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Benzene, 1,4 - dichloro - 2 - nitro -

RTECS #: CZ5260000

CAS #: 89-61-2


UPDATE: May 2003 MW: 192.00 MF: C6H3Cl2NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,4 - Dichloro - 2 - nitrobenzene
  2. 2,5 - Dichlornitrobenzen (Czech)
  1. 2,5 - Dichloronitrobenzene
  2. Nitro - p - dichlorobenzene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 85JCAE -,601,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,601,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 10 mmol/L/48 hour (-enzymatic activation step) MUREAV 517,187,2002
mutation in microorganisms Salmonella typhimurium 205 g/plate (+enzymatic activation step) MUREAV 116,217,1983
mutation in microorganisms Salmonella typhimurium 250 g/plate (-enzymatic activation step) SAIGBL 29,34,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 7 gm/kg (28 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
BFUUA* 65,1,1991


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
cat
lowest published toxic dose: 250 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia BFUUA* 65,1,1991
oral
guinea pig
lethal dose (50 percent kill): 800 mg/kg N/R NTIS** OTS0536149
oral
mouse
lethal dose (50 percent kill): 2,850 mg/kg N/R GTPZAB 25(8),50,1981
oral
rat
lethal dose (50 percent kill): 1 gm/kg N/R CHYCDW 21,315,1987
oral
rat
lethal dose (50 percent kill): 1,210 mg/kg Ear: Changes in vestibular functions

Behavioral: Muscle contraction or spasticity
BFUUA* 65,1,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lowest published toxic dose: 7,000 mg/kg/28 day- intermittent Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Changes in testicular weight
BFUUA* 65,1,1991
intramuscular
rat
lowest published toxic dose: 1,400 mg/kg/28 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
BFUUA* 65,1,1991
intramuscular
rabbit
lowest published toxic dose: 700 mg/kg/1 week- intermittent Blood: Changes in spleen

Blood: Changes in erythrocyte (RBC) count
BFUUA* 65,1,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BFUUA* Beratergremium fuer umweltrelevante Altstoffe (BUA. Gesellschaft Deutscher Chemiker. Weinheim ; New York : VCH) 1992-
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

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