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Registry of Toxic Effects of Chemical Substances (RTECS)

1,2-Benzenedicarboxylic acid, diisononyl ester

RTECS #

CZ3850000

CAS #

28553-12-0; 41375-91-1; 105009-97-0

Updated

April 2012

Molecular Weight

418.68

Molecular Formula

C26H42O4

Synonyms

Baylectrol 4200
Diisononyl phthalate
DINP
DINP2
DINP3
ENJ 2065
Isononyl alcohol, phthalate (2:1)
Jayflex DINP
Palatinol DN
Palatinol N
Phthalic acid, diisononyl ester
Phthalisocizer DINP
Sansocizer DINP
Vestinol NN
Vinylcizer 90
Witamol 150

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 10 gm/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FCTOD7 35,501,1997
oral/rat 18 gm/kg (15-21D preg/10D after birth)Reproductive: Specific developmental abnormalities: Endocrine systemTOXID9 72,77,2003
oral/rat 11.25 gm/kg (7-21D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemREPTED 17,475,2003
oral/rat 17.4 gm/kg (7-22D preg/1-13D after birth)Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Other postnatal measures or effects
REPTED 17,475,2003
oral/rat 10.2 gm/kg (7-22D preg/1D after birth)Reproductive: Effects on newborn: Other postnatal measures or effectsREPTED 17,475,2003
oral/rat 400 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)REPTED 16,679,2002
oral/rat 10 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 16,679,2002
oral/rat 10 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities
REPTED 16,679,2002
oral/rat 8250 mg/kg (14-21D preg/3D after birth)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Other developmental abnormalities
REPTED 16,679,2002
oral/rat 11.3 gm/kg (7-21D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemREPTED 18,53,2004
oral/rat 18000 mg/kg (15D preg-10D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTXAPA9 208,127,2005
oral/rat 3750 mg/kg (13-17D pregnant)Reproductive: Other developmental abnormalitiesREPTED 28,66,2009

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 201 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** OTS0556283-3

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 900 mg/kgKidney, Ureter, and Bladder: Other changesTOXID9 60,309,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 11256 mg/kg/28D- continuousLiver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 3,157,1983
oral/rat lowest published toxic dose: 109 gm/kg/13W- continuousKidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia

Related to Chronic Data: Changes in uterine weight
NTIS** OTS0530645
oral/rat lowest published toxic dose: 450 mg/kg/5D- intermittentKidney, Ureter, and Bladder: Other changesTOXID9 60,309,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWREPTED 16,679,2002
TOXICOLOGY REVIEWTXAPA9 197,178,2004
TOXICOLOGY REVIEWCRTXB2 36,695,2006

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 3 mg/m3, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 3 mg/m3, NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3, OCT2007

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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