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Benzene, (dichloromethyl) -

RTECS #: CZ5075000

CAS #: 98-87-3


UPDATE: May 2008 MW: 161.03 MF: C7H6Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. (Dichloromethyl) benzene
  2. Benzal chloride
  3. Benzyl dichloride
  4. Benzylene chloride
  5. Chlorobenzal
  1. Chlorure de benzylidene (French)
  2. RCRA waste number U017
  3. Toluene, alpha,alpha - dichloro -
  4. alpha,alpha - Dichlorotoluene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA repair Bacillus subtilis 31 Ámol/disc MUREAV 58,143,1978
mutation in microorganisms Escherichia coli 600 nmol/plate/20 minute (+enzymatic activation step) MUREAV 58,143,1978
mutation in microorganisms Salmonella typhimurium 600 nmol/plate/20 minute (-enzymatic activation step) MUREAV 58,143,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 9,200 mg/kg/50 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
GANNA2 72,655,1981
skin
mouse
toxic dose : 35,200 mg/kg/42 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
GANNA2 72,655,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 210 mg/m3 N/R GTPZAB 30(3),6,1986
inhalation
mouse
lethal concentration (50 percent kill): 32 ppm/2 hour Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression
IMEMDT 29,65,1982
inhalation
mouse
lethal concentration (50 percent kill): 210 mg/m3 Behavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,41,1984
inhalation
mouse
lethal concentration (50 percent kill): 0.21 gm/m3 N/R TPKVAL 9,27,1967
inhalation
rat
lethal concentration (50 percent kill): 61 ppm/2 hour Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression
IMEMDT 29,65,1982
inhalation
rat
lethal concentration (50 percent kill): 400 mg/m3 Behavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,41,1984
inhalation
rat
lethal concentration (50 percent kill): 0.4 gm/m3 N/R TPKVAL 9,27,1967
oral
mammal (species unspecified)
lethal dose (50 percent kill): 1,400 mg/kg N/R GISAAA 40(1),92,1975
oral
mouse
lethal dose (50 percent kill): 2,462 mg/kg N/R AMRL** TR-72-62,1972
oral
mouse
lethal dose (50 percent kill): 1,400 mg/kg Behavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,41,1984
oral
rat
lethal dose (50 percent kill): 3,249 mg/kg N/R AMRL** TR-72-62,1972
oral
rat
lethal dose (50 percent kill): 1,400 mg/kg Behavioral: General anesthetic

Lung, Thorax, or Respiration: Cough
VCVGK* -,41,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 29,65,1982
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,453,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 71,453,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 29,65,1982


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA TRK 0.1 mg/m3 (0.015 mL/m3), JAN 2006
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN Group B Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.015 ppm (0.1 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in the manufacture of BENZALDEHYDE and CINNAMIC ACID
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in the manufacture of BENZALDEHYDE and CINNAMIC ACID

RTECS Compound Description:
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

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