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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, (dichloromethyl)-

RTECS #

CZ5075000

CAS #

98-87-3

Updated

July 2013

Molecular Weight

161.03

Molecular Formula

C7H6Cl2

Synonyms

(Dichloromethyl)benzene
alpha,alpha-Dichlorotoluene
Benzal chloride
Benzyl dichloride
Benzylene chloride
Chlorobenzal
Chlorure de benzylidene (French)
RCRA waste number U017
Toluene, alpha,alpha-dichloro-

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Bacillus subtilis31 µmol/discMUREAV 58,143,1978
mutation in microorganisms/Salmonella typhimurium600 nmol/plate/20M (-enzymatic activation step)MUREAV 58,143,1978
mutation in microorganisms/Escherichia coli600 nmol/plate/20M (+enzymatic activation step)MUREAV 58,143,1978

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 9200 mg/kg/50W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
GANNA2 72,655,1981
skin/mouse toxic dose: 35200 mg/kg/42W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
GANNA2 72,655,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 210 mg/m3GTPZAB 30(3),6,1986
inhalation/mouse lethal concentration (50 percent kill): 210 mg/m3Behavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,41,1984
inhalation/mouse lethal concentration (50 percent kill): 32 ppm/2HBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression
IMEMDT 29,65,1982
inhalation/mouse lethal concentration (50 percent kill): 0.21 gm/m3TPKVAL 9,27,1967
inhalation/rat lethal concentration (50 percent kill): 0.4 gm/m3TPKVAL 9,27,1967
inhalation/rat lethal concentration (50 percent kill): 61 ppm/2HBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression
IMEMDT 29,65,1982
inhalation/rat lethal concentration (50 percent kill): 400 mg/m3Behavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,41,1984
oral/mammal (species unspecified) lethal dose (50 percent kill): 1400 mg/kgGISAAA 40(1),92,1975
oral/mouse lethal dose (50 percent kill): 2462 mg/kgAMRL** TR-72-62,1972
oral/mouse lethal dose (50 percent kill): 1400 mg/kgBehavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,41,1984
oral/rat lethal dose (50 percent kill): 1400 mg/kgBehavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,41,1984
oral/rat lethal dose (50 percent kill): 3249 mg/kgAMRL** TR-72-62,1972

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 29,65,1982
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,453,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 71,453,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 29,65,1982

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIATRK-TMW 0.015 ppm (0.1 mg/m3);KZW 0.06 ppm (0.4 mg/m3), 2007
Occupational Exposure Limit-JAPAN2A carc, MAY2012
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.015 ppm (0.1 mg/m3), carc 3, skin, JAN2011

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; Histidine reversion-Ames test
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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