Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, m-dichloro-

RTECS #

CZ4499000

CAS #

541-73-1

Updated

July 2013

Molecular Weight

147.00

Molecular Formula

C6H4Cl2

Synonyms

1,3-Dichlorobenzene
Benzene, 1,3-dichloro- (9CI)
m-Dichlorobenzene
m-Dichlorobenzol
m-Phenylenedichloride
RCRA waste number U071

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
gene conversion and mitotic recombination/Saccharomyes cerevisiae5 ppmNTIS** PB84-138973
micronucleus testintraperitoneal/mouse175 mg/kg/24HMUTAEX 2,111,1987
micronucleus testintraperitoneal/mouse175 mg/kgHPV173 -,-,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 1062 mg/kgMUTAEX 2,111,1987
oral/rat lowest published toxic dose: 200 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
VCVGK* -,24,1984
oral/rat lethal dose (50 percent kill): 1100 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
HPV173 -,-,2002
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgHPV173 -,-,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1470 mg/kg/10D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Changes in: Ca

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
DCTODJ 18,201,1995
oral/rat lowest published toxic dose: 3330 mg/kg/90D- intermittentEndocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
DCTODJ 18,201,1995
oral/rat lowest published toxic dose: 13230 mg/kg/90D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
HPV173 -,-,2002
oral/rat lowest published toxic dose: 52920 mg/kg/90D- intermittentRelated to Chronic Data: Changes in testicular weightHPV173 -,-,2002

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 73,223,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 73,223,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 73,223,1999
TOXICOLOGY REVIEWTOLED5 127,111,2002
TOXICOLOGY REVIEWENTOX* -,5,2005
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 3 ppm (20 mg/m3);KZW 12 ppm (80 mg/m3), skin, 2007
Occupational Exposure Limit-GERMANYMAK 2 ppm (12 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 20 mg/m3, short term exposure limit 80 mg/m3, SEP2000
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (12 mg/m3), KZG-week 4 ppm (24 mg/m3), JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X2135; Number of Industries 2; Total Number of Facilities 49; Number of Occupations 3; Total Number of Employees Exposed 418; Total Number of Female Employees Exposed 80

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
TOP