Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, 1,4-dichloro-2-nitro-

RTECS #

CZ5260000

CAS #

89-61-2

Updated

May 2003

Molecular Weight

192.00

Molecular Formula

C6H3Cl2NO2

Synonyms

1,4-Dichloro-2-nitrobenzene
2,5-Dichlornitrobenzen (Czech)
2,5-Dichloronitrobenzene
Nitro-p-dichlorobenzene

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate85JCAE -,601,1986
skin /rabbit 500 mg/24H mild85JCAE -,601,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster10 mmol/L/48H (-enzymatic activation step)MUREAV 517,187,2002
mutation in microorganisms/Salmonella typhimurium205 µg/plate (+enzymatic activation step)MUREAV 116,217,1983
mutation in microorganisms/Salmonella typhimurium250 µg/plate (-enzymatic activation step)SAIGBL 29,34,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 7 gm/kg (28D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
BFUUA* 65,1,1991

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/cat lowest published toxic dose: 250 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaBFUUA* 65,1,1991
oral/guinea pig lethal dose (50 percent kill): 800 mg/kgNTIS** OTS0536149
oral/mouse lethal dose (50 percent kill): 2850 mg/kgGTPZAB 25(8),50,1981
oral/rat lethal dose (50 percent kill): 1 gm/kgCHYCDW 21,315,1987
oral/rat lethal dose (50 percent kill): 1210 mg/kgEar: Changes in vestibular functions

Behavioral: Muscle contraction or spasticity
BFUUA* 65,1,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intramuscular/rabbit lowest published toxic dose: 700 mg/kg/1W- intermittentBlood: Changes in spleen

Blood: Changes in erythrocyte (RBC) count
BFUUA* 65,1,1991
intramuscular/rat lowest published toxic dose: 7000 mg/kg/28D- intermittentLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Changes in testicular weight
BFUUA* 65,1,1991
intramuscular/rat lowest published toxic dose: 1400 mg/kg/28D- intermittentGastrointestinal: Ulceration or bleeding from stomach

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
BFUUA* 65,1,1991

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP