Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

1,2-Benzenedicarboxylic acid, di-2-propenyl ester

RTECS #

CZ4200000

CAS #

131-17-9

Updated

July 2013

Molecular Weight

246.28

Molecular Formula

C14H14O4

Synonyms

Dapon 35
Dapon R
Diallyl phthalate
Diallylester kyseliny ftalove (Czech)
Diallylphthalate
NCI-C50657
o-Phthalic acid, diallyl ester
Phthalic acid, diallyl ester

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg mildAJOPAA 29,1363,1946
skin /rabbit 500 mg moderateNTIS** OTS0521089

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/mouse300 mg/kgEMMUEG 25,302,1995
Cytogenetic Analysisovary/hamster200 mg/LSCIEAS 236,933,1987
mutation in mammalian somatic cellslymphocyte/mouse67200 µg/LSCIEAS 236,933,1987
mutation in microorganismslymphocyte/mouse67200 µg/L (+enzymatic activation step)SCIEAS 236,933,1987
sister chromatid exchangeovary/hamster160 mg/LSCIEAS 236,933,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 3000 mg/kg (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FCTOD7 46,2150,2008

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 156 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
EVHPAZ 65,271,1986
oral/mouse lowest published toxic dose: 154500 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Blood: Lymphoma including Hodgkin's disease
NTIS** PB83-200824
oral/mouse lowest published toxic dose: 154500 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB83-200824
oral/rat lowest published toxic dose: 51500 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB86-203742/AS
oral/rat lowest published toxic dose: 52 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
EVHPAZ 65,271,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 110.3 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
inhalation/rat lethal concentration (50 percent kill): 5200 mg/m3/1HEye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0521092
oral/Dog lowest published lethal dose: 800 mg/kgNTIS** OTS0521092
oral/mouse lowest published lethal dose: 681 mg/kgNTPTR* NTP-TR-242,1983
oral/rabbit lethal dose (50 percent kill): 1700 mg/kg14CYAT 2,1904,1963
oral/rat lethal dose (50 percent kill): 656 mg/kgBehavioral: Somnolence (general depressed activity)NTPTR* NTP-TR-284,1985
skin/rabbit lethal dose (50 percent kill): 3300 mg/kgNTIS** OTS0521092
subcutaneous/rabbit lowest published lethal dose: 1 gm/kgLung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), diffuse
FEPRA7 5,191,1946

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 5600 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-242,1983
oral/rat lowest published toxic dose: 750 mg/kg/3D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 46,2150,2008
oral/rat lowest published toxic dose: 3000 mg/kg/15D- intermittentBehavioral: Food intake (animal)

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 46,2150,2008
oral/rat lowest published toxic dose: 2250 mg/kg/15D- intermittentLiver: Other changesFCTOD7 46,2150,2008
oral/rat lowest published toxic dose: 5600 mg/kg/14D- intermittentLung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-284,1985
oral/rat lowest published toxic dose: 26 gm/kg/13W- intermittentLiver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-284,1985

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWRREVAH 54,1,1975
TOXICOLOGY REVIEWEVHPAZ 4,3,1973
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWCRTXB2 36,695,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUTAEX 26,205,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 mg/m3, 2007
Occupational Exposure Limit-DENMARKtime-weighted average 3 mg/m3, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 3 mg/m3, NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-RUSSIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 23180; Number of Industries 11; Total Number of Facilities 484; Number of Occupations 18; Total Number of Employees Exposed 8784; Total Number of Female Employees Exposed 2027
National Occupational Hazard Survey 1974Hazard Code 23180; Number of Industries 15; Total Number of Facilities 390; Number of Occupations 27; Total Number of Employees Exposed 8596

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse,rat
NTP Carcinogenesis Studies (gavage);inadequate studies:mouse,rat NTPTR* NTP-TR-242,1983
TOP