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Benzene, m - dichloro -

RTECS #: CZ4499000

CAS #: 541-73-1


UPDATE: February 2009 MW: 147.00 MF: C6H4Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,3 - Dichlorobenzene
  2. Benzene, 1,3 - dichloro - (9CI)
  3. RCRA waste number U071
  1. m - Dichlorobenzene
  2. m - Dichlorobenzol
  3. m - Phenylenedichloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
micronucleus test intraperitoneal
mouse
175 mg/kg/24 hour MUTAEX 2,111,1987
gene conversion and mitotic recombination Saccharomyes cerevisiae 5 ppm NTIS** PB84-138973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 1,062 mg/kg N/R MUTAEX 2,111,1987
oral
rat
lowest published toxic dose: 200 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
VCVGK* -,24,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,470 mg/kg/10 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Changes in: Ca

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
DCTODJ 18,201,1995
oral
rat
lowest published toxic dose: 3,330 mg/kg/90 day- intermittent Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
DCTODJ 18,201,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 73,223,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,223,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 73,223,1999
TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
ENTOX* -,5,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA MAK 20 mg/m3 (3 ppm), JAN 2006
Occupational Exposure Limit - HUNGARY time-weighted average 20 mg/m3, short term exposure limit 80 mg/m3, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2135;
Number of Industries 2;
Total Number of Facilities 49;
Number of Occupations 3;
Total Number of Employees Exposed 418;
Total Number of Female Employees Exposed 80


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Tumorigen
   Mutagen

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