; Number of Occupations 10; Total Number of Employees Exposed 142; Total Number of Female Employees Exposed 3

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8828
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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