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Benzene, 1,2 - dichloro - 4 - nitro -

RTECS #: CZ5250000

CAS #: 99-54-7


UPDATE: February 2009 MW: 192.00 MF: C6H3Cl2NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2 - Dichloro - 4 - nitrobenzene
  2. 3,4 - Dichlornitrobenzen (Czech)
  3. 3,4 - Dichloronitrobenzene
  1. DCNB
  2. Nitrated orthene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 85JCAE -,601,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,601,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 250 g/plate (+/-enzymatic activation step) SAIGBL 29,34,1987
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
200 ppm ENMUDM 7,677,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,500 mg/kg (6-12 day pregnant) Reproductive: Other effects on female NTIS** OTS0534376


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 10 gm/m3/4 hour Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0533734
intraperitoneal
mouse
lethal dose (50 percent kill): 400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression
NTIS** OTS0533585
intraperitoneal
rat
lethal dose (50 percent kill): 400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Cyanosis
NTIS** OTS0533585
oral
guinea pig
lethal dose (50 percent kill): 500 mg/kg N/R NTIS** OTS0536149
oral
mouse
lethal dose (50 percent kill): 1,384 mg/kg N/R 85GMAT -,47,1982
oral
mouse
lowest published toxic dose: 500 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 -,45,2008
oral
rat
lethal dose (50 percent kill): 953 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0533734
skin
cat
lethal dose (50 percent kill): 790 mg/kg N/R 85GMAT -,47,1982
skin
rabbit
lethal dose : >200 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0533734


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 28 mg/m3/4 hour/21 day- intermittent Blood: Eosinophilia

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 34(11),26,1969
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/17 week- intermittent Blood: Thrombocytopenia

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 34(11),26,1969
oral
mouse
lowest published toxic dose: 2,100 mg/kg/14 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 -,45,2008
oral
mouse
lowest published toxic dose: 2,100 mg/kg/14 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in spleen

Blood: Changes in other cell count (unspecified)
TOXID9 -,45,2008
oral
rat
lowest published toxic dose: 4,200 mg/kg/4 week- continuous Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0534360


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as dye and pesticide intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9189
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as dye and pesticide intermediate

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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